Sulconazole nitrate


Entry
D00886                      Drug                                   
Name
Sulconazole nitrate (JAN/USP);
Exelderm (TN)
Product
SULCONAZOLE NITRATE (JG Pharma), SULCONAZOLE NITRATE (JG Pharma), EXELDERM (Journey Medical Corporation), EXELDERM (Journey Medical Corporation)
Formula
C18H15Cl3N2S. HNO3
Exact mass
458.9978
Mol weight
460.7619
Structure
Simcomp
Class
Antifungal
 DG01883  Imidazole antifungal
Remark
Therapeutic category: 2655
ATC code: D01AC09
Chemical structure group: DG00366
Product (DG00366): D00886<JP/US>
Efficacy
Antifungal, Ergosterol biosynthesis inhibitor
  Disease
Tinea pedis [DS:H01316]
Tinea versicolor [DS:H01334]
Comment
Imidazole derivative
Target
sterol 14alpha-demethylase [KO:K05917]
  Pathway
ko00100  Steroid biosynthesis
Interaction
Structure map
map07026  Antifungal agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AC Imidazole and triazole derivatives
     D01AC09 Sulconazole
      D00886  Sulconazole nitrate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Topical Anti-infectives
   Antifungals, dermatological
    Sulconazole
     D00886  Sulconazole nitrate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   265  Antiparasitic dermatosis agents
    2655  Imidazoles
     D00886  Sulconazole nitrate (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  58 Ringworm drugs
   D00886  Sulconazole nitrate (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Sulconazole
    D00886  Sulconazole nitrate (JAN/USP)
Drug groups [BR:br08330]
 Antifungal
  DG01883  Imidazole antifungal
   DG00366  Sulconazole
    D00886  Sulconazole nitrate
Drug classes [BR:br08332]
 Antifungal
  DG01883  Imidazole antifungal
   D00886  Sulconazole nitrate
Antimicrobials [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   Imidazole
    D00886  Sulconazole nitrate (JAN/USP) <JP/US>
Rx-to-OTC switch list in Japan [br08314.html]
 D00886
Drug groups [BR:br08330]
 Antifungal
  DG01883  Imidazole antifungal
   DG00366  Sulconazole
Other DBs
CAS: 61318-91-0
PubChem: 7847950
ChEBI: 9326
LigandBox: D00886
NIKKAJI: J364.821D
KCF data

ATOM        28
            1   N2b N    39.2735  -20.6975 #+
            2   O3a O    39.2676  -19.3000
            3   O3a O    40.4959  -21.3962 #-
            4   O1b O    38.0517  -21.4097
            5   C8y C    26.0400  -14.4900
            6   C8x C    26.0400  -15.8900
            7   C8x C    27.2524  -16.5900
            8   C8y C    28.4649  -15.8900
            9   C8x C    28.4649  -14.4900
            10  C8x C    27.2524  -13.7900
            11  X   Cl   24.8276  -13.7900
            12  C1b C    29.6960  -16.6010
            13  S2a S    30.9012  -15.9053
            14  C1c C    32.0835  -16.5881
            15  C1b C    33.2775  -15.8988
            16  C8y C    32.0835  -17.9898
            17  N4y N    34.4654  -16.5848
            18  C8x C    34.8840  -17.9125
            19  C8y C    30.8535  -18.7001
            20  C8x C    30.8536  -20.1001
            21  C8y C    32.0661  -20.8000
            22  C8x C    33.2961  -20.0897
            23  C8x C    33.2960  -18.6897
            24  N5x N    36.2839  -17.9244
            25  C8x C    36.7278  -16.5966
            26  C8x C    35.6023  -15.7642
            27  X   Cl   29.6491  -18.0048
            28  X   Cl   32.0662  -22.1900
BOND        29
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     5   6 2
            5     6   7 1
            6     7   8 2
            7     8   9 1
            8     9  10 2
            9     5  10 1
            10    5  11 1
            11    8  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   14  16 1
            16   15  17 1
            17   17  18 1
            18   16  19 2
            19   19  20 1
            20   20  21 2
            21   21  22 1
            22   22  23 2
            23   16  23 1
            24   18  24 2
            25   24  25 1
            26   25  26 2
            27   17  26 1
            28   19  27 1
            29   21  28 1