Cefazolin sodium


Entry
D00905                      Drug                                   
Name
Cefazolin sodium (JP18/USP);
Ancef (TN)
Product
CEFAZOLIN SODIUM (B. Braun Medical), CEFAZOLIN (Baxter Healthcare Corporation)
  Generic
CEFAZOLIN (A-S Medication Solutions), CEFAZOLIN (Apotex Corp.), CEFAZOLIN (Apotex Corp.), CEFAZOLIN (Apotex Corp.), CEFAZOLIN (Apotex Corp.), CEFAZOLIN (Civica), CEFAZOLIN (Civica), CEFAZOLIN (General Injectables & Vaccines), CEFAZOLIN (General Injectables & Vaccines), CEFAZOLIN (General Injectables and Vaccines), CEFAZOLIN (Henry Schein), CEFAZOLIN (Henry Schein), CEFAZOLIN (Henry Schein), CEFAZOLIN (Hikma Pharmaceuticals USA), CEFAZOLIN (Hikma Pharmaceuticals USA), CEFAZOLIN (Hospira), CEFAZOLIN (Medical Purchasing Solutions), CEFAZOLIN (Medical Purchasing Solutions), CEFAZOLIN (Proficient Rx LP), CEFAZOLIN (Qilu Pharmaceutical), CEFAZOLIN (REMEDYREPACK), CEFAZOLIN (Sandoz), CEFAZOLIN (Sandoz), CEFAZOLIN (WG Critical Care), CEFAZOLIN (WG Critical Care), CEFAZOLIN (WG Critical Care), CEFAZOLIN (West-Ward Pharmaceuticals Corp), CEFAZOLIN (West-Ward Pharmaceuticals Corp), CEFAZOLIN (Fresenius Kabi USA), CEFAZOLIN (Fresenius Kabi USA), CEFAZOLIN (Sagent Pharmaceuticals), CEFAZOLIN (Sagent Pharmaceuticals), CEFAZOLIN (Sagent Pharmaceuticals), CEFAZOLIN (Sagent Pharmaceuticals), CEFAZOLIN (Samson Medical Technologies)
Formula
C14H13N8O4S3. Na
Exact mass
476.012
Mol weight
476.489
Structure
Simcomp
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
 DG01774  First-generation cephalosporin
Remark
Same as: C08098
Therapeutic category: 6132
ATC code: J01DB04
Chemical structure group: DG00550
Product (DG00550): D00905<JP/US> D02226<JP>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
  Disease
Bacterial endocarditis [DS:H00334]
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Structure map
map07012  Cephalosporins - parenteral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DB First-generation cephalosporins
     J01DB04 Cefazolin
      D00905  Cefazolin sodium (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Cephalosporins
   Cefazolin
    D00905  Cefazolin sodium (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D00905  Cefazolin sodium (JP18/USP)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00550  Cefazolin
      D00905  Cefazolin sodium
  DG01774  First-generation cephalosporin
   DG00550  Cefazolin
    D00905  Cefazolin sodium
Drug classes [BR:br08332]
 Antibacterial
  DG01488  Cephem
   D00905  Cefazolin sodium
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   First-generation cephalosporin
    D00905  Cefazolin sodium (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00905  Cefazolin sodium
  D00905  Cefazolin sodium for injection
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00550  Cefazolin
  DG01774  First-generation cephalosporin
   DG00550  Cefazolin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   First-generation cephalosporin
    DG00550  Cefazolin
Other DBs
CAS: 27164-46-1
PubChem: 7847969
ChEBI: 3483
LigandBox: D00905
NIKKAJI: J9.885J
KCF data

ATOM        30
            1   C1y C    18.0487  -14.7849
            2   N1y N    18.0487  -16.1806
            3   C2y C    19.2576  -16.8783
            4   C2y C    20.4663  -16.1806
            5   C1x C    20.4663  -14.7849
            6   S2x S    19.2576  -14.0870
            7   C1y C    16.6529  -14.7849
            8   C5x C    16.6529  -16.1806
            9   N1b N    15.4443  -14.0870
            10  C5a C    14.2354  -14.7849
            11  O5a O    14.2354  -16.1806
            12  O5x O    15.4443  -16.8783
            13  C1b C    13.0266  -14.0870
            14  C1b C    21.6935  -16.8895
            15  C6a C    19.2576  -18.2739
            16  O6a O    18.0319  -18.9816
            17  O6a O    20.4493  -18.9621 #-
            18  N4y N    11.7985  -14.7965
            19  S2a S    22.9071  -16.1890
            20  C8y C    24.1155  -16.8870
            21  N5x N    24.5393  -18.2151
            22  N5x N    25.9360  -18.2265
            23  C8y C    26.3784  -16.9017
            24  S2x S    25.2552  -16.0715
            25  C1a C    27.7744  -16.8829
            26  C8x C    10.6469  -13.9856
            27  N5x N     9.5153  -14.8305
            28  N5x N     9.9690  -16.1679
            29  N5x N    11.3811  -16.1498
            30  Z   Na   21.9094  -18.8997 #+
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16    3  15 1
            17   15  16 2
            18   15  17 1
            19   13  18 1
            20   14  19 1
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   23  24 1
            26   20  24 1
            27   23  25 1
            28   18  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   18  29 1