Entry

D00939                      Drug

Name

Alendronate sodium (USP);
Alendronate sodium hydrate (JP18);
Binosto (TN);
Fosamax (TN)

Product

BINOSTO (ASCEND Therapeutics U.S.), FOSAMAX (Organon LLC)

Generic

ALENDRONATE SODIUM (A-S Medication Solutions), ALENDRONATE SODIUM (A-S Medication Solutions), ALENDRONATE SODIUM (A-S Medication Solutions), ALENDRONATE (A-S Medication Solutions), ALENDRONATE SODIUM (A-S Medication Solutions), ALENDRONATE SODIUM (A-S Medication Solutions), ALENDRONATE SODIUM (A-S Medication Solutions), ALENDRONATE SODIUM (Amneal Pharmaceuticals of New York LLC), ALENDRONATE SODIUM (Aurobindo Pharma Limited), ALENDRONATE (Bryant Ranch Prepack), ALENDRONATE SODIUM (Cipla USA), ALENDRONATE SODIUM (DIRECT RX), ALENDRONATE SODIUM (Direct_Rx), ALENDRONATE SODIUM (Golden State Medical Supply), ALENDRONATE (Hangzhou Minsheng Binjiang Pharmaceutical), ALENDRONATE SODIUM (Hikma Pharmaceuticals USA), ALENDRONATE SODIUM (NorthStar Rx LLC), ALENDRONATE SODIUM (NuCare Pharmaceuticals), ALENDRONATE SODIUM (NuCare Pharmaceuticals), ALENDRONATE (NuCare Pharmaceuticals), ALENDRONATE SODIUM (NuCare Pharmaceuticals), ALENDRONATE SODIUM (Preferred Pharmaceuticals), ALENDRONATE SODIUM (Preferred Pharmaceuticals), ALENDRONATE SODIUM (Proficient Rx LP), ALENDRONATE SODIUM (REMEDYREPACK), ALENDRONATE SODIUM (Rising Pharmaceuticals), ALENDRONATE (Virtus Pharmaceuticals), ALENDRONATE (Marlex Pharmaceuticals)

Formula

C4H12NO7P2. 3H2O. Na

Exact mass

325.0304

Mol weight

325.1237

Structure

Simcomp

Class

Musculo-skeletal system agent
DG03232 Osteoporosis agent
DG01600 Bisphosphonate

Remark

Therapeutic category:

3999

ATC code:

M05BA04

Chemical structure group:

DG00783

Product (DG00783):

D00939<JP/US>

Product (mixture):

D10841<US>

Efficacy

Antiresorptive, Osteoporosis agent, Farnesylpyrophosphate synthetase inhibitor

Disease

Osteoporosis [DS:H01593]
Glucocorticoid-induced osteoporosis [DS:H01709]
Paget's disease of bone [DS:H00437]

Comment

Bisphosphonate

Target

FDPS [HSA:2224] [KO:K00787]

Pathway

hsa00900

Terpenoid backbone biosynthesis

Interaction

Structure map

map07047

Osteoporosis drugs

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
  M05 DRUGS FOR TREATMENT OF BONE DISEASES
   M05B DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
    M05BA Bisphosphonates
     M05BA04 Alendronic acid
      D00939  Alendronate sodium (USP) <JP/US>
USP drug classification [BR:br08302]
Metabolic Bone Disease Agents
  Bisphosphonates
   Alendronate
    D00939  Alendronate sodium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D00939  Alendronate sodium (USP); Alendronate sodium hydrate (JP18)
Drug groups [BR:br08330]
Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   DG01600  Bisphosphonate
    DG00783  Alendronic acid
     D00939  Alendronate sodium
Drug classes [BR:br08332]
Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   D00939  Alendronate sodium
Target-based classification of drugs [BR:br08310]
Enzymes
  Transferases (EC2)
   Alkyl/Aryl transferases
    FDPS
     D00939  Alendronate sodium (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00939  Alendronate sodium hydrate
  D00939  Alendronate sodium tablets
  D00939  Alendronate sodium injection
Drug groups [BR:br08330]
Musculo-skeletal system agent
  DG03232  Osteoporosis agent
   DG01600  Bisphosphonate
    DG00783  Alendronic acid

Other DBs

CAS:	121268-17-5

PubChem:

7848002

ChEBI:

2566

LigandBox:

D00939

NIKKAJI:

J1.639.609E J2.222.290B

KCF data

ATOM        18
            1   O0  O    29.9425  -25.6767
            2   Z   Na   26.3872  -22.7066 #+
            3   P1b P    22.2600  -24.5000
            4   C1d C    23.5900  -24.5000
            5   C1b C    23.5900  -22.6100
            6   O1a O    23.5900  -25.8300
            7   P1b P    24.9900  -24.5000
            8   O1c O    26.3200  -24.5000 #-
            9   O1c O    20.8600  -24.5000
            10  O1c O    22.2600  -23.1000
            11  O1c O    24.9900  -23.1000
            12  C1b C    24.7800  -21.9800
            13  C1b C    24.7800  -20.5800
            14  N1a N    25.9700  -19.8800
            15  O1c O    22.2600  -25.8300
            16  O1c O    24.9900  -25.8300
            17  O0  O    29.9425  -25.6767
            18  O0  O    29.9425  -25.6767
BOND        13
            1     3   4 1
            2     4   5 1
            3     4   6 1
            4     4   7 1
            5     7   8 1
            6     3   9 1
            7     3  10 2
            8     7  11 2
            9     5  12 1
            10   12  13 1
            11   13  14 1
            12    3  15 1
            13    7  16 1
BRACKET     1    28.2800  -26.7400   28.2800  -24.7800
            1    30.3100  -24.7800   30.3100  -26.7400
            1  3
ORIGINAL  1    1
REPEAT    1   17  18