Entry

D00945                      Drug

Name

Pioglitazone hydrochloride (JP18/USP);
Actos (TN)

Product

ACTOS (Takeda Pharmaceuticals America)

Generic

PIOGLITAZONE (A-S Medication Solutions), PIOGLITAZONE HYDROCHLORIDE (A-S Medication Solutions), PIOGLITAZONE (A-S Medication Solutions), PIOGLITAZONE (A-S Medication Solutions), PIOGLITAZONE (A-S Medication Solutions), PIOGLITAZONE (A-S Medication Solutions), PIOGLITAZONE (Accord Healthcare), PIOGLITAZONE (American Health Packaging), PIOGLITAZONE (Aphena Pharma Solutions - Tennessee), PIOGLITAZONE (Bryant Ranch Prepack), PIOGLITAZONE (Bryant Ranch Prepack), PIOGLITAZONE (Bryant Ranch Prepack), PIOGLITAZONE (Bryant Ranch Prepack), PIOGLITAZONE (Bryant Ranch Prepack), PIOGLITAZONE (Bryant Ranch Prepack), PIOGLITAZONE (Bryant Ranch Prepack), PIOGLITAZONE (Bryant Ranch Prepack), PIOGLITAZONE (Cadila Healthcare Limited), PIOGLITAZONE (DIRECT RX), PIOGLITAZONE (Denton Pharma), PIOGLITAZONE (DirectRX), PIOGLITAZONE (DirectRX), PIOGLITAZONE (Direct_Rx), PIOGLITAZONE (Macleods Pharmaceuticals Limited), PIOGLITAZONE (Major Pharmaceuticals), PIOGLITAZONE (NorthStar RxLLC), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (NuCare Pharmaceuticals), PIOGLITAZONE (Preferred Pharmaceuticals), PIOGLITAZONE (Preferred Pharmaceuticals), PIOGLITAZONE (Preferred Pharmaceuticals), PIOGLITAZONE (REMEDYREPACK), PIOGLITAZONE (REMEDYREPACK), PIOGLITAZONE (REMEDYREPACK), PIOGLITAZONE (RPK Pharmaceuticals), PIOGLITAZONE (RPK Pharmaceuticals), PIOGLITAZONE (RPK Pharmaceuticals), PIOGLITAZONE (Rising Health), PIOGLITAZONE (Sandoz), PIOGLITAZONE (Solco Healthcare LLC), PIOGLITAZONE (Teva Pharmaceuticals USA), PIOGLITAZONE (Zydus Pharmaceuticals (USA)), PIOGLITAZONE HYDROCHLORIDE (A-S Medication Solutions), PIOGLITAZONE HYDROCHLORIDE (ACETRIS HEALTH), PIOGLITAZONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PIOGLITAZONE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), PIOGLITAZONE HYDROCHLORIDE (Aurobindo Pharma Limited), PIOGLITAZONE HYDROCHLORIDE (Bryant Ranch Prepack), PIOGLITAZONE HYDROCHLORIDE (Bryant Ranch Prepack), PIOGLITAZONE HYDROCHLORIDE (Bryant Ranch Prepack), PIOGLITAZONE HYDROCHLORIDE (Bryant Ranch Prepack), PIOGLITAZONE HYDROCHLORIDE (CELLTRION USA), PIOGLITAZONE HYDROCHLORIDE (CELLTRION USA), PIOGLITAZONE HYDROCHLORIDE (DirectRx), PIOGLITAZONE HYDROCHLORIDE (NuCare Pharmaceuticals), PIOGLITAZONE HYDROCHLORIDE (NuCare Pharmaceuticals), PIOGLITAZONE HYDROCHLORIDE (NuCare Pharmaceuticals), PIOGLITAZONE HYDROCHLORIDE (NuCare Pharmaceuticals), PIOGLITAZONE HYDROCHLORIDE (Preferred Pharmaceuticals), PIOGLITAZONE HYDROCHLORIDE (Preferred Pharmaceuticals), PIOGLITAZONEHYDROCHLORIDE (NuCare Pharmaceuticals), PIOGLITAZONEHYDROCHLORIDE (NuCare Pharmaceuticals), PIOGLITAZONEHYDROCHLORIDE (Proficient Rx LP), PIOGLITAZONEHYDROCHLORIDE (RPK Pharmaceuticals), PIOGLITAZONEHYDROCHLORIDE (RPK Pharmaceuticals)

Formula

C19H20N2O3S. HCl

Exact mass

392.0961

Mol weight

392.8996

Structure

Simcomp

Class

Antidiabetic agent
DG01685  Insulin sensitizer
  DG01795  PPAR gamma agonist
   DG01683  Thiazolidinedione
DG02044  Hypoglycemic agent
  DG01683  Thiazolidinedione
Metabolizing enzyme substrate
DG02918  CYP2C8 substrate

Remark

Therapeutic category:

3969

ATC code:

A10BG03

Chemical structure group:

DG00117

Product (DG00117):

D00945<JP/US>

Product (mixture):

D09744<JP/US> D09848<JP/US> D10159<JP/US>

Efficacy

Antidiabetic, Peroxisome proliferator-activated receptor (PPAR) gamma agonist

Disease

Type 2 diabetes mellitus [DS:H00409]

Comment

Thiazolidinedione derivative

Target

NR1C3 (PPARG) [HSA:5468] [KO:K08530]

Pathway

hsa03320

PPAR signaling pathway

hsa04152

AMPK signaling pathway

Metabolism

Enzyme: CYP2C8 [HSA:1558]

Interaction

Structure map

map07051

Antidiabetics

map07222

Peroxisome proliferator-activated receptor (PPAR) agonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BG Thiazolidinediones
     A10BG03 Pioglitazone
      D00945  Pioglitazone hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Blood Glucose Regulators
  Antidiabetic Agents
   Thiazolidinedione
    Pioglitazone
     D00945  Pioglitazone hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D00945  Pioglitazone hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Antidiabetic agent
  DG01685  Insulin sensitizer
   DG01795  PPAR gamma agonist
    DG01683  Thiazolidinedione
     DG00117  Pioglitazone
      D00945  Pioglitazone hydrochloride
  DG02044  Hypoglycemic agent
   DG01683  Thiazolidinedione
    DG00117  Pioglitazone
     D00945  Pioglitazone hydrochloride
Metabolizing enzyme substrate
  DG02918  CYP2C8 substrate
   DG00117  Pioglitazone
    D00945  Pioglitazone hydrochloride
Drug classes [BR:br08332]
Antidiabetic agent
  DG01683  Thiazolidinedione
   D00945  Pioglitazone hydrochloride
  DG02044  Hypoglycemic agent
   D00945  Pioglitazone hydrochloride
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    NR1C3 (PPARG)
     D00945  Pioglitazone hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00945  Pioglitazone hydrochloride
  D00945  Pioglitazone hydrochloride tablets
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D00945
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D00945
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D00945
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00945
Drug groups [BR:br08330]
Antidiabetic agent
  DG01685  Insulin sensitizer
   DG01795  PPAR gamma agonist
    DG01683  Thiazolidinedione
     DG00117  Pioglitazone
  DG02044  Hypoglycemic agent
   DG01683  Thiazolidinedione
    DG00117  Pioglitazone
Metabolizing enzyme substrate
  DG02918  CYP2C8 substrate
   DG00117  Pioglitazone

Other DBs

CAS:	112529-15-4

PubChem:

7848008

ChEBI:

8229

LigandBox:

D00945

NIKKAJI:

J1.892.976G

KCF data

ATOM        26
            1   C1y C    36.4918  -16.3605
            2   C1b C    35.2747  -15.6584
            3   C5x C    36.5002  -17.7636
            4   S2x S    37.8328  -15.9323
            5   C8y C    34.0636  -16.3605
            6   N1x N    37.8315  -18.1968
            7   O5x O    35.3724  -18.5929
            8   C5x C    38.6556  -17.0654
            9   C8x C    32.8527  -15.6584
            10  C8x C    34.0636  -17.7589
            11  O5x O    40.0558  -17.0643
            12  C8x C    31.6415  -16.3605
            13  C8x C    32.8527  -18.4610
            14  C8y C    31.6415  -17.7589
            15  O2a O    30.4304  -18.4610
            16  C1b C    29.2134  -17.7589
            17  C1b C    28.0023  -18.4610
            18  C8y C    26.7911  -17.7589
            19  C8x C    26.7911  -16.3664
            20  N5x N    25.5800  -18.4668
            21  C8x C    25.5800  -15.6701
            22  C8x C    24.3689  -17.7647
            23  C8y C    24.3689  -16.3664
            24  C1b C    23.1580  -15.6701
            25  C1a C    21.9409  -16.3664
            26  X   Cl   42.2119  -18.3454
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 2
            9     5  10 1
            10    8  11 2
            11    9  12 1
            12   10  13 2
            13   12  14 2
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 2
            19   18  20 1
            20   19  21 1
            21   20  22 2
            22   21  23 2
            23   23  24 1
            24   24  25 1
            25    6   8 1
            26   13  14 1
            27   22  23 1