Entry

D00951                      Drug

Name

Medroxyprogesterone acetate (JP18/USP);
Depo-provera (TN);
Depo-subq provera 104 (TN);
Provera (TN)

Product

DEPO-PROVERA (Pharmacia & Upjohn Company LLC), DEPO-SUBQ PROVERA (Pharmacia & Upjohn Company LLC), PROVERA (Pharmacia and Upjohn Company)

Generic

MEDROXYPROGESTERONE (PharmPak), MEDROXYPROGESTERONE ACETATE (A-S Medication Solutions), MEDROXYPROGESTERONE ACETATE (A-S Medication Solutions), MEDROXYPROGESTERONE ACETATE (A-S Medication Solutions), MEDROXYPROGESTERONE ACETATE (A-S Medication Solutions), MEDROXYPROGESTERONE ACETATE (A-S Medication Solutions), MEDROXYPROGESTERONE ACETATE (A-S Medication Solutions), MEDROXYPROGESTERONE ACETATE (A-S Medication Solutions), MEDROXYPROGESTERONE ACETATE (A-S Medication Solutions), MEDROXYPROGESTERONE ACETATE (Afaxys Pharma), MEDROXYPROGESTERONE ACETATE (American Health Packaging), MEDROXYPROGESTERONE ACETATE (Amphastar Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (Amphastar Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (AuroMedics Pharma LLC), MEDROXYPROGESTERONE ACETATE (Bryant Ranch Prepack), MEDROXYPROGESTERONE ACETATE (Bryant Ranch Prepack), MEDROXYPROGESTERONE ACETATE (Bryant Ranch Prepack), MEDROXYPROGESTERONE ACETATE (Bryant Ranch Prepack), MEDROXYPROGESTERONE ACETATE (Bryant Ranch Prepack), MEDROXYPROGESTERONE ACETATE (Bryant Ranch Prepack), MEDROXYPROGESTERONE ACETATE (Cipla USA), MEDROXYPROGESTERONE ACETATE (Greenstone LLC), MEDROXYPROGESTERONE ACETATE (Greenstone LLC), MEDROXYPROGESTERONE ACETATE (Mylan Institutional LLC), MEDROXYPROGESTERONE ACETATE (NorthStar RxLLC), MEDROXYPROGESTERONE ACETATE (NorthStar RxLLC), MEDROXYPROGESTERONE ACETATE (Northstar RxLLC), MEDROXYPROGESTERONE ACETATE (NuCare Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (NuCare Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (NuCare Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (PD-Rx Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (PD-Rx Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (Prasco Laboratories), MEDROXYPROGESTERONE ACETATE (Preferred Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (Preferred Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (Proficient Rx LP), MEDROXYPROGESTERONE ACETATE (Proficient Rx LP), MEDROXYPROGESTERONE ACETATE (REMEDYREPACK), MEDROXYPROGESTERONE ACETATE (REMEDYREPACK), MEDROXYPROGESTERONE ACETATE (RPK Pharmaceuticals), MEDROXYPROGESTERONE ACETATE (RedPharm Drug), MEDROXYPROGESTERONE ACETATE (Sun Pharmaceutical Industries), MEDROXYPROGESTERONE ACETATE (Sun Pharmaceutical Industries), MEDROXYPROGESTERONE ACETATE (Teva Parenteral Medicines), MEDROXYPROGESTERONE ACETATE (Teva Pharmaceuticals USA)

Formula

C24H34O4

Exact mass

386.2457

Mol weight

386.5244

Structure

Simcomp

Class

Hormonal agent
DG02004 Progesterone
DG01666 Progesterone receptor agonist

Remark

Same as:

C08150

Therapeutic category:

2478

ATC code:

G03AC06 G03DA02 L02AB02

Chemical structure group:

DG00458

Product (DG00458):

D00951<JP/US>

Efficacy

Antineoplastic, Contraceptive, Progesterone receptor agonist

Disease

Endometriosis [DS:H01639]
Endometrial carcinoma [DS:H00026]
Renal carcinoma [DS:H00021]

Comment

Progestin

Target

NR3C3 (PGR) [HSA:5241] [KO:K08556]

Pathway

hsa04114

Oocyte meiosis

hsa04914

Progesterone-mediated oocyte maturation

hsa04915

Estrogen signaling pathway

hsa05224

Breast cancer

Interaction

Structure map

map07043

Antineoplastics - hormones

map07226

Progesterone, androgen and estrogen receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC06 Medroxyprogesterone
      D00951  Medroxyprogesterone acetate (JP18/USP) <JP/US>
   G03D PROGESTOGENS
    G03DA Pregnen (4) derivatives
     G03DA02 Medroxyprogesterone
      D00951  Medroxyprogesterone acetate (JP18/USP) <JP/US>
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02A HORMONES AND RELATED AGENTS
    L02AB Progestogens
     L02AB02 Medroxyprogesterone
      D00951  Medroxyprogesterone acetate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Contraceptives
  Contraceptives, Other
   Medroxyprogesterone
    D00951  Medroxyprogesterone acetate (JP18/USP)
Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Medroxyprogesterone
    D00951  Medroxyprogesterone acetate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2478  Synthetic progestins
     D00951  Medroxyprogesterone acetate (JP18/USP)
Drug groups [BR:br08330]
Hormonal agent
  DG02004  Progesterone
   DG00458  Medroxyprogesterone
    D00951  Medroxyprogesterone acetate
  DG01666  Progesterone receptor agonist
   DG00458  Medroxyprogesterone
    D00951  Medroxyprogesterone acetate
Drug classes [BR:br08332]
Endocrine and hormonal agent
  DG02004  Progesterone
   D00951  Medroxyprogesterone acetate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D00951  Medroxyprogesterone acetate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00951  Medroxyprogesterone acetate
Drug groups [BR:br08330]
Hormonal agent
  DG02004  Progesterone
   DG00458  Medroxyprogesterone
  DG01666  Progesterone receptor agonist
   DG00458  Medroxyprogesterone

Other DBs

CAS:

71-58-9

PubChem:

7848014

ChEBI:

6716

LigandBox:

D00951

NIKKAJI:

J5.247G

KCF data

ATOM        28
            1   C1z C    28.1133  -17.0474
            2   C1z C    26.9252  -17.7172
            3   C1x C    29.2900  -17.7348
            4   O7a O    29.2900  -16.3485
            5   C5a C    28.1718  -15.6728
            6   C1y C    26.9192  -19.0861
            7   C1x C    25.7544  -17.0299
            8   C1a C    26.9778  -16.3485
            9   C1x C    29.2843  -19.0978
            10  C7a C    30.4782  -17.0299
            11  C1a C    26.9019  -14.9796
            12  O5a O    29.3543  -14.9738
            13  C1y C    25.7311  -19.7675
            14  C1x C    24.5603  -17.6998
            15  C1a C    31.6606  -16.3426
            16  O6a O    30.4724  -18.4045
            17  C1y C    24.5487  -19.0685
            18  C1x C    25.7311  -21.1364
            19  C1z C    23.3603  -19.7559
            20  C1y C    24.5370  -21.8238
            21  C2y C    23.3546  -21.1248
            22  C1x C    22.1781  -19.0628
            23  C1a C    23.3488  -18.3812
            24  C1a C    24.5953  -23.1868
            25  C2x C    22.1781  -21.8178
            26  C1x C    20.9840  -19.7559
            27  C5x C    20.9840  -21.1248
            28  O5x O    19.7957  -21.8062
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    5  12 2
            12    6  13 1
            13    7  14 1
            14   10  15 1
            15   10  16 2
            16   13  17 1
            17   13  18 1
            18   17  19 1
            19   18  20 1
            20   19  21 1
            21   19  22 1
            22   19  23 1 #Up
            23   20  24 1 #Down
            24   21  25 2
            25   22  26 1
            26   25  27 1
            27   27  28 2
            28    6   9 1
            29   14  17 1
            30   20  21 1
            31   26  27 1