Megestrol acetate


Entry
D00952                      Drug                                   
Name
Megestrol acetate (USP);
Megace (TN)
Product
  Generic
MEGESTROL ACETATE (ATLANTIC BIOLOGICALS CORP.), MEGESTROL ACETATE (ATLANTIC BIOLOGICALS CORP.), MEGESTROL ACETATE (Akorn), MEGESTROL ACETATE (Bryant Ranch Prepack), MEGESTROL ACETATE (Bryant Ranch Prepack), MEGESTROL ACETATE (Cardinal Health), MEGESTROL ACETATE (Golden State Medical Supply), MEGESTROL ACETATE (Major Pharmaceuticals), MEGESTROL ACETATE (Major Pharmaceuticals), MEGESTROL ACETATE (Major Pharmaceuticals), MEGESTROL ACETATE (McKesson Corporation DBA SKY Packaging), MEGESTROL ACETATE (Morton Grove Pharmaceuticals), MEGESTROL ACETATE (PINNACLE PHARMA LLC), MEGESTROL ACETATE (Par Pharmaceutical), MEGESTROL ACETATE (Par Pharmaceutical), MEGESTROL ACETATE (Par Pharmaceutical), MEGESTROL ACETATE (Pharmaceutical Associates), MEGESTROL ACETATE (Pharmaceutical Associates), MEGESTROL ACETATE (Precision Dose), MEGESTROL ACETATE (Precision Dose), MEGESTROL ACETATE (Precision Dose), MEGESTROL ACETATE (Precision Dose), MEGESTROL ACETATE (Proficient Rx LP), MEGESTROL ACETATE (Strides Pharma Science Limited), MEGESTROL ACETATE (Strides Pharma Science Limited), MEGESTROL ACETATE (TWi Pharmaceuticals), MEGESTROL ACETATE (Teva Pharmaceuticals USA), MEGESTROL ACETATE (VistaPharm)
Formula
C24H32O4
Exact mass
384.2301
Mol weight
384.5085
Structure
Simcomp
Class
Hormonal agent
 DG02004  Progesterone
 DG01666  Progesterone receptor agonist
Remark
Same as: C08151
ATC code: G03AC05 G03DB02 L02AB01
Chemical structure group: DG00457
Product (DG00457): D00952<US>
Efficacy
Antineoplastic, Contraceptive, Progesterone receptor agonist
Comment
Progestin
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Interaction
Structure map
map07043  Antineoplastics - hormones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC05 Megestrol
      D00952  Megestrol acetate (USP) <US>
   G03D PROGESTOGENS
    G03DB Pregnadien derivatives
     G03DB02 Megestrol
      D00952  Megestrol acetate (USP) <US>
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02A HORMONES AND RELATED AGENTS
    L02AB Progestogens
     L02AB01 Megestrol
      D00952  Megestrol acetate (USP) <US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Megestrol
    D00952  Megestrol acetate (USP)
Drug groups [BR:br08330]
 Hormonal agent
  DG02004  Progesterone
   DG00457  Megestrol
    D00952  Megestrol acetate
  DG01666  Progesterone receptor agonist
   DG00457  Megestrol
    D00952  Megestrol acetate
Drug classes [BR:br08332]
 Endocrine and hormonal agent
  DG02004  Progesterone
   D00952  Megestrol acetate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D00952  Megestrol acetate (USP) <US>
Drug groups [BR:br08330]
 Hormonal agent
  DG02004  Progesterone
   DG00457  Megestrol
  DG01666  Progesterone receptor agonist
   DG00457  Megestrol
Other DBs
CAS: 595-33-5
PubChem: 7848015
ChEBI: 6723
LigandBox: D00952
NIKKAJI: J6.777F
KCF data

ATOM        28
            1   C1z C    28.1137  -17.0472
            2   C1z C    26.9253  -17.7170
            3   C1x C    29.2906  -17.7287
            4   O7a O    29.2906  -16.3538
            5   C5a C    28.1722  -15.6723
            6   C1y C    26.9837  -19.0862
            7   C1x C    25.7544  -17.0296
            8   C1a C    26.9079  -16.3481
            9   C1x C    29.2789  -19.0978
            10  C7a C    30.4789  -17.0355
            11  C1a C    26.9020  -14.9789
            12  O5a O    29.2848  -14.9732
            13  C1y C    25.7311  -19.7677
            14  C1x C    24.5601  -17.6996
            15  C1a C    31.6616  -16.3481
            16  O6a O    30.4732  -18.4104
            17  C1y C    24.5484  -19.0686
            18  C2x C    25.7311  -21.1368
            19  C1z C    23.3599  -19.7503
            20  C2y C    24.5368  -21.8184
            21  C2y C    23.3542  -21.1252
            22  C1x C    22.1774  -19.0629
            23  C1a C    23.3484  -18.3812
            24  C1a C    24.5951  -23.1875
            25  C2x C    22.1774  -21.8184
            26  C1x C    20.9832  -19.7503
            27  C5x C    20.9832  -21.1252
            28  O5x O    19.7946  -21.8067
BOND        31
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     2   8 1 #Up
            8     3   9 1
            9     4  10 1
            10    5  11 1
            11    5  12 2
            12    6  13 1
            13    7  14 1
            14   10  15 1
            15   10  16 2
            16   13  17 1
            17   13  18 1
            18   17  19 1
            19   18  20 2
            20   19  21 1
            21   19  22 1
            22   19  23 1 #Up
            23   20  24 1
            24   21  25 2
            25   22  26 1
            26   25  27 1
            27   27  28 2
            28    6   9 1
            29   14  17 1
            30   20  21 1
            31   26  27 1