Norethindrone acetate


Entry
D00953                      Drug                                   
Name
Norethindrone acetate (USP);
Norethisterone acetate (JAN);
Aygestin (TN)
Product
  Generic
NORETHINDRONE ACETATE (Amneal Pharmaceuticals LLC), NORETHINDRONE ACETATE (AvKARE), NORETHINDRONE ACETATE (Glenmark Pharmaceuticals), NORETHINDRONE ACETATE (Ingenus Pharmaceuticals), NORETHINDRONE ACETATE (Mylan Pharmaceuticals), NORETHINDRONE ACETATE (Rising Pharmaceuticals), NORETHINDRONE ACETATE (Teva Pharmaceuticals USA), AYGESTIN (Teva Women's Health)
Formula
C22H28O3
Exact mass
340.2038
Mol weight
340.4559
Structure
Simcomp
Class
Hormonal agent
 DG02004  Progesterone
 DG01666  Progesterone receptor agonist
Remark
Same as: C08152
ATC code: G03AC01 G03DC02
Chemical structure group: DG00456
Product (DG00456): D00182<JP/US> D00953<US>
Product (mixture): D04483<JP/US> D09188<JP/US> D12137<US> D12226<US>
Efficacy
Contraceptive, Progesterone receptor agonist
Comment
Progestin
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Interaction
Structure map
map07226  Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03A HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE
    G03AC Progestogens
     G03AC01 Norethisterone
      D00953  Norethindrone acetate (USP) <US>
   G03D PROGESTOGENS
    G03DC Estren derivatives
     G03DC02 Norethisterone
      D00953  Norethindrone acetate (USP) <US>
USP drug classification [BR:br08302]
 Contraceptives
  Oral Progestins
   Norethindrone
    D00953  Norethindrone acetate (USP)
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Norethindrone
    D00953  Norethindrone acetate (USP)
Drug groups [BR:br08330]
 Hormonal agent
  DG02004  Progesterone
   DG00456  Norethisterone
    D00953  Norethindrone acetate
  DG01666  Progesterone receptor agonist
   DG00456  Norethisterone
    D00953  Norethindrone acetate
Drug classes [BR:br08332]
 Endocrine and hormonal agent
  DG02004  Progesterone
   D00953  Norethindrone acetate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D00953  Norethindrone acetate (USP) <US>
Drug groups [BR:br08330]
 Hormonal agent
  DG02004  Progesterone
   DG00456  Norethisterone
  DG01666  Progesterone receptor agonist
   DG00456  Norethisterone
Other DBs
CAS: 51-98-9
PubChem: 7848016
ChEBI: 7628
LigandBox: D00953
NIKKAJI: J1.910K
KCF data

ATOM        25
            1   C1z C    26.8820  -17.0674
            2   C1z C    28.0682  -16.3895
            3   C1y C    26.8705  -18.4405
            4   C1x C    25.7075  -16.3836
            5   C1a C    26.8762  -15.7000
            6   C1x C    29.2545  -17.0791
            7   O7a O    28.0567  -15.0162
            8   C3b C    29.2487  -15.7000
            9   C1y C    25.6842  -19.1184
            10  C1x C    29.2429  -18.3822
            11  C1x C    24.5155  -17.0557
            12  C7a C    28.0567  -13.6548
            13  C3a C    30.4292  -15.0105
            14  C1y C    24.5038  -18.4231
            15  C1x C    25.6842  -20.4917
            16  C1a C    29.2429  -12.9710
            17  O6a O    26.8762  -12.9769
            18  C1y C    23.3175  -19.1009
            19  C1x C    24.4921  -21.1696
            20  C2y C    23.3118  -20.4800
            21  C1x C    22.1371  -18.4172
            22  C2x C    22.1371  -21.1636
            23  C1x C    20.9508  -19.1009
            24  C5x C    20.9508  -20.4800
            25  O5x O    19.7588  -21.1579
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1 #Up
            7     2   8 1 #Down
            8     3   9 1
            9     3  10 1
            10    4  11 1
            11    7  12 1
            12    8  13 3
            13    9  14 1
            14    9  15 1
            15   12  16 1
            16   12  17 2
            17   14  18 1
            18   15  19 1
            19   18  20 1
            20   18  21 1
            21   20  22 2
            22   21  23 1
            23   22  24 1
            24   24  25 2
            25    6  10 1
            26   11  14 1
            27   19  20 1
            28   23  24 1