Anastrozole

Entry

D00960                      Drug

Name

Anastrozole (JAN/USP/INN);
Arimidex (TN)

Product

ARIMIDEX (ANI Pharmaceuticals)

Generic

ANASTROZOLE (A-S Medication Solutions), ANASTROZOLE (A-S Medication Solutions), ANASTROZOLE (A-S Medication Solutions), ANASTROZOLE (Accord Healthcare), ANASTROZOLE (American Health Packaging), ANASTROZOLE (Asclemed USA), ANASTROZOLE (Aurobindo Pharma Limited), ANASTROZOLE (AvKARE), ANASTROZOLE (AvPAK), ANASTROZOLE (BluePoint Laboratories), ANASTROZOLE (Breckenridge Pharmaceutical), ANASTROZOLE (Bryant Ranch Prepack), ANASTROZOLE (Bryant Ranch Prepack), ANASTROZOLE (Chartwell RX), ANASTROZOLE (Denton Pharma), ANASTROZOLE (Lannett Company), ANASTROZOLE (Major Pharmaceuticals), ANASTROZOLE (Natco Pharma Limited), ANASTROZOLE (NuCare Pharmaceuticals), ANASTROZOLE (NuCare Pharmaceuticals), ANASTROZOLE (NuCare Pharmaceuticals), ANASTROZOLE (PD-Rx Pharmaceuticals), ANASTROZOLE (PD-Rx Pharmaceuticals), ANASTROZOLE (Proficient Rx LP), ANASTROZOLE (REMEDYREPACK), ANASTROZOLE (REMEDYREPACK), ANASTROZOLE (Rising Pharmaceuticals), ANASTROZOLE (Teva Pharmaceuticals USA), ANASTROZOLE (Zydus Lifesciences Limited), ANASTROZOLE (Zydus Pharmaceuticals (USA)), ANASTROZOLE (Yiling Pharmaceutical)

Formula

C17H19N5

Exact mass

293.164

Mol weight

293.3663

Structure

Simcomp

Class

Antineoplastic
DG01596  Aromatase inhibitor
DG01524  Triazole antineoplastic
Metabolizing enzyme inhibitor
DG01634  CYP1A2 inhibitor
DG01643  CYP2C9 inhibitor
DG02852  CYP3A/CYP3A4 inhibitor
  DG01522  CYP3A4 inhibitor

Remark

Same as:

C08159

Therapeutic category:

4291

ATC code:

L02BG03

Product:

D00960<JP/US>

Efficacy

Antineoplastic, Estrogen biosynthesis inhibitor

Disease

Breast cancer, postmenopausal (HR-positive or HR-unknown) [DS:H00031]

Comment

Aromatase inhibitor

Target

CYP19A1 (ARO) [HSA:1588] [KO:K07434]

Pathway

hsa00140

Steroid hormone biosynthesis

Interaction

CYP inhibition: CYP1A2 [HSA:1544], CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]

Structure map

map07043

Antineoplastics - hormones

Other map

map01522

Endocrine resistance

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02B HORMONE ANTAGONISTS AND RELATED AGENTS
    L02BG Aromatase inhibitors
     L02BG03 Anastrozole
      D00960  Anastrozole (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
  Aromatase Inhibitors, 3rd Generation
   Anastrozole
    D00960  Anastrozole (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D00960  Anastrozole (JAN/USP/INN)
Drug groups [BR:br08330]
Antineoplastic
  DG01596  Aromatase inhibitor
   D00960  Anastrozole
  DG01524  Triazole antineoplastic
   D00960  Anastrozole
Metabolizing enzyme inhibitor
  DG01634  CYP1A2 inhibitor
   D00960  Anastrozole
  DG01643  CYP2C9 inhibitor
   D00960  Anastrozole
  DG02852  CYP3A/CYP3A4 inhibitor
   DG01522  CYP3A4 inhibitor
    D00960  Anastrozole
Drug classes [BR:br08332]
Antineoplastic
  DG01596  Aromatase inhibitor
   D00960  Anastrozole
Target-based classification of drugs [BR:br08310]
Enzymes
  Oxidoreductases (EC1)
   Cytochrome P450
    CYP19A1 (ARO)
     D00960  Anastrozole (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00960
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00960
Pharmacogenomic biomarkers [br08341.html]
Somatic variations in targeted cancer therapies
  D00960

Other DBs

CAS:	120511-73-1

PubChem:

7848023

ChEBI:

2704

LigandBox:

D00960

NIKKAJI:

J592.428F

KCF data

ATOM        22
            1   C8x C     8.8900  -10.7800
            2   C8y C     8.8900  -12.1800
            3   C8x C    10.1024  -12.8800
            4   C8y C    11.3149  -12.1800
            5   C8x C    11.3149  -10.7800
            6   C8y C    10.1024  -10.0800
            7   C1b C    10.1024   -8.6802
            8   N4y N    11.2980   -7.9898
            9   C1d C     7.6776  -12.8800
            10  C1d C    12.5460  -12.8910
            11  C3b C    13.7584  -13.5910
            12  C1a C    11.8467  -14.1019
            13  C1a C    13.2468  -11.6774
            14  N3a N    14.9709  -14.2910
            15  C3b C     6.4651  -13.5800
            16  C1a C     6.9834  -11.6773
            17  C1a C     8.3830  -14.1021
            18  N3a N     5.2527  -14.2800
            19  N5x N    12.6279   -8.4272
            20  C8x C    13.4536   -7.2966
            21  N5x N    12.6335   -6.1620
            22  C8x C    11.3009   -6.5913
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 1
            9     2   9 1
            10    4  10 1
            11   10  11 1
            12   10  12 1
            13   10  13 1
            14   11  14 3
            15    9  15 1
            16    9  16 1
            17    9  17 1
            18   15  18 3
            19    8  19 1
            20   19  20 2
            21   20  21 1
            22   21  22 2
            23    8  22 1