Letrozole


Entry
D00964                      Drug                                   
Name
Letrozole (JAN/USP/INN);
Femara (TN)
Product
FEMARA (Novartis Pharmaceuticals Corporation)
  Generic
LETROZOLE (A-S Medication Solutions), LETROZOLE (Accord Healthcare), LETROZOLE (Aurobindo Pharma Limited), LETROZOLE (AvKARE), LETROZOLE (AvPAK), LETROZOLE (Breckenridge Pharmaceutical), LETROZOLE (Bryant Ranch Prepack), LETROZOLE (Bryant Ranch Prepack), LETROZOLE (Chartwell RX), LETROZOLE (Dr. Reddy's Laboratories Limited), LETROZOLE (Jiangsu Hengrui Pharmaceuticals), LETROZOLE (Natco Pharma Limited), LETROZOLE (Proficient Rx LP), LETROZOLE (Teva Pharmaceuticals USA), LETROZOLE (Yiling Pharmaceutical)
Formula
C17H11N5
Exact mass
285.1014
Mol weight
285.3027
Structure
Simcomp
Class
Antineoplastic
 DG01596  Aromatase inhibitor
 DG01524  Triazole antineoplastic
Metabolizing enzyme substrate
 DG01638  CYP2A6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01525  CYP2A6 inhibitor
Remark
Same as: C08163
Therapeutic category: 4291
ATC code: L02BG04
Product: D00964<JP/US>
Product (mixture): D11068<US>
Efficacy
Antineoplastic, Estrogen biosynthesis inhibitor
  Disease
Breast cancer, postmenopausal (HR-positive) [DS:H00031]
Comment
Aromatase inhibitor
Target
CYP19A1 (ARO) [HSA:1588] [KO:K07434]
  Pathway
hsa00140  Steroid hormone biosynthesis
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2A6 [HSA:1548]
Interaction
CYP inhibition: CYP2A6 [HSA:1548]
Structure map
map07043  Antineoplastics - hormones
Other map
map01522  Endocrine resistance
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L02 ENDOCRINE THERAPY
   L02B HORMONE ANTAGONISTS AND RELATED AGENTS
    L02BG Aromatase inhibitors
     L02BG04 Letrozole
      D00964  Letrozole (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Aromatase Inhibitors, 3rd Generation
   Letrozole
    D00964  Letrozole (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D00964  Letrozole (JAN/USP/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01596  Aromatase inhibitor
   D00964  Letrozole
  DG01524  Triazole antineoplastic
   D00964  Letrozole
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   D00964  Letrozole
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00964  Letrozole
 Metabolizing enzyme inhibitor
  DG01525  CYP2A6 inhibitor
   D00964  Letrozole
Drug classes [BR:br08332]
 Antineoplastic
  DG01596  Aromatase inhibitor
   D00964  Letrozole
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Cytochrome P450
    CYP19A1 (ARO)
     D00964  Letrozole (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00964
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00964
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D00964
Other DBs
CAS: 112809-51-5
PubChem: 7848027
ChEBI: 6413
LigandBox: D00964
NIKKAJI: J390.644B
KCF data

ATOM        22
            1   C1c C    25.6900  -19.1281
            2   C8y C    26.8966  -19.8333
            3   C8y C    24.4834  -19.8276
            4   N4y N    25.6957  -17.7232
            5   C8x C    26.8907  -21.2381
            6   C8x C    28.1149  -19.1338
            7   C8x C    24.4834  -21.2266
            8   C8x C    23.2710  -19.1222
            9   C8x C    24.5650  -16.9072
            10  N5x N    26.8326  -16.9072
            11  C8x C    28.1033  -21.9376
            12  C8x C    29.3273  -19.8450
            13  C8x C    23.2710  -21.9259
            14  C8x C    22.0527  -19.8276
            15  N5x N    25.0022  -15.5723
            16  C8x C    26.4069  -15.5723
            17  C8y C    29.3216  -21.2498
            18  C8y C    22.0527  -21.2266
            19  C3b C    30.5165  -21.9435
            20  C3b C    20.8402  -21.9202
            21  N3a N    31.7172  -22.6371
            22  N3a N    19.6394  -22.6430
BOND        24
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     4  10 1
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 2
            14    9  15 2
            15   10  16 2
            16   11  17 2
            17   13  18 2
            18   17  19 1
            19   18  20 1
            20   19  21 3
            21   20  22 3
            22   12  17 1
            23   14  18 1
            24   15  16 1