Entry

D00969                      Drug

Name

Meloxicam (JAN/USP/INN);
Mobic (TN)

Product

MELOXICAM (Avondale Pharmaceuticals), ANJESO (Baudax Bio), MOBIC (Boehringer Ingelheim Pharmaceuticals), VIVLODEX (Egalet US)

Generic

MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (A-S Medication Solutions), MELOXICAM (Advanced Rx Pharmacy of Tennessee), MELOXICAM (Advanced Rx Pharmacy of Tennessee), MELOXICAM (Advanced Rx Pharmacy of Tennessee), MELOXICAM (Advanced Rx Pharmacy of Tennessee), MELOXICAM (Advanced Rx Pharmacy of Tennessee), MELOXICAM (Advanced Rx Pharmacy of Tennessee), MELOXICAM (American Health Packaging), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Aphena Pharma Solutions - Tennessee), MELOXICAM (Asclemed USA), MELOXICAM (Asclemed USA), MELOXICAM (Aurobindo Pharma Limited), MELOXICAM (AvPAK), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Bryant Ranch Prepack), MELOXICAM (Cadila Healthcare Limited), MELOXICAM (Carlsbad Technology), MELOXICAM (Cipla USA), MELOXICAM (Clinical Solutions Wholesale), MELOXICAM (Denton Pharma), MELOXICAM (Denton Pharma), MELOXICAM (Direct Rx), MELOXICAM (Direct_Rx), MELOXICAM (Direct_Rx), MELOXICAM (Direct_Rx), MELOXICAM (Emerald Therapeutics), MELOXICAM (Exelan Pharmaceuticals), MELOXICAM (Glenmark Pharmaceuticals), MELOXICAM (Golden State Medical Supply), MELOXICAM (International Laboratories), MELOXICAM (Lake Erie Medical DBA Quality Care Products LLC), MELOXICAM (Lake Erie Medical DBA Quality Care Products LLC), MELOXICAM (Lupin Pharmaceuticals), MELOXICAM (Lupin Pharmaceuticals), MELOXICAM (Medsource Pharmaceuticals), MELOXICAM (NCS HealthCare of KY), MELOXICAM (Northwind Pharmaceuticals), MELOXICAM (Northwind Pharmaceuticals), MELOXICAM (Novitium Pharma LLC), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (NuCare Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (PD-Rx Pharmaceuticals), MELOXICAM (Preferred Pharmaceuticals), MELOXICAM (Preferred Pharmaceuticals), MELOXICAM (Preferred Pharmaceuticals), MELOXICAM (Proficient Rx LP), MELOXICAM (Proficient Rx LP), MELOXICAM (QPharma), MELOXICAM (QPharma), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (REMEDYREPACK), MELOXICAM (RPK Pharmaceuticals), MELOXICAM (RPK Pharmaceuticals), MELOXICAM (RPK Pharmaceuticals), MELOXICAM (RedPharm Drug), MELOXICAM (RedPharm Drug), MELOXICAM (RedPharm Drug), MELOXICAM (RedPharm Drug), MELOXICAM (RedPharm Drug), MELOXICAM (Rising Pharma Holdings), MELOXICAM (St. Mary's Medical Park Pharmacy), MELOXICAM (St. Mary's Medical Park Pharmacy), MELOXICAM (St. Mary's Medical Park Pharmacy), MELOXICAM (Strides Pharma Science Limited), MELOXICAM (Unichem Pharmaceuticals (USA)), MELOXICAM (Unit Dose Services), MELOXICAM (XLCare Pharmaceuticals), MELOXICAM (Zydus Pharmaceuticals (USA)), NUDROXIPAK M-15 (NuCare Pharmceuticals)

Formula

C14H13N3O4S2

Exact mass

351.0347

Mol weight

351.4007

Structure

Simcomp

Class

Anti-inflammatory
DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01910  Anti-inflammatory drug, oxicams
  DG01922  Selective COX2 inhibitor
Metabolizing enzyme substrate
DG01642  CYP2C9 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Same as:

C08169

Therapeutic category:

1149

ATC code:

M01AC06

Product:

D00969<JP/US>

Product (mixture):

D12270<US>

Efficacy

Analgesic, Anti-inflammatory, COX-2 inhibitor

Comment

Oxicams

Target

PTGS2 (COX2) [HSA:5743] [KO:K11987]

Pathway

hsa00590

Arachidonic acid metabolism

Metabolism

Enzyme: CYP2C9 [HSA:1559]; CYP3A4 [HSA:1576]

Interaction

Structure map

map07219

Cyclooxygenase inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AC Oxicams
     M01AC06 Meloxicam
      D00969  Meloxicam (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Meloxicam
    D00969  Meloxicam (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00969  Meloxicam (JAN/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01910  Anti-inflammatory drug, oxicams
    D00969  Meloxicam
   DG01922  Selective COX2 inhibitor
    D00969  Meloxicam
Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   D00969  Meloxicam
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00969  Meloxicam
Drug classes [BR:br08332]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00969  Meloxicam
   D00969  Meloxicam
Target-based classification of drugs [BR:br08310]
Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS2 (COX2)
     D00969  Meloxicam (JAN/USP/INN) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D00969
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D00969
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D00969
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00969

Other DBs

CAS:	71125-38-7

PubChem:

7848032

ChEBI:

6741

PDB-CCD:

MXM[PDBj]

LigandBox:

D00969

NIKKAJI:

J22.773K

KCF data

ATOM        23
            1   C8y C    29.1386  -17.3775
            2   C8y C    29.1152  -18.7625
            3   C8y C    30.3483  -16.6996
            4   C8x C    27.9406  -16.6586
            5   S2x S    30.3015  -19.4695
            6   C8x C    27.9055  -19.4403
            7   C8y C    31.5345  -17.4125
            8   O1a O    30.3717  -15.3088
            9   C8x C    26.7310  -17.3481
            10  N4y N    31.5112  -18.7975
            11  O3c O    31.3591  -20.4571
            12  O3c O    29.1211  -20.5273
            13  C8x C    26.7135  -18.7391
            14  C5a C    32.7500  -16.7347
            15  C1a C    32.7149  -19.5105
            16  N1b N    33.9480  -17.4534
            17  O5a O    32.7734  -15.3438
            18  C8y C    35.1635  -16.7755
            19  N5x N    36.4943  -17.1641
            20  S2x S    35.1230  -15.3776
            21  C8x C    37.2806  -16.0189
            22  C8y C    36.4368  -14.9158
            23  C1a C    36.8219  -13.5763
BOND        25
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    5  12 2
            12    6  13 2
            13    7  14 1
            14   10  15 1
            15   14  16 1
            16   14  17 2
            17   16  18 1
            18   18  19 2
            19   18  20 1
            20   19  21 1
            21   20  22 1
            22   22  23 1
            23    7  10 1
            24    9  13 1
            25   21  22 2