Entry

D00970                      Drug

Name

Naproxen sodium (USP);
Anaprox (TN)

Product

NAPRELAN (ALMATICA PHARMA)

Generic

NAPROXEN SODIUM (A-S Medication Solutions), NAPROXEN SODIUM (A-S Medication Solutions), NAPROXEN SODIUM (Actavis Pharma), NAPROXEN SODIUM (Alvogen), NAPROXEN SODIUM (Amneal Pharmaceuticals of New York LLC), NAPROXEN SODIUM (Aurobindo Pharma Limited), NAPROXEN SODIUM (AvKARE), NAPROXEN SODIUM (AvPAK), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (Bryant Ranch Prepack), NAPROXEN SODIUM (DIRECT RX), ANAPROX (DIRECT RX), NAPROXEN (DIRECT RX), NAPROXEN SODIUM (Denton Pharma), NAPROXEN SODIUM (Direct Rx), NAPROXEN SODIUM (Dr. Reddy's Laboratories), NAPROXEN (Granules India), NAPROXEN (Granules Pharmaceuticals), NAPROXEN SODIUM (Medsource Pharmaceuticals), NAPROXEN SODIUM (NuCare Pharmaceuticals), NAPROXEN SODIUM (NuCare Pharmaceuticals), NAPROXEN SODIUM (PD-Rx Pharmaceuticals), NAPROXEN SODIUM (Preferred Pharmaceuticals), NAPROXEN SODIUM (Proficient Rx LP), NAPROXEN SODIUM (Proficient Rx LP), NAPROXEN SODIUM (Proficient Rx LP), NAPROXEN SODIUM (Quality Care Products), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (REMEDYREPACK), NAPROXEN SODIUM (RPK Pharmaceuticals), NAPROXEN SODIUM (SA3), NAPROXEN SODIUM (ScieGen Pharmaceuticals)

Formula

C14H13O3. Na

Exact mass

252.0762

Mol weight

252.241

Structure

Simcomp

Class

Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives

Remark

ATC code:

G02CC02 M01AE02 M02AA12

Chemical structure group:

DG00455

Product (DG00455):

D00118<JP/US> D00970<US>

Product (mixture):

D11577<US>

Efficacy

Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor

Disease

Rheumatoid arthritis [DS:H00630]
Ankylosing spondylitis [DS:H01674]
Polyarticular juvenile idiopathic arthritis [DS:H01672]
Acute gout [DS:H01532]

Comment

Propionic acid derivative

Target

PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]

Pathway

hsa00590

Arachidonic acid metabolism

Interaction

Structure map

map07048

Antimigraines

map07114

Naphthalene family

map07219

Cyclooxygenase inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CC Antiinflammatory products for vaginal administration
     G02CC02 Naproxen
      D00970  Naproxen sodium (USP) <US>
M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE02 Naproxen
      D00970  Naproxen sodium (USP) <US>
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA12 Naproxen
      D00970  Naproxen sodium (USP) <US>
USP drug classification [BR:br08302]
Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Naproxen
    D00970  Naproxen sodium (USP)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01908  Anti-inflammatory drug, propionic acid derivatives
    DG00455  Naproxen
     D00970  Naproxen sodium
Drug classes [BR:br08332]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D00970  Naproxen sodium
Target-based classification of drugs [BR:br08310]
Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D00970  Naproxen sodium (USP) <US>
    PTGS2 (COX2)
     D00970  Naproxen sodium (USP) <US>
Rx-to-OTC switch list in the USA [br08315.html]
D00970
Drug groups [BR:br08330]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01908  Anti-inflammatory drug, propionic acid derivatives
    DG00455  Naproxen

Other DBs

CAS:	26159-34-2

PubChem:

7848033

ChEBI:

7477

LigandBox:

D00970

NIKKAJI:

J17.059C

KCF data

ATOM        18
            1   C8y C    23.5997  -20.0988
            2   C8y C    23.5997  -21.4993
            3   C8x C    24.7901  -19.3985
            4   C8x C    22.3393  -19.3985
            5   C8x C    22.3393  -22.1995
            6   C8x C    24.7901  -22.1995
            7   C8y C    25.9806  -20.0988
            8   C8x C    21.1489  -20.0988
            9   C8y C    21.1489  -21.4993
            10  C8x C    25.9806  -21.4993
            11  C1c C    27.2410  -19.3985
            12  O2a O    19.9584  -22.1995
            13  C6a C    28.4314  -20.0988
            14  C1a C    27.2410  -17.9980
            15  C1a C    18.6980  -21.4993
            16  O6a O    28.4314  -21.4993
            17  O6a O    29.6219  -19.3985 #-
            18  Z   Na   31.5125  -19.3985 #+
BOND        18
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     5   9 2
            9     6  10 2
            10    7  11 1
            11    9  12 1
            12   11  13 1
            13   11  14 1 #Down
            14   12  15 1
            15   13  16 2
            16   13  17 1
            17    7  10 1
            18    8   9 1