Entry

D00975                      Drug

Name

Dexamethasone sodium phosphate (JAN/USP);
Dalalone (TN);
Maxidex (TN)

Product

Generic

DEXAMETHASONE SODIUM PHOSPHATE (A-S Medication Solutions), DEXAMETHASONE SODIUM PHOSPHATE (A-S Medication Solutions), DEXAMETHASONE SODIUM PHOSPHATE (A-S Medication Solutions), DEXAMETHASONE SODIUM PHOSPHATE (A-S Medication Solutions), DEXAMETHASONE SODIUM PHOSPHATE (A-S Medication Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Amneal Pharmaceuticals LLC), DEXAMETHASONE SODIUM PHOSPHATE (Amneal Pharmaceuticals LLC), DEXAMETHASONE SODIUM PHOSPHATE (Asclemed USA), DEXAMETHASONE SODIUM PHOSPHATE (Asclemed USA), DEXAMETHASONE SODIUM PHOSPHATE (AuroMedics Pharma LLC), DEXAMETHASONE SODIUM PHOSPHATE (AuroMedics Pharma LLC), DEXAMETHASONE SODIUM PHOSPHATE (AuroMedics Pharma LLC), DEXAMETHASONE SODIUM PHOSPHATE (Bausch & Lomb Incorporated), DEXAMETHASONE SODIUM PHOSPHATE (Cardinal Health), DEXAMETHASONE SODIUM PHOSPHATE (Cardinal Health), DEXAMETHASONE SODIUM PHOSPHATE (Cardinal Health), DEXAMETHASONE SODIUM PHOSPHATE (Civica), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (Fresenius Kabi USA), DEXAMETHASONE SODIUM PHOSPHATE (General Injectables & Vaccines), DEXAMETHASONE SODIUM PHOSPHATE (General Injectables and Vaccines), DEXAMETHASONE SODIUM PHOSPHATE (General Injectables and Vaccines), DEXAMETHASONE SODIUM PHOSPHATE (Gland Pharma Limited), DEXAMETHASONE SODIUM PHOSPHATE (HF Acquisition Co LLC), DEXAMETHASONE SODIUM PHOSPHATE (HF Acquisition Co LLC), DEXAMETHASONE SODIUM PHOSPHATE (HF Acquisition Co LLC), DEXAMETHASONE SODIUM PHOSPHATE (HF Acquisition Co LLC), DEXAMETHASONE SODIUM PHOSPHATE (HF Acquisition Co LLC), DEXAMETHASONE SODIUM PHOSPHATE (HF Acquisition Co LLC), DEXAMETHASONE SODIUM PHOSPHATE (Henry Schein), DEXAMETHASONE SODIUM PHOSPHATE (Henry Schein), DEXAMETHASONE SODIUM PHOSPHATE (Henry Schein), DEXAMETHASONE SODIUM PHOSPHATE (Hikma Pharmaceuticals USA), VIADOX (IT3 Medical LLC), CORTAREN CORTICOSTEROID/ANTI-INFLAMMATORY SYSTEM (IT3 Medical LLC), NEUROMAQUEL NEUROMA/ANTI-INFLAMMATORY SYSTEM (IT3 Medical LLC), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Medical Purchasing Solutions), DEXAMETHASONE SODIUM PHOSPHATE (Mylan Institutional LLC), DEXAMETHASONE SODIUM PHOSPHATE (Mylan Institutional LLC), DEXAMETHASONE SODIUM PHOSPHATE (Phlow Corporation), DEXAMETHASONE SODIUM PHOSPHATE (REMEDYREPACK), DEXAMETHASONE SODIUM PHOSPHATE (REMEDYREPACK), DEXAMETHASONE SODIUM PHOSPHATE (REMEDYREPACK), DEXAMETHASONE SODIUM PHOSPHATE (REMEDYREPACK), DEXAMETHASONE SODIUM PHOSPHATE (Somerset Therapeutics), DEXAMETHASONE SODIUM PHOSPHATE (Somerset Therapeutics), DEXAMETHASONE SODIUM PHOSPHATE (Somerset Therapeutics)

Formula

C22H28FO8P. 2Na

Exact mass

516.1301

Mol weight

516.4046

Structure

Simcomp

Class

Anti-inflammatory
DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inducer
DG02853  CYP3A/CYP3A4 inducer
  DG01635  CYP3A4 inducer

Remark

Same as:

C08175

Therapeutic category:

1315 1329 2454

ATC code:

A01AC02 C05AA09 D07AB19 D07XB05 D10AA03 H02AB02 R01AD03 S01BA01 S01CB01 S02BA06 S03BA01

Chemical structure group:

DG00011

Product (DG00011):

D00292<JP/US> D00975<JP/US> D01510<JP> D01615<JP> D01632<JP> D01948<JP> D07073<JP>

Efficacy

Anti-inflammatory, Glucocorticoid receptor agonist

Disease

Primary or secondary adrenocortical insufficiency [DS:H01598]
Congenital adrenal hyperplasia [DS:H00216]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Acute gouty arthritis [DS:H01532]
Psoriatic arthritis [DS:H01507]
Ankylosing spondylitis [DS:H01674]
Systemic lupus erythematosus [DS:H00080]
Pemphigus [DS:H01648]
Severe erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Seborrheic dermatitis [DS:H01652]
Psoriasis [DS:H01656]
Mycosis fungoides [DS:H01463]
Bronchial asthma [DS:H00079]
Contact dermatitis [DS:H01357]
Atopic dermatitis [DS:H01358]
Seasonal or perennial allergic rhinitis [DS:H01360]
Herpes zoster ophthalmicus [DS:H00366]
Optic neuritis [DS:H01717]
Ulcerative colitis [DS:H01466]
Pulmonary tuberculosis [DS:H00342]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Nephrotic syndrome [DS:H01657]

Target

NR3C1 (GR) [HSA:2908] [KO:K05771]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Metabolism

Enzyme: CYP3A4 [HSA:1576]

Interaction

CYP induction: CYP3A4 [HSA:1576]

Structure map

map07225

Glucocorticoid and mineralocorticoid receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC02 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA09 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AB Corticosteroids, moderately potent (group II)
     D07AB19 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XB Corticosteroids, moderately potent, other combinations
     D07XB05 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA03 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB02 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD03 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA01 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB01 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA06 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA01 Dexamethasone
      D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Dexamethasone
   D00975  Dexamethasone sodium phosphate (JAN/USP)
Inflammatory Bowel Disease Agents
  Glucocorticoids
   Dexamethasone
    D00975  Dexamethasone sodium phosphate (JAN/USP)
Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Dexamethasone
     D00975  Dexamethasone sodium phosphate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1315  Ophthalmic cortisones
     D00975  Dexamethasone sodium phosphate (JAN/USP)
   132  Otic and nasal agents
    1329  Others
     D00975  Dexamethasone sodium phosphate (JAN/USP)
2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2454  Fluorinated adrenocorticotropic hormones
     D00975  Dexamethasone sodium phosphate (JAN/USP)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00011  Dexamethasone
     D00975  Dexamethasone sodium phosphate
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00011  Dexamethasone
     D00975  Dexamethasone sodium phosphate
Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    DG00011  Dexamethasone
     D00975  Dexamethasone sodium phosphate
Drug classes [BR:br08332]
Anti-inflammatory
  DG01955  Corticosteroid
   D00975  Dexamethasone sodium phosphate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00975  Dexamethasone sodium phosphate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00975
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00011  Dexamethasone
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00011  Dexamethasone
Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    DG00011  Dexamethasone

Other DBs

CAS:

2392-39-4

PubChem:

7848038

ChEBI:

4462

LigandBox:

D00975

NIKKAJI:

J7.881F

KCF data

ATOM        34
            1   C1y C    20.5509  -18.6771
            2   C1y C    19.3622  -19.3588
            3   C1z C    20.5626  -17.2961
            4   C1x C    22.9399  -18.7004
            5   C1z C    18.1794  -18.6655
            6   C1x C    19.3622  -20.7281
            7   C1z C    21.7686  -16.6144
            8   C1x C    19.3855  -16.6144
            9   C1a C    20.5567  -15.9269
            10  C1y C    22.9514  -17.3253
            11  C1z C    16.9908  -19.3471
            12  C1y C    18.1910  -17.2961
            13  X   F    18.1677  -20.0289
            14  C1x C    18.1677  -21.4098
            15  C5a C    21.7745  -15.2451
            16  O1a O    23.0913  -16.2589
            17  C1a C    24.2741  -17.1681
            18  C2y C    16.9849  -20.7222
            19  C2x C    15.8021  -18.6596
            20  C1a C    16.9791  -17.9662
            21  O1a O    17.0025  -16.6028
            22  C1b C    22.9573  -14.5575
            23  O5a O    20.5743  -14.5575
            24  C2x C    15.8021  -21.4040
            25  C2x C    14.6135  -19.3471
            26  O2b O    24.1401  -15.2334
            27  C5x C    14.6135  -20.7222
            28  P1b P    25.2763  -14.4585
            29  O5x O    13.4190  -21.3981
            30  O1c O    26.4534  -15.1461
            31  O1c O    26.4068  -13.6836 #-
            32  O1c O    24.5014  -13.3223 #-
            33  Z   Na   28.9880  -14.9538 #+
            34  Z   Na   28.9181  -18.1935 #+
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    5  13 1 #Down
            13    6  14 1
            14    7  15 1 #Up
            15    7  16 1 #Down
            16   10  17 1 #Down
            17   11  18 1
            18   11  19 1
            19   11  20 1 #Up
            20   12  21 1 #Up
            21   15  22 1
            22   15  23 2
            23   18  24 2
            24   19  25 2
            25   22  26 1
            26   24  27 1
            27   26  28 1
            28   27  29 2
            29   28  30 2
            30   28  31 1
            31   28  32 1
            32    7  10 1
            33    8  12 1
            34   14  18 1
            35   25  27 1