Entry

D00979                      Drug

Name

Methylprednisolone acetate (JAN/USP);
Depo-medrol (TN)

Product

POINT OF CARE L2 (NuCare Pharmaceuticals), POINT OF CARE L5 (NuCare Pharmaceuticals), DEPO-MEDROL (A-S Medication Solutions), DEPO-MEDROL (A-S Medication Solutions), DEPO-MEDROL (A-S Medication Solutions), DEPO-MEDROL (A-S Medication Solutions), DEPO-MEDROL (A-S Medication Solutions), DEPO-MEDROL (Asclemed USA), DEPO-MEDROL (Pharmacia & Upjohn Company LLC), DEPO-MEDROL (Pharmacia & Upjohn Company LLC), DEPO-MEDROL (Pharmacia & Upjohn Company LLC)

Generic

METHYLPREDNISOLONE ACETATE (A-S Medication Solutions), METHYLPREDNISOLONE ACETATE (A-S Medication Solutions), METHYLPREDNISOLONE ACETATE (A-S Medication Solutions), METHYLPREDNISOLONE ACETATE (Amneal Pharmaceuticals LLC), METHYLPREDNISOLONE ACETATE (Amneal Pharmaceuticals LLC), METHYLPREDNISOLONE ACETATE (Amneal Pharmaceuticals NY LLC), METHYLPREDNISOLONE ACETATE (HF Acquisition Co LLC), METHYLPREDNISOLONE ACETATE (Northstar RxLLC), METHYLPREDNISOLONE ACETATE (Northstar RxLLC), METHYLPREDNISOLONE ACETATE (Proficient Rx LP), METHYLPREDNISOLONE ACETATE (Sagent Pharmaceuticals), METHYLPREDNISOLONE ACETATE (Teva Parenteral Medicines), METHYLPREDNISOLONE ACETATE (Teva Parenteral Medicines)

Formula

C24H32O6

Exact mass

416.2199

Mol weight

416.5073

Structure

Simcomp

Class

Anti-inflammatory
DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

Same as:

C08179

Therapeutic category:

2456

ATC code:

D07AA01 D10AA02 H02AB04

Chemical structure group:

DG00410

Product (DG00410):

D00407<JP/US> D00751<JP/US> D00979<JP/US>

Efficacy

Anti-inflammatory, Glucocorticoid receptor agonist

Disease

Asthma [DS:H00079]
Atopic dermatitis [DS:H01358]
Contact dermatitis [DS:H01357]
Seasonal or perennial allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Mcosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Stevens-Johnson syndrome [DS:H01694]
Congenital adrenal hyperplasia [DS:H00216]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Diamond blackfan anemia [DS:H00237]
Multiple sclerosis [DS:H01490]
Temporal arteritis [DS:H01698]
Pulmonary tuberculosis [DS:H00342]
Ankylosing spondylitis [DS:H01674]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Dermatomyositis and polymyositis [DS:H01604]
Systemic lupus erythematosus [DS:H00080]
Discoid lupus erythematosus [DS:H01595]
Lichen planus [DS:H01654]

Target

NR3C1 (GR) [HSA:2908] [KO:K05771]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Metabolism

Enzyme: CYP3A4 [HSA:1576]

Interaction

Structure map

map07225

Glucocorticoid and mineralocorticoid receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA01 Methylprednisolone
      D00979  Methylprednisolone acetate (JAN/USP) <JP/US>
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AA Corticosteroids, combinations for treatment of acne
     D10AA02 Methylprednisolone
      D00979  Methylprednisolone acetate (JAN/USP) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB04 Methylprednisolone
      D00979  Methylprednisolone acetate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, High Potency
    Methylprednisolone
     D00979  Methylprednisolone acetate (JAN/USP)
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Methylprednisolone
   D00979  Methylprednisolone acetate (JAN/USP)
Inflammatory Bowel Disease Agents
  Glucocorticoids
   Methylprednisolone
    D00979  Methylprednisolone acetate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00979  Methylprednisolone acetate (JAN/USP)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00410  Methylprednisolone
     D00979  Methylprednisolone acetate
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00410  Methylprednisolone
     D00979  Methylprednisolone acetate
Drug classes [BR:br08332]
Anti-inflammatory
  DG01955  Corticosteroid
   D00979  Methylprednisolone acetate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00979  Methylprednisolone acetate (JAN/USP) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D00979
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00410  Methylprednisolone
Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00410  Methylprednisolone

Other DBs

CAS:

53-36-1

PubChem:

7848042

ChEBI:

6889

LigandBox:

D00979

NIKKAJI:

J4.144K

KCF data

ATOM        30
            1   C2x C     6.3700  -24.5700
            2   C5x C     6.3700  -25.9700
            3   C2x C     7.5824  -26.6700
            4   C2y C     8.7949  -25.9700
            5   C1z C     8.7949  -24.5700
            6   C2x C     7.5824  -23.8700
            7   C1y C    10.0073  -26.6700
            8   C1x C    11.2197  -25.9700
            9   C1y C    11.2197  -24.5700
            10  C1y C    10.0073  -23.8700
            11  C1y C    12.4322  -23.8700
            12  C1z C    12.4322  -22.4700
            13  C1x C    11.2197  -21.7700
            14  C1y C    10.0073  -22.4700
            15  C1x C    14.8570  -23.8700
            16  C1x C    14.8570  -22.4700
            17  C1z C    13.6446  -21.7700
            18  O5x O     5.1576  -26.6700
            19  C1a C     8.7949  -23.1700
            20  O1a O     8.7969  -21.7712
            21  C1a C    12.4322  -21.0700
            22  C5a C    13.6446  -20.0900
            23  C1a C    10.0073  -28.0700
            24  O1a O    14.8570  -21.0700
            25  C1b C    14.8611  -19.3877
            26  O5a O    12.4362  -19.3923
            27  O7a O    16.0586  -20.0792
            28  C7a C    17.2449  -19.3943
            29  C1a C    18.4367  -20.0826
            30  O6a O    17.2451  -17.9902
BOND        33
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26    7  23 1 #Down
            27   17  24 1 #Down
            28   22  25 1
            29   22  26 2
            30   25  27 1
            31   27  28 1
            32   28  29 1
            33   28  30 2