Entry

D00981                      Drug

Name

Prednisolone sodium phosphate (JP18/USP);
Pediapred (TN)

Product

ORAPRED (Concordia Pharmaceuticals), PEDIAPRED (Royal Pharmaceuticals), PREDNISOLONE SODIUM PHOSPHATE (Seton Pharmaceuticals)

Generic

PREDNISOLONE SODIUM PHOSPHATE (A-S Medication Solutions), PREDNISOLONE SODIUM PHOSPHATE (A-S Medication Solutions), PREDNISOLONE SODIUM PHOSPHATE (ATLANTIC BIOLOGICALS CORP.), PREDNISOLONE SODIUM PHOSPHATE (Amneal Pharmaceuticals LLC), PREDNISOLONE SODIUM PHOSPHATE (Bausch & Lomb Incorporated), PREDNISOLONE SODIUM PHOSPHATE ORAL SOLUTION (BioComp Pharma), PREDNISOLONE SODIUM PHOSPHATE (Chartwell RX), PREDNISOLONE SODIUM PHOSPHATE (Edenbridge Pharmaceuticals LLC.), PREDNISOLONE SODIUM PHOSPHATE (Lohxa), PREDNISOLONE SODIUM PHOSPHATE (Morton Grove Pharmaceuticals), PREDNISOLONE SODIUM PHOSPHATE (PINNACLE PHARMA LLC), PREDNISOLONE SODIUM PHOSPHATE (Pharmaceutical Associates), PREDNISOLONE SODIUM PHOSPHATE (Pharmaceutical Associates), PREDNISOLONE SODIUM PHOSPHATE (Pharmaceutical Associates), PREDNISOLONE SODIUM PHOSPHATE (Pharmaceutical Associates), PREDNISOLONE SODIUM PHOSPHATE (Prasco Laboratories), PREDNISOLONE SODIUM PHOSPHATE (Preferred Pharmaceuticals), PREDNISOLONE SODIUM PHOSPHATE (Proficient Rx LP), PREDNISOLONE SODIUM PHOSPHATE (RedPharm Drug)

Formula

C21H27O8P. 2Na

Exact mass

484.1239

Mol weight

484.3876

Structure

Simcomp

Class

Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid

Remark

Therapeutic category:

2456

ATC code:

A07EA01 C05AA04 D07AA03 D07XA02 H02AB06 R01AD02 S01BA04 S01CB02 S02BA03 S03BA02

Chemical structure group:

DG00093

Product (DG00093):

D00472<JP/US> D00980<JP/US> D00981<JP/US> D01239<JP> D03301<JP>

Product (mixture):

D11699<US>

Efficacy

Anti-inflammatory, Glucocorticoid receptor agonist

Disease

Atopic dermatitis [DS:H01358]
Allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Contact dermatitis [DS:H01357]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Severe erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Congenital adrenal hyperplasia [DS:H00216]
Primary or secondary adrenocortical insufficiency [DS:H01598]
Crohn's disease [DS:H00286]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Diamond-Blackfan anemia [DS:H00237]
Pure red cell aplasia [DS:H01586]
Multiple sclerosis [DS:H01490]
Acute or chronic solid organ rejection [DS:H00083]
Chronic obstructive pulmonary disease [DS:H01714]
Allergic bronchopulmonary aspergillosis [DS:H01328]
Asthma [DS:H00079]
Pulmonary tuberculosis [DS:H00342]
Hypersensitivity pneumonitis [DS:H00346]
Idiopathic bronchiolitis obliterans [DS:H01873]
Idiopathic pulmonary fibrosis [DS:H01299]
Pneumocystis carinii pneumonia [DS:H01521]
Nephrotic syndrome [DS:H01657]
Ankylosing spondylitis [DS:H01674]
Dermatomyositis and polymyositis [DS:H01604]
Polymyalgia rheumatica [DS:H01606]
Temporal arteritis [DS:H01698]
Psoriatic arthritis [DS:H01507]
Relapsing polychondritis [DS:H01758]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Sjogren's Syndrome [DS:H01502]
Systemic lupus erythematosus [DS:H00080]
Trichinosis with neurologic or myocardial involvement [DS:H01099]

Target

NR3C1 (GR) [HSA:2908] [KO:K05771]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Interaction

Structure map

map07225

Glucocorticoid and mineralocorticoid receptor agonists/antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA01 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA04 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA03 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA02 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB06 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AD Corticosteroids
     R01AD02 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA04 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB02 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA03 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03B CORTICOSTEROIDS
    S03BA Corticosteroids
     S03BA02 Prednisolone
      D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Prednisolone
   D00981  Prednisolone sodium phosphate (JP18/USP)
Inflammatory Bowel Disease Agents
  Glucocorticoids
   Prednisolone
    D00981  Prednisolone sodium phosphate (JP18/USP)
Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Prednisolone
     D00981  Prednisolone sodium phosphate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2456  Prednisolones
     D00981  Prednisolone sodium phosphate (JP18/USP)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone
     D00981  Prednisolone sodium phosphate
Drug classes [BR:br08332]
Anti-inflammatory
  DG01955  Corticosteroid
   D00981  Prednisolone sodium phosphate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00981  Prednisolone sodium phosphate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00981  Prednisolone sodium phosphate
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00093  Prednisolone

Other DBs

CAS:

125-02-0

PubChem:

7848044

ChEBI:

8379

LigandBox:

D00981

NIKKAJI:

J5.364C

KCF data

ATOM        32
            1   C2x C     3.4829  -12.1384
            2   C5x C     3.4829  -13.5014
            3   C2x C     4.6633  -14.1829
            4   C2y C     5.8437  -13.5014
            5   C1z C     5.8437  -12.1384
            6   C2x C     4.6633  -11.4568
            7   C1x C     7.0241  -14.1829
            8   C1x C     8.2045  -13.5014
            9   C1y C     8.2045  -12.1384
            10  C1y C     7.0241  -11.4568
            11  C1y C     9.3850  -11.4568
            12  C1z C     9.3850  -10.0938
            13  C1x C     8.2045   -9.4123
            14  C1y C     7.0241  -10.0938
            15  C1x C    11.7457  -11.4568
            16  C1x C    11.7457  -10.0938
            17  C1z C    10.5654   -9.4123
            18  O5x O     2.3025  -14.1829
            19  C1a C     5.8437  -10.7753
            20  O1a O     5.8457   -9.4135
            21  C1a C     9.3850   -8.7308
            22  C5a C    10.5654   -7.6348
            23  O1a O    11.7457   -8.7308
            24  C1b C    11.7497   -6.9511
            25  O5a O     9.3889   -6.9555
            26  O2b O    12.9156   -7.6243
            27  P1b P    14.1511   -6.9106
            28  O1c O    15.3635   -6.2106 #-
            29  O1c O    13.4565   -5.7082 #-
            30  O1c O    14.8569   -8.1325
            31  Z   Na   11.1300   -5.6700 #+
            32  Z   Na   17.5700   -6.0200 #+
BOND        33
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   12  17 1
            21    2  18 2
            22    5  19 1 #Up
            23   14  20 1 #Up
            24   12  21 1 #Up
            25   17  22 1 #Up
            26   17  23 1 #Down
            27   22  24 1
            28   22  25 2
            29   24  26 1
            30   26  27 1
            31   27  28 1
            32   27  29 1
            33   27  30 2