Entry

D00998                      Drug

Name

Neostigmine methylsulfate (JP18/USP);
Bloxiverz (TN);
Prostigmin (TN)

Product

BLOXIVERZ (Avadel Legacy Pharmaceuticals), BLOXIVERZ (Avadel Legacy Pharmaceuticals), BLOXIVERZ (Exela Pharma Sciences), BLOXIVERZ (Exela Pharma Sciences), BLOXIVERZ (Exela Pharma Sciences), NEOSTIGMINE METHYLSULFATE (Fresenius Kabi USA), NEOSTIGMINE METHYLSULFATE (Fresenius Kabi USA), NEOSTIGMINE METHYLSULFATE (Fresenius Kabi USA)

Generic

NEOSTIGMINE (Dr.Reddy's Laboratories), NEOSTIGMINE (Medical Purchasing Solutions), NEOSTIGMINE METHYLSULFATE (A-S Medication Solutions), NEOSTIGMINE METHYLSULFATE (A-S Medication Solutions), NEOSTIGMINE METHYLSULFATE (Amneal Pharmaceuticals LLC), NEOSTIGMINE METHYLSULFATE (Amphastar Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (BE Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (Camber Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (Caplin Steriles Limited), NEOSTIGMINE METHYLSULFATE (Civica), NEOSTIGMINE METHYLSULFATE (Civica), NEOSTIGMINE METHYLSULFATE (Dr.Reddys Laboratories), NEOSTIGMINE METHYLSULFATE (General Injectables and Vaccines), NEOSTIGMINE METHYLSULFATE (Gland Pharma Limited), NEOSTIGMINE METHYLSULFATE (HF Acquisition Co LLC), NEOSTIGMINE METHYLSULFATE (Henry Schein), NEOSTIGMINE METHYLSULFATE (Hikma Pharmaceuticals USA), NEOSTIGMINE METHYLSULFATE (Hikma Pharmaceuticals USA), NEOSTIGMINE METHYLSULFATE (Indoco Remedies Limited), NEOSTIGMINE METHYLSULFATE (Medical Purchasing Solutions), NEOSTIGMINE METHYLSULFATE (Medical Purchasing Solutions), NEOSTIGMINE METHYLSULFATE (Meitheal Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (Par Pharmaceutical), NEOSTIGMINE METHYLSULFATE (Sagent Pharmaceuticals), NEOSTIGMINE METHYLSULFATE (Somerset Therapeutics), NEOSTIGMINE METHYLSULFATE (Xellia Pharmaceuticals USA LLC), NEOSTIGMINE METHYLSULFATE (Xiromed LLC)

Formula

C12H19N2O2. CH3SO4

Exact mass

334.1199

Mol weight

334.3886

Structure

Simcomp

Class

Neuropsychiatric agent
DG01595  Cholinesterase inhibitor
  DG01593  Acetylcholinesterase inhibitor
DG01719  Parasympathomimetic agent

Remark

Same as:

C08200

Therapeutic category:

1233

ATC code:

N07AA01 S01EB06

Chemical structure group:

DG00987

Product (DG00987):

D00995<JP> D00998<JP/US>

Product (mixture):

D04114<JP> D09186<JP>

Efficacy

Parasympathomimetic, Acetylcholinesterase inhibitor

Comment

Physostigmine derivative

Target

ACHE [HSA:43] [KO:K01049]

Pathway

hsa00564

Glycerophospholipid metabolism

hsa04725

Cholinergic synapse

Interaction

Structure map

map07220

Cholinergic and anticholinergic drugs

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AA Anticholinesterases
     N07AA01 Neostigmine
      D00998  Neostigmine methylsulfate (JP18/USP) <JP/US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB06 Neostigmine
      D00998  Neostigmine methylsulfate (JP18/USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   123  Autonomic nervous system agents
    1233  Neostigmines
     D00998  Neostigmine methylsulfate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for ophthalmologic use
  62 General eye drops
   D00998  Neostigmine methylsulfate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Third-class OTC drugs
  Inorganic and organic chemicals
   Neostigmine
    D00998  Neostigmine methylsulfate (JP18/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00987  Neostigmine
     D00998  Neostigmine methylsulfate
  DG01719  Parasympathomimetic agent
   DG00987  Neostigmine
    D00998  Neostigmine methylsulfate
Target-based classification of drugs [BR:br08310]
Enzymes
  Hydrolases (EC3)
   Carboxylic-ester hydrolases
    ACHE
     D00998  Neostigmine methylsulfate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00998  Neostigmine methylsulfate
  D00998  Neostigmine methylsulfate injection
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01595  Cholinesterase inhibitor
   DG01593  Acetylcholinesterase inhibitor
    DG00987  Neostigmine
  DG01719  Parasympathomimetic agent
   DG00987  Neostigmine

Other DBs

CAS:

51-60-5

PubChem:

7848061

ChEBI:

7516

LigandBox:

D00998

NIKKAJI:

J262.808B

KCF data

ATOM        22
            1   C8y C    21.6932  -17.0217
            2   C8x C    22.9128  -16.3157
            3   C8x C    21.6932  -18.4279
            4   O7a O    20.4737  -16.3214
            5   C8y C    24.1207  -17.0217
            6   C8x C    22.9128  -19.1281
            7   C7a C    19.2600  -17.0274
            8   C8x C    24.1207  -18.4221
            9   N1d N    25.3402  -16.3157 #+
            10  N1c N    18.0405  -16.3274
            11  O6a O    19.2600  -18.4338
            12  C1a C    26.7988  -15.3937
            13  C1a C    24.6750  -15.2537
            14  C1a C    26.1630  -17.5234
            15  C1a C    16.8326  -17.0334
            16  C1a C    18.0405  -14.9210
            17  S4a S    32.7856  -17.4302
            18  O2a O    31.4201  -17.4243
            19  O1d O    32.7739  -18.7022
            20  O1d O    32.7272  -15.8138
            21  O1d O    34.1686  -17.4302 #-
            22  C1a C    30.6791  -16.3389
BOND        21
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     5   9 1
            9     7  10 1
            10    7  11 2
            11    9  12 1
            12    9  13 1
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16    6   8 1
            17   17  18 1
            18   17  19 2
            19   17  20 2
            20   17  21 1
            21   18  22 1