Entry |
|
Name |
Acetylcholine chloride (JP18/USP/INN); Miochol (TN) |
Product |
MIOCHOL E (Bausch & Lomb Incorporated) |
Formula |
C7H16NO2. Cl
|
Exact mass |
181.087
|
Mol weight |
181.6604
|
Structure |
|
Simcomp |
|
Class |
Cardiovascular agent
DG01532 Nicotinic cholinergic receptor agonist
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
Metabolizing enzyme substrate
DG02974 ACHE substrate
|
Remark |
Therapeutic category: | 1232 7222 |
Chemical structure group: | DG01133 |
Product (DG01133): | D00999<JP/US> |
|
Efficacy |
Miotic, Vasodilator (peripheral), Cholinergic receptor agonist |
Comment |
Quaternary ammonium compound
|
Target |
CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133] CHRN [HSA:1134 1135 1136 1137 1138 8973 1139 55584 57053 1140 1141 1142 1143 1144 1145 1146] [KO:K04803 K04804 K04805 K04806 K04807 K04808 K04809 K04810 K04811 K04812 K04813 K04814 K04815 K04816 K04817 K04818] |
Pathway |
hsa04020 | Calcium signaling pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
hsa04725 | Cholinergic synapse |
hsa04970 | Salivary secretion |
hsa04971 | Gastric acid secretion |
|
Metabolism |
Enzyme: ACHE [HSA:43]
|
Interaction |
|
Structure map |
map07220 | Cholinergic and anticholinergic drugs |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EB Parasympathomimetics
S01EB09 Acetylcholine
D00999 Acetylcholine chloride (JP18/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
12 Agents affecting peripheral nervous system
123 Autonomic nervous system agents
1232 Acetylcholines
D00999 Acetylcholine chloride (JP18/USP/INN)
7 Agents not mainly for therapeutic purpose
72 Intracorporeal diagnostic agents
722 Various function testing reagents
7222 Diagnostic reagents for circulatory function
D00999 Acetylcholine chloride (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01532 Nicotinic cholinergic receptor agonist
DG01133 Acetylcholine
D00999 Acetylcholine chloride
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG01133 Acetylcholine
D00999 Acetylcholine chloride
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01133 Acetylcholine
D00999 Acetylcholine chloride
Metabolizing enzyme substrate
DG02974 ACHE substrate
DG01133 Acetylcholine
D00999 Acetylcholine chloride
Drug classes [BR:br08332]
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
D00999 Acetylcholine chloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM
D00999 Acetylcholine chloride (JP18/USP/INN) <JP/US>
Ion channels
Ligand-gated ion channels
Acetylcholine (nicotinic)
CHRN
D00999 Acetylcholine chloride (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00999 Acetylcholine chloride for injection
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00999
Drug groups [BR:br08330]
Cardiovascular agent
DG01532 Nicotinic cholinergic receptor agonist
DG01133 Acetylcholine
Neuropsychiatric agent
DG01490 Muscarinic cholinergic receptor agonist
DG01133 Acetylcholine
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01133 Acetylcholine
Metabolizing enzyme substrate
DG02974 ACHE substrate
DG01133 Acetylcholine
|
Other DBs |
|
KCF data |
ATOM 11
1 N1d N 17.4483 -17.4183 #+
2 C1b C 18.5738 -18.0657
3 C1a C 16.6728 -15.9663
4 C1a C 15.9437 -17.4126
5 C1a C 16.6728 -18.8646
6 C1b C 19.7051 -17.4183
7 O7a O 20.8363 -18.0657
8 C7a C 21.9677 -17.4183
9 C1a C 23.0874 -18.0657
10 O6a O 21.9677 -16.1121
11 X Cl 26.5628 -17.6982 #-
BOND 9
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1
5 2 6 1
6 6 7 1
7 7 8 1
8 8 9 1
9 8 10 2
|