Apraclonidine hydrochloride

Entry

D01008                      Drug

Name

Apraclonidine hydrochloride (JAN/USP);
Iopidine (TN)

Product

IOPIDINE (Alcon Laboratories)

Generic

APRACLONIDINE (Sandoz), APRACLONIDINE OPHTHALMIC (Akorn)

Formula

C9H10Cl2N4. HCl

Exact mass

280.0049

Mol weight

281.5694

Structure

Simcomp

Class

Cardiovascular agent
DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01449  alpha2-Adrenergic receptor agonist
Ophthalmic agent
DG03201  Intraocular pressure lowering agent

Remark

Therapeutic category:

1319

ATC code:

S01EA03

Chemical structure group:

DG01130

Product (DG01130):

D01008<JP/US>

Efficacy

Antihypertensive (intraocular), alpha2-Adrenergic receptor agonist

Target

ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Interaction

Structure map

map07054

Antiglaucoma agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA03 Apraclonidine
      D01008  Apraclonidine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Alpha-adrenergic Agonists, Ophthalmic
    Apraclonidine
     D01008  Apraclonidine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01008  Apraclonidine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG01130  Apraclonidine
      D01008  Apraclonidine hydrochloride
Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG01130  Apraclonidine
    D01008  Apraclonidine hydrochloride
Drug classes [BR:br08332]
Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D01008  Apraclonidine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA2
     D01008  Apraclonidine hydrochloride (JAN/USP) <JP/US>
Drug groups [BR:br08330]
Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01450  alpha-Adrenergic receptor agonist
    DG01449  alpha2-Adrenergic receptor agonist
     DG01130  Apraclonidine
Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG01130  Apraclonidine

Other DBs

CAS:	73218-79-8

PubChem:

7848071

ChEBI:

2789

LigandBox:

D01008

NIKKAJI:

J327.542F

KCF data

ATOM        16
            1   X   Cl   21.4656  -17.6574
            2   C8x C    12.8100  -16.9400
            3   C8y C    12.8100  -18.3400
            4   C8x C    14.0000  -19.0400
            5   C8y C    15.2600  -18.3400
            6   C8y C    15.2600  -16.9400
            7   C8y C    14.0000  -16.2400
            8   X   Cl   16.4500  -19.0400
            9   N2x N    17.6400  -18.3400
            10  C2y C    17.6400  -16.9400
            11  N1b N    16.4500  -16.2400
            12  C1x C    18.9700  -18.7600
            13  C1x C    19.8100  -17.6400
            14  N1x N    18.9700  -16.5200
            15  X   Cl   14.0000  -14.8400
            16  N1a N    11.5947  -19.0351
BOND        16
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     5   8 1
            8     9  10 2
            9    10  11 1
            10    6  11 1
            11    9  12 1
            12   12  13 1
            13   13  14 1
            14   10  14 1
            15    7  15 1
            16    3  16 1