Dipivefrin hydrochloride


Entry
D01017                      Drug                                   
Name
Dipivefrin hydrochloride (USP);
Dipivefrine hydrochloride (JAN);
Propine (TN)
Formula
C19H29NO5. HCl
Exact mass
387.1813
Mol weight
387.8982
Structure
Simcomp
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Remark
Therapeutic category: 1311
ATC code: S01EA02
Chemical structure group: DG01129
Product (DG01129): D01017<JP>
Efficacy
Antiglaucoma, Adrenergic receptor agonist
Comment
Active form of prodrug: Adrenaline (Epinephrine) [DR:D00095]
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
Interaction
Structure map
map07054  Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA02 Dipivefrine
      D01017  Dipivefrin hydrochloride (USP) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1311  Mydriatic agents
     D01017  Dipivefrin hydrochloride (USP); Dipivefrine hydrochloride (JAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01129  Dipivefrine
    D01017  Dipivefrin hydrochloride
  DG01951  Catecholamine adrenergic receptor agonist
   DG01129  Dipivefrine
    D01017  Dipivefrin hydrochloride
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG01129  Dipivefrine
    D01017  Dipivefrin hydrochloride
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D01017  Dipivefrin hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D01017  Dipivefrin hydrochloride (USP) <JP>
    ADRA2
     D01017  Dipivefrin hydrochloride (USP) <JP>
    ADRB
     D01017  Dipivefrin hydrochloride (USP) <JP>
Prodrugs [br08324.html]
 D01017
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01129  Dipivefrine
  DG01951  Catecholamine adrenergic receptor agonist
   DG01129  Dipivefrine
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG01129  Dipivefrine
Prodrugs [br08324.html]
 DG01129
Other DBs
CAS: 64019-93-8
PubChem: 7848080
ChEBI: 4647
LigandBox: D01017
NIKKAJI: J349.610D
KCF data

ATOM        26
            1   X   Cl   21.9800  -26.1800
            2   C8y C    15.1900  -20.7900
            3   C8y C    15.1900  -22.1900
            4   C8x C    16.3800  -22.8900
            5   C8x C    17.6400  -22.1900
            6   C8y C    17.6400  -20.7900
            7   C8x C    16.3800  -20.0900
            8   O7a O    14.0000  -20.0900
            9   O7a O    14.0000  -22.8900
            10  C1c C    18.8300  -20.0900
            11  C1b C    20.0200  -20.7900
            12  O1a O    18.8300  -18.6900
            13  N1b N    21.2381  -20.0999
            14  C1a C    22.4195  -20.7950
            15  C7a C    14.0114  -18.6900
            16  C7a C    14.0000  -24.2900
            17  C1d C    12.7876  -24.9900
            18  O6a O    15.2124  -24.9900
            19  O6a O    15.2208  -18.0048
            20  C1d C    12.7962  -17.9752
            21  C1a C    11.5824  -18.6630
            22  C1a C    12.8076  -16.5900
            23  C1a C    11.6062  -17.2753
            24  C1a C    11.5921  -24.2996
            25  C1a C    12.7875  -26.3898
            26  C1a C    11.5920  -25.6803
BOND        25
            1     2   3 2
            2     3   4 1
            3     4   5 2
            4     5   6 1
            5     6   7 2
            6     2   7 1
            7     2   8 1
            8     3   9 1
            9     6  10 1
            10   10  11 1
            11   10  12 1
            12   11  13 1
            13   13  14 1
            14    8  15 1
            15    9  16 1
            16   16  17 1
            17   16  18 2
            18   15  19 2
            19   15  20 1
            20   20  21 1
            21   20  22 1
            22   20  23 1
            23   17  24 1
            24   17  25 1
            25   17  26 1