Noscapine


Entry
D01036                      Drug                                   
Name
Noscapine (JP18/USP/INN);
Noscapine (TN)
Formula
C22H23NO7
Exact mass
413.1475
Mol weight
413.4205
Structure
Simcomp
Source
Papaver somniferum [TAX:3469]
Remark
Same as: C09592
ATC code: R05DA07
Chemical structure group: DG01077
Product (mixture): D04296<JP>
Efficacy
Antitussive
Comment
Isoquinoline Alkaloids: Phthalideisoquinoline
Opium alkaloid derivative, non-narcotic
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R05 COUGH AND COLD PREPARATIONS
   R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
    R05DA Opium alkaloids and derivatives
     R05DA07 Noscapine
      D01036  Noscapine (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for respiratory organs
  26 Antitussives and expectorants
   D01036  Noscapine (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Third-class OTC drugs
  Inorganic and organic chemicals
   Noscapine
    D01036  Noscapine (JP18/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01036  Noscapine
Other DBs
CAS: 128-62-1
PubChem: 7848099
ChEBI: 73237
PDB-CCD: 08N[PDBj]
LigandBox: D01036
NIKKAJI: J9.283E
KCF data

ATOM        30
            1   C1y C    26.8283  -16.1596
            2   C8y C    25.8983  -17.2080
            3   C1y C    26.7758  -14.7697
            4   O7x O    28.1172  -16.7179
            5   C8y C    26.6059  -18.4199
            6   C8x C    24.5020  -17.2133
            7   C8y C    25.5646  -14.0593
            8   N1y N    27.9930  -14.0709
            9   C7x C    27.9765  -18.1191
            10  C8y C    25.9243  -19.6962
            11  C8x C    23.8113  -18.4381
            12  C8y C    25.5704  -12.6616
            13  C8y C    24.3649  -14.7638
            14  C1x C    27.9987  -12.6675
            15  C1a C    29.1984  -14.7697
            16  C8y C    24.5211  -19.6422
            17  O2a O    26.6282  -20.8202
            18  C8x C    24.3649  -11.9628
            19  C1x C    26.7875  -11.9687
            20  C8y C    23.1537  -14.0593
            21  O2a O    23.8293  -20.8541
            22  C1a C    25.9344  -22.0403
            23  C8y C    23.1537  -12.6559
            24  O2x O    21.8144  -14.4903
            25  O2x O    21.8201  -12.2190
            26  C1x C    20.9933  -13.3547
            27  C1a C    24.5322  -22.0572
            28  O6a O    29.0171  -19.0456
            29  O2a O    24.3678  -16.1571
            30  C1a C    23.1627  -16.8562
BOND        34
            1     2   5 2
            2     2   6 1
            3     3   7 1
            4     3   8 1
            5     4   9 1
            6     5  10 1
            7     6  11 2
            8     7  12 2
            9     7  13 1
            10    8  14 1
            11    8  15 1
            12   10  16 2
            13   10  17 1
            14   12  18 1
            15   12  19 1
            16   13  20 2
            17   16  21 1
            18   17  22 1
            19   18  23 2
            20   20  24 1
            21   23  25 1
            22   24  26 1
            23    5   9 1
            24   11  16 1
            25   14  19 1
            26   20  23 1
            27   25  26 1
            28   21  27 1
            29    1   2 1
            30    9  28 2
            31    1   3 1
            32   13  29 1
            33    1   4 1
            34   29  30 1