Entry

D01073                      Drug

Name

Clindamycin phosphate (JP18/USP);
Cleocin (TN);
Dalacin-S (TN);
Evoclin (TN)

Product

CLINDAGEL (Bausch Health US), CLINDAMYCIN PHOSPHATE (ALMAJECT), CLINDAMYCIN PHOSPHATE (Baxter Healthcare Corporation), XACIATO (Daré Bioscience), CLEOCIN PHOSPHATE (General Injectables & Vaccines), CLEOCIN PHOSPHATE (Henry Schein), CLEOCIN PHOSPHATE (Medical Purchasing Solutions), CLINDAMYCIN PHOSPHATE (Medical Purchasing Solutions), CLINDAMYCIN PHOSPHATE (Medical Purchasing Solutions), CLINDAMYCIN PHOSPHATE (Medical Purchasing Solutions), CLEOCIN PHOSPHATE (Medical Purchasing Solutions), CLEOCIN PHOSPHATE (Medical Purchasing Solutions), CLINDAMYCIN PHOSPHATE (Medical Purchasing Solutions), EVOCLIN (Mylan Pharmaceuticals), CLINDESSE (Padagis Israel Pharmaceuticals), CLEOCIN PHOSPHATE (Pharmacia & Upjohn Company LLC), CLEOCIN (Pharmacia & Upjohn Company LLC), CLEOCIN T (Pharmacia & Upjohn Company LLC), CLEOCIN PHOSPHATE (Pharmacia & Upjohn Company LLC), CLEOCIN PHOSPHATE (Pharmacia & Upjohn Company LLC), CLEOCIN (Pharmacia & Upjohn Company LLC)

Generic

CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Mylan Institutional LLC), CLINDAMYCIN IN 5 PERCENT DEXTROSE (Civica), CLINDAMYCIN IN 5 PERCENT DEXTROSE (Sandoz), CLINDAMYCIN IN 5 PERCENT DEXTROSE (Sandoz), CLINDAMYCIN PHOSPHATE (A-S Medication Solutions), CLINDAMYCIN PHOSPHATE (A-S Medication Solutions), CLINDAMYCIN PHOSPHATE (A-S Medication Solutions), CLINDAMYCIN PHOSPHATE (A-S Medication Solutions), CLINDAMYCIN PHOSPHATE (A-S Medication Solutions), CLINDAMYCIN (Akorn), CLINDAMYCIN PHOSPHATE (Amneal Pharmaceuticals NY LLC), CLINDAMYCIN PHOSPHATE (Baxter Healthcare Corporation), CLINDAMYCIN PHOSPHATE (Baxter Healthcare Corporation), CLINDAMYCIN PHOSPHATE (Baxter Healthcare Corporation), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Bryant Ranch Prepack), CLINDAMYCIN PHOSPHATE (Cadila Healthcare Limited), CLINDAMYCIN PHOSPHATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), CLINDAMYCIN PHOSPHATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Encube Ethicals Private Limited), CLINDAMYCIN (Fresenius Kabi USA), CLINDAMYCIN (Fresenius Kabi USA), CLINDAMYCIN PHOSPHATE (GLENMARK PHARMACEUTICALS), CLINDAMYCIN (General Injectables and Vaccines), CLINDAMYCIN PHOSPHATE (Glasshouse Pharmaceuticals Limited Canada), CLINDAMYCIN PHOSPHATE (Greenstone LLC), CLINDAMYCIN PHOSPHATE (Greenstone LLC), CLINDAMYCIN (Henry Schein), CLINDAMYCIN PHOSPHATE (Marlex Pharmaceuticals), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN (Medical Purchasing Solutions), CLINDAMYCIN PHOSPHATE (Medimetriks Pharmaceuticals), CLINDACIN ETZ (Medimetriks Pharmaceuticals), CLINDAMYCIN PHOSPHATE (NORTHSTAR RX LLC), CLINDAMYCIN PHOSPHATE (NORTHSTAR RX LLC), CLINDAMYCIN PHOSPHATE (NuCare Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Oceanside Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Padagis Israel Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Padagis Israel Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Padagis Israel Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Padagis Israel Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Padagis Israel Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Preferred Pharmaceuticals), CLINDAMYCIN PHOSPHATE (RPK Pharmaceuticals), CLINDAMYCIN PHOSPHATE (RPK Pharmaceuticals), CLINDAMYCIN (Sagent Pharmaceuticals), CLINDAMYCIN (Sagent Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Solaris Pharma Corporation), CLINDAMYCIN PHOSPHATE (Solaris Pharma Corporation), CLINDAMYCIN PHOSPHATE (Taro Pharmaceuticals U.S.A.), CLINDAMYCIN PHOSPHATE (Taro Pharmaceuticals U.S.A.), CLINDAMYCIN PHOSPHATE (Taro Pharmaceuticals U.S.A.), CLINDAMYCIN PHOSPHATE (Taro Pharmaceuticals U.S.A.), CLINDAMYCIN PHOSPHATE (Teligent Pharma), CLINDAMYCIN PHOSPHATE (Viona Pharmaceuticals), CLINDAMYCIN PHOSPHATE (Encube Ethicals Private Limited), CLINDAMYCIN PHOAPHATE TOPICAL SOLUTION USP, 1% (Encube Ethicals Private Limited), CLINDAMYCIN PHOAPHATE TOPICAL SOLUTION, 1% (Preferred Pharmaceuticals), CLINDAMYCIN PHOSPHATE (A-S Medication Solutions), CLINDAVIX (Primary Pharmaceuticals), NUCARACLINPAK (NuCare Pharmaceuticals)

Formula

C18H34ClN2O8PS

Exact mass

504.1462

Mol weight

504.9629

Structure

Simcomp

Class

Antibacterial
DG01578 Lincosamide antibiotic

Remark

Same as:

C11728

Therapeutic category:

2634 6112

ATC code:

D10AF01 G01AA10 J01FF01

Chemical structure group:

DG00435

Product (DG00435):

D01073<JP/US> D01990<US> D02132<JP/US>

Product (mixture):

D10602<JP/US> D11084<US>

Efficacy

Antibacterial, Protein biosynthesis inhibitor

Disease

Infections due to susceptible strains of Streptococci [DS:H00333]
Acne vulgaris [DS:H01445]

Comment

Semisynthetic lincosamide
Active form of prodrug: Clindamycin [DR:D00277]

Target

50S ribosomal subunit

Pathway

ko03010

Ribosome

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF01 Clindamycin
      D01073  Clindamycin phosphate (JP18/USP) <JP/US>
G GENITO URINARY SYSTEM AND SEX HORMONES
  G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
   G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
    G01AA Antibiotics
     G01AA10 Clindamycin
      D01073  Clindamycin phosphate (JP18/USP) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FF Lincosamides
     J01FF01 Clindamycin
      D01073  Clindamycin phosphate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
  Antibacterials, Other
   Clindamycin
    D01073  Clindamycin phosphate (JP18/USP)
Dermatological Agents
  Topical Anti-infectives
   Antibacterials, dermatological
    Clindamycin
     D01073  Clindamycin phosphate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  26  Epidermides
   263  Suppurative dermatosis agents
    2634  Antibiotics for external use
     D01073  Clindamycin phosphate (JP18/USP)
6  Agents against pathologic organisms and parasites
  61  Antibiotics
   611  Acting mainly on gram-positive bacteria
    6112  Lincomycins
     D01073  Clindamycin phosphate (JP18/USP)
Drug groups [BR:br08330]
Antibacterial
  DG01578  Lincosamide antibiotic
   DG00435  Clindamycin
    D01073  Clindamycin phosphate
Drug classes [BR:br08332]
Antibacterial
  DG01578  Lincosamide antibiotic
   D01073  Clindamycin phosphate
Antimicrobials [BR:br08307]
Antibacterials
  Protein biosynthesis inhibitor
   Lincosamide
    D01073  Clindamycin phosphate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D01073  Clindamycin phosphate
  D01073  Clindamycin phosphate injection
Prodrugs [br08324.html]
D01073
Drug groups [BR:br08330]
Antibacterial
  DG01578  Lincosamide antibiotic
   DG00435  Clindamycin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
  Protein biosynthesis inhibitor
   Lincosamide
    DG00435  Clindamycin
Prodrugs [br08324.html]
DG00435

Other DBs

CAS:	24729-96-2

PubChem:

7848136

ChEBI:

3746

LigandBox:

D01073

NIKKAJI:

J286.383I

KCF data

ATOM        31
            1   C1y C    20.3420  -15.6751
            2   C1y C    20.3420  -17.0766
            3   C1y C    21.5567  -17.7773
            4   C1y C    22.7713  -17.0766
            5   C1y C    22.7713  -15.6751
            6   O2x O    21.5567  -14.9744
            7   S2a S    23.9859  -14.9744
            8   C1a C    23.9859  -13.5730
            9   O2b O    23.9859  -17.7773
            10  O1a O    21.5567  -19.1789
            11  O1a O    19.1275  -17.7773
            12  C1c C    19.1275  -14.9744
            13  N1b N    17.9129  -15.6751
            14  C1c C    19.1275  -13.5730
            15  X   Cl   17.9129  -12.8722
            16  C1a C    20.3420  -12.8722
            17  C5a C    16.6983  -14.9744
            18  C1y C    15.4837  -15.6751
            19  O5a O    16.6983  -13.5730
            20  N1y N    14.3578  -14.8803
            21  C1x C    13.2387  -15.7030
            22  C1y C    13.6855  -17.0322
            23  C1x C    15.0690  -17.0253
            24  C1a C    14.3578  -13.4808
            25  C1b C    12.9918  -18.2479
            26  C1b C    11.6141  -18.2550
            27  C1a C    10.9162  -19.4785
            28  P1b P    25.2093  -17.0704
            29  O1c O    26.4215  -16.3706
            30  O1c O    24.5068  -15.8540
            31  O1c O    25.9066  -18.2777
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     5   7 1 #Down
            8     7   8 1
            9     4   9 1 #Down
            10    3  10 1 #Up
            11    2  11 1 #Up
            12    1  12 1
            13   12  13 1
            14   12  14 1
            15   14  15 1 #Up
            16   14  16 1
            17   13  17 1
            18   18  17 1 #Down
            19   17  19 2
            20   18  20 1
            21   20  21 1
            22   21  22 1
            23   22  23 1
            24   18  23 1
            25   20  24 1
            26   22  25 1 #Up
            27   25  26 1
            28   26  27 1
            29    9  28 1
            30   28  29 1
            31   28  30 2
            32   28  31 1