Pemirolast potassium


Entry
D01088                      Drug                                   
Name
Pemirolast potassium (JP18/USAN);
Alamast (TN);
Alegysal (TN);
Pemilaston (TN)
Formula
C10H7N6O. K
Exact mass
266.0318
Mol weight
266.3005
Structure
Simcomp
Class
Anti-allergic agent
 DG01805  Mediator release inhibitor
Remark
Therapeutic category: 1319 4490
Chemical structure group: DG02929
Product (DG02929): D01088<JP>
Efficacy
Antiallergic, Mediator release inhibitor
Comment
Inhibition of phospholipase C, phospholipase A2, phosphodiesterase
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01088  Pemirolast potassium (JP18/USAN)
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D01088  Pemirolast potassium (JP18/USAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for ophthalmologic use
  64 Allergy eye drops
   D01088  Pemirolast potassium (JP18/USAN)
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D01088  Pemirolast potassium (JP18/USAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Pemirolast potassium
    D01088  Pemirolast potassium (JP18/USAN)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01805  Mediator release inhibitor
   DG02929  Pemirolast
    D01088  Pemirolast potassium
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01088  Pemirolast potassium
  D01088  Pemirolast potassium tablets
  D01088  Pemirolast potassium for syrup
  D01088  Pemirolast potassium ophthalmic solution
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01088
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01088
Rx-to-OTC switch list in Japan [br08314.html]
 D01088
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01805  Mediator release inhibitor
   DG02929  Pemirolast
Other DBs
CAS: 100299-08-9
PubChem: 7848151
ChEBI: 31971
LigandBox: D01088
NIKKAJI: J153.945K
KCF data

ATOM        18
            1   N5x N    35.8197  -19.8785
            2   N5x N    36.2555  -18.5480
            3   N4x N    35.1198  -17.7219 #-
            4   C8y C    33.9842  -18.5480
            5   N5x N    34.4198  -19.8785
            6   C8y C    32.7748  -17.8427
            7   C8x C    27.9327  -16.4325
            8   C8x C    27.9327  -17.8324
            9   C8x C    29.1480  -18.5323
            10  C8y C    29.1480  -15.7325
            11  C8y C    30.3561  -16.4325
            12  N4y N    30.3502  -17.8324
            13  C8y C    31.5595  -18.5376
            14  C8x C    32.7808  -16.4428
            15  N5x N    31.5714  -15.7378
            16  O5x O    31.5536  -19.9375
            17  C1a C    29.1497  -14.3326
            18  Z   K    35.0700  -16.0300 #+
BOND        19
            1     9  12 1
            2    11  10 1
            3    10   7 2
            4     5   1 1
            5     1   2 2
            6     2   3 1
            7     3   4 1
            8    11  12 1
            9    12  13 1
            10   13   6 1
            11    6  14 2
            12   14  15 1
            13   15  11 2
            14    6   4 1
            15    4   5 2
            16    7   8 1
            17   13  16 2
            18    8   9 2
            19   10  17 1