Nateglinide

Entry

D01111                      Drug

Name

Nateglinide (JP18/USP/INN);
Starsis (TN)

Product

Generic

NATEGLINIDE (Actavis Pharma), NATEGLINIDE (American Health Packaging), NATEGLINIDE (American Health Packaging), NATEGLINIDE (AvKARE), NATEGLINIDE (Cadila Healthcare Limited), NATEGLINIDE (Cadila Pharmaceuticals Limited), NATEGLINIDE (Dr. Reddy's Laboratories Limited), NATEGLINIDE (Golden State Medical Supply), NATEGLINIDE (Modavar Pharmaceuticals LLC), NATEGLINIDE (Nivagen Pharmaceuticals), NATEGLINIDE (Rising Pharma Holdings), NATEGLINIDE (Strides Pharma Science Limited), NATEGLINIDE (Zydus Pharmaceuticals (USA))

Formula

C19H27NO3

Exact mass

317.1991

Mol weight

317.4226

Structure

Simcomp

Class

Antidiabetic agent
DG01508  Sulfonylurea receptor agonist
  DG01735  Glinide
DG02044  Hypoglycemic agent
  DG01735  Glinide
Metabolizing enzyme substrate
DG01642  CYP2C9 substrate

Remark

Same as:

C12508

Therapeutic category:

3969

ATC code:

A10BX03

Product:

D01111<JP/US>

Efficacy

Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist

Disease

Type 2 diabetes mellitus [DS:H00409]

Comment

Glinide derivative
Treatment of Type II diabetes mellitus

Target

ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]

Pathway

hsa02010

ABC transporters

hsa04911

Insulin secretion

hsa04930

Type II diabetes mellitus

Metabolism

Enzyme: CYP2C9 [HSA:1559]

Interaction

Structure map

map07051

Antidiabetics

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BX Other blood glucose lowering drugs, excl. insulins
     A10BX03 Nateglinide
      D01111  Nateglinide (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Blood Glucose Regulators
  Antidiabetic Agents
   Glucose Control Agents, Other
    Nateglinide
     D01111  Nateglinide (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D01111  Nateglinide (JP18/USP/INN)
Drug groups [BR:br08330]
Antidiabetic agent
  DG01508  Sulfonylurea receptor agonist
   DG01735  Glinide
    D01111  Nateglinide
  DG02044  Hypoglycemic agent
   DG01735  Glinide
    D01111  Nateglinide
Metabolizing enzyme substrate
  DG01642  CYP2C9 substrate
   D01111  Nateglinide
Drug classes [BR:br08332]
Antidiabetic agent
  DG01735  Glinide
   D01111  Nateglinide
  DG02044  Hypoglycemic agent
   D01111  Nateglinide
Target-based classification of drugs [BR:br08310]
Transporters
  ABC transporters
   ABCC subfamily
    ABCC8(SUR1)/KCNJ11(KIR6.2)
     D01111  Nateglinide (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D01111  Nateglinide
  D01111  Nateglinide tablets
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D01111
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D01111
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D01111
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D01111
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D01111

Other DBs

CAS:	105816-04-4

PubChem:

7848174

ChEBI:

31897

LigandBox:

D01111

NIKKAJI:

J259.863I J263.263B

KCF data

ATOM        23
            1   C1b C    21.1279  -14.8259
            2   C1c C    21.1279  -16.2406
            3   C6a C    22.3304  -16.9480
            4   O6a O    22.3304  -18.3627
            5   O6a O    23.4622  -16.3114
            6   N1b N    19.8547  -16.9480
            7   C8y C    22.3304  -14.1186
            8   C8x C    22.3304  -12.7039
            9   C8x C    23.4622  -11.9965
            10  C8x C    24.7354  -12.7039
            11  C8x C    24.7354  -14.1186
            12  C8x C    23.5329  -14.8259
            13  C5a C    18.6522  -16.2406
            14  C1y C    17.3789  -16.8772
            15  O5a O    18.6522  -14.8259
            16  C1x C    17.3789  -18.2919
            17  C1x C    16.1764  -18.9993
            18  C1y C    14.9740  -18.2212
            19  C1x C    14.9740  -16.8772
            20  C1x C    16.1764  -16.1699
            21  C1c C    13.7715  -18.9286
            22  C1a C    12.5690  -18.2212
            23  C1a C    13.7715  -20.3433
BOND        24
            1     2   6 1
            2     2   1 1 #Down
            3     2   3 1
            4     3   4 2
            5     3   5 1
            6     1   7 1
            7     7   8 2
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 2
            12    7  12 1
            13    6  13 1
            14   14  13 1 #Down
            15   13  15 2
            16   14  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   14  20 1
            22   18  21 1 #Up
            23   21  22 1
            24   21  23 1