| Entry |
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| Name | Adapalene (JAN/USP/INN); Differin (TN) | ||||||||||
| Product | DIFFERIN (GALDERMA LABORATORIES), DIFFERIN (Galderma Laboratories), DIFFERIN (Galderma Laboratories), ADAPALENE (Perrigo New York) | ||||||||||
| Generic | ADAPALENE (A-S Medication Solutions), ADAPALENE (Actavis Pharma), ADAPALENE (Alembic Pharmaceuticals), ADAPALENE (Aleor Dermaceuticals Limited), ADAPALENE (Bryant Ranch Prepack), ADAPALENE (E. Fougera & Co. a division of Fougera Pharmaceuticals), ADAPALENE (Glenmark Pharmaceuticals), ADAPALENE (Mayne Pharma), ADAPALENE (Prasco Laboratories), ADAPALENE (PruGen), ADAPALENE (Sandoz), ADAPALENE (Taro Pharmaceuticals U.S.A.), ADAPALENE TOPICAL SOLUTION (CALL INC (d.b.a Rochester Pharmaceuticals)) | ||||||||||
| Formula | C28H28O3 | ||||||||||
| Exact mass | 412.2038 | ||||||||||
| Mol weight | 412.5201 | ||||||||||
| Structure |  | ||||||||||
| Class | Vitamin and mineral DG01604 Retinol derivative | ||||||||||
| Remark |
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| Efficacy | Anti-acne, Retinoic acid receptor (RAR) agonist | ||||||||||
| Disease | Acne vulgaris [DS:H01445] | ||||||||||
| Target | NR1B3 (RARG) [HSA:5916] [KO:K08529] NR1B2 (RARB) [HSA:5915] [KO:K08528] NR2B3 (RXRG) [HSA:6258] [KO:K08526] NR2B2 (RXRB) [HSA:6257] [KO:K08525] | ||||||||||
| Pathway |
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| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] D DERMATOLOGICALS D10 ANTI-ACNE PREPARATIONS D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE D10AD Retinoids for topical use in acne D10AD03 Adapalene D01112 Adapalene (JAN/USP/INN) <JP/US> USP drug classification [BR:br08302] Dermatological Agents Acne and Rosacea Agents Retinoids Adapalene D01112 Adapalene (JAN/USP/INN) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 26 Epidermides 269 Miscellaneous 2699 Others D01112 Adapalene (JAN/USP/INN) Drug groups [BR:br08330] Vitamin and mineral DG01604 Retinol derivative D01112 Adapalene Target-based classification of drugs [BR:br08310] Nuclear receptors Thyroid hormone like receptors Retinoic acid receptor (RAR) NR1B2 (RARB) D01112 Adapalene (JAN/USP/INN) <JP/US> NR1B3 (RARG) D01112 Adapalene (JAN/USP/INN) <JP/US> Hepatocyte nuclear factor 4 like receptors Retinoid X receptor (RXR) NR2B2 (RXRB) D01112 Adapalene (JAN/USP/INN) <JP/US> NR2B3 (RXRG) D01112 Adapalene (JAN/USP/INN) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D01112 Ibuprofen piconol New drug approvals in Japan [br08318.html] Drugs with new active ingredients D01112 Rx-to-OTC switch list in the USA [br08315.html] D01112 | ||||||||||
| Other DBs |
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| KCF data | ATOM 31 1 C1z C 17.7219 -19.1703 2 C1x C 16.9759 -20.6495 3 C1y C 16.9759 -21.9529 4 C1y C 16.5531 -21.1864 5 C1y C 18.8839 -21.1864 6 C1x C 15.2964 -22.4094 7 C1x C 18.1087 -23.0011 8 C1x C 16.5531 -19.8380 9 C1x C 17.7237 -21.8606 10 C1x C 18.8874 -19.8380 11 C8x C 20.0526 -13.7790 12 C8y C 20.0526 -15.1274 13 C8x C 21.2231 -15.8016 14 C8x C 21.2231 -13.1048 15 C8y C 22.3869 -13.7790 16 C8y C 22.3811 -15.1274 17 C8x C 23.5460 -15.8065 18 C8x C 24.7166 -15.1374 19 C8y C 24.7223 -13.7890 20 C8x C 23.5574 -13.1099 21 C8y C 18.8851 -15.8022 22 C8x C 17.7197 -15.1251 23 C8x C 16.5524 -15.8000 24 C8y C 16.5531 -17.1484 25 C8y C 17.7212 -17.8219 26 C8x C 18.8885 -17.1472 27 C6a C 25.8929 -13.1198 28 O6a O 27.0577 -13.7989 29 O6a O 25.8988 -11.7714 30 O2a O 15.3856 -17.8232 31 C1a C 15.3864 -19.1716 BOND 36 1 14 11 1 2 1 2 1 3 2 3 1 4 8 4 1 5 4 9 1 6 9 5 1 7 15 16 1 8 16 17 1 9 17 18 2 10 18 19 1 11 19 20 2 12 20 15 1 13 5 10 1 14 12 21 1 15 10 1 1 16 1 8 1 17 3 6 1 18 3 7 1 19 4 6 1 20 21 22 2 21 22 23 1 22 23 24 2 23 24 25 1 24 25 26 2 25 26 21 1 26 5 7 1 27 19 27 1 28 11 12 2 29 27 28 2 30 12 13 1 31 27 29 1 32 13 16 2 33 24 30 1 34 15 14 2 35 30 31 1 36 25 1 1 |