Entry |
|
Name |
Ibuprofen piconol (JP18/USAN); Staderm (TN) |
Formula |
C19H23NO2
|
Exact mass |
297.1729
|
Mol weight |
297.3914
|
Structure |
|
Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
|
Remark |
Therapeutic category: | 2649 |
ATC code: | C01EB16 G02CC01 M01AE01 M02AA13 R02AX02 |
Chemical structure group: | DG00245 |
Product (DG00245): | D00126<JP/US> D01122<JP> D06606<JP/US> |
|
Efficacy |
Analgesic, Anti-inflammatory, COX inhibitor |
Comment |
Propionic acid derivative
Active form of prodrug: Ibuprofen [DR:D00126]
|
Target |
PTGS1 (COX1) [HSA:5742] [KO:K00509] PTGS2 (COX2) [HSA:5743] [KO:K11987] |
Pathway |
hsa00590 | Arachidonic acid metabolism |
|
Metabolism |
Enzyme: CYP2C9 [HSA:1559]
|
Interaction |
|
Structure map |
map07219 | Cyclooxygenase inhibitors |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01E OTHER CARDIAC PREPARATIONS
C01EB Other cardiac preparations
C01EB16 Ibuprofen
D01122 Ibuprofen piconol (JP18/USAN) <JP>
G GENITO URINARY SYSTEM AND SEX HORMONES
G02 OTHER GYNECOLOGICALS
G02C OTHER GYNECOLOGICALS
G02CC Antiinflammatory products for vaginal administration
G02CC01 Ibuprofen
D01122 Ibuprofen piconol (JP18/USAN) <JP>
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AE Propionic acid derivatives
M01AE01 Ibuprofen
D01122 Ibuprofen piconol (JP18/USAN) <JP>
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA13 Ibuprofen
D01122 Ibuprofen piconol (JP18/USAN) <JP>
R RESPIRATORY SYSTEM
R02 THROAT PREPARATIONS
R02A THROAT PREPARATIONS
R02AX Other throat preparetions
R02AX02 Ibuprofen
D01122 Ibuprofen piconol (JP18/USAN) <JP>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Ibuprofen
D01122 Ibuprofen piconol (JP18/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2649 Others
D01122 Ibuprofen piconol (JP18/USAN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
56 Purulent skin remedies
D01122 Ibuprofen piconol (JP18/USAN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Ibuprofen piconol
D01122 Ibuprofen piconol (JP18/USAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00245 Ibuprofen
D01122 Ibuprofen piconol
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00245 Ibuprofen
D01122 Ibuprofen piconol
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D01122 Ibuprofen piconol
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D01122 Ibuprofen piconol (JP18/USAN) <JP>
PTGS2 (COX2)
D01122 Ibuprofen piconol (JP18/USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01122 Ibuprofen piconol ointment
D01122 Ibuprofen piconol cream
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01122
Prodrugs [br08324.html]
D01122
Rx-to-OTC switch list in Japan [br08314.html]
D01122
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00245 Ibuprofen
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00245 Ibuprofen
|
Other DBs |
|
KCF data |
ATOM 22
1 C8x C 30.7421 -16.2559
2 C8y C 30.7421 -17.6563
3 N5x N 31.9578 -18.3565
4 C8x C 33.1663 -17.6563
5 C8x C 33.1663 -16.2559
6 C8x C 31.9578 -15.5557
7 C1b C 29.5296 -18.3570
8 O7a O 28.3166 -17.6575
9 C7a C 27.1042 -18.3583
10 C1c C 25.8910 -17.6587
11 O6a O 27.1048 -19.7587
12 C8y C 24.6787 -18.3595
13 C8x C 23.4712 -17.6571
14 C8x C 22.2589 -18.3580
15 C8y C 22.2595 -19.7584
16 C8x C 23.4727 -20.4579
17 C8x C 24.6850 -19.7570
18 C1b C 21.0471 -20.4591
19 C1c C 19.8339 -19.7596
20 C1a C 18.6216 -20.4604
21 C1a C 19.8332 -18.3592
22 C1a C 25.8903 -16.2583
BOND 23
1 9 11 2
2 5 6 2
3 10 12 1
4 6 1 1
5 2 7 1
6 1 2 2
7 7 8 1
8 12 13 2
9 13 14 1
10 14 15 2
11 15 16 1
12 16 17 2
13 17 12 1
14 2 3 1
15 15 18 1
16 8 9 1
17 18 19 1
18 3 4 2
19 19 20 1
20 9 10 1
21 19 21 1
22 4 5 1
23 10 22 1
|