Entry

D01136                      Drug

Name

Tranexamic acid (JP18/USP/INN);
Cyklokapron (TN);
Rikavarin (TN);
Transamin (TN)

Product

LYSTEDA (Amring Pharmaceuticals), TRANEXAMIC ACID IN SODIUM CHLORIDE (Exela Pharma Sciences), LYSTEDA (Ferring Pharmaceuticals), CYKLOKAPRON (Pfizer Laboratories Div Pfizer)

Generic

TRANEXAMIC ACID (A-S Medication Solutions), TRANEXAMIC ACID (A-S Medication Solutions), TRANEXAMIC ACID (ANI Pharmaceuticals), TRANEXAMIC ACID (Actavis Pharma), TRANEXAMIC ACID (Almaject), TRANEXAMIC ACID (American Regent), TRANEXAMIC ACID (Amneal Pharmaceuticals LLC), TRANEXAMIC ACID (Amring Pharmaceuticals), TRANEXAMIC ACID (Apollo Pharmaceuticals), TRANEXAMIC ACID (Apotex Corp.), TRANEXAMIC ACID (Armas Pharmaceuticals), TRANEXAMIC ACID (Athenex Pharmaceutical Division), TRANEXAMIC ACID (AuroMedics Pharma LLC), TRANEXAMIC ACID (Baxter Healthcare Corporation), TRANEXAMIC ACID (Bryant Ranch Prepack), TRANEXAMIC ACID (Bryant Ranch Prepack), TRANEXAMIC ACID (Bryant Ranch Prepack), TRANEXAMIC ACID (Bryant Ranch Prepack), TRANEXAMIC ACID (Cadila Healthcare Limited), TRANEXAMIC ACID (Caplin Steriles Limited), TRANEXAMIC ACID (Fresenius Kabi USA), TRANEXAMIC ACID (Gland Pharma Limited), TRANEXAMIC ACID (HF Acquisition Co LLC), TRANEXAMIC ACID (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), TRANEXAMIC ACID (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), TRANEXAMIC ACID (Methapharm), TRANEXAMIC ACID (Micro Labs Limited), TRANEXAMIC ACID (Mylan Institutional LLC), TRANEXAMIC ACID (Provepharm), TRANEXAMIC ACID (XGen Pharmaceuticals DJB), TRANEXAMIC ACID (Zydus Pharmaceuticals (USA))

Formula

C8H15NO2

Exact mass

157.1103

Mol weight

157.2102

Structure

Simcomp

Class

Blood modifier agent
DG02016  Hemostatics
  DG02012  Antifibrinolytic
   DG01540  Plasmin inhibitor

Remark

Same as:

C12535

Therapeutic category:

3327 4490

ATC code:

B02AA02

Product:

D01136<JP/US>

Efficacy

Antifibrinolytic, Anti-inflammatory, Plasmin inhibitor

Disease

Hemophilia [DS:H00219]

Target

PLG [HSA:5340] [KO:K01315]

Pathway

hsa04610

Complement and coagulation cascades

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02A ANTIFIBRINOLYTICS
    B02AA Amino acids
     B02AA02 Tranexamic acid
      D01136  Tranexamic acid (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Blood Products and Modifiers
  Hemostasis Agents
   Tranexamic Acid
    D01136  Tranexamic acid (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
3  Agents affecting metabolism
  33  Blood and body fluid agents
   332  Hemostatics
    3327  Antiplasmins
     D01136  Tranexamic acid (JP18/USP/INN)
4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D01136  Tranexamic acid (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Nourishing tonics and health supplements
  38 Vitamin C based drugs
   D01136  Tranexamic acid (JP18/USP/INN)
Agents for dental and stomatological use
  73 Stomatologic and laryngologic remedies (incl. toche without claims for cough and phlegm)
   D01136  Tranexamic acid (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
First-class OTC drugs
  Inorganic and organic chemicals
   Tranexamic acid
    D01136  Tranexamic acid (JP18/USP/INN)
Third-class OTC drugs
  Inorganic and organic chemicals
   Tranexamic acid
    D01136  Tranexamic acid (JP18/USP/INN)
Drug groups [BR:br08330]
Blood modifier agent
  DG02016  Hemostatics
   DG02012  Antifibrinolytic
    DG01540  Plasmin inhibitor
     D01136  Tranexamic acid
Target-based classification of drugs [BR:br08310]
Enzymes
  Hydrolases (EC3)
   Serine peptidases
    PLG
     D01136  Tranexamic acid (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D01136  Tranexamic acid
  D01136  Tranexamic acid tablets
  D01136  Tranexamic acid capsules
  D01136  Tranexamic acid injection
Rx-to-OTC switch list in Japan [br08314.html]
D01136

Other DBs

CAS:

1197-18-8

PubChem:

7848199

ChEBI:

48669

PDB-CCD:

AMH[PDBj]

LigandBox:

D01136

NIKKAJI:

J3.664A

KCF data

ATOM        11
            1   C1x C    23.7617  -17.2548
            2   C1x C    23.7617  -18.6550
            3   C1y C    24.9772  -19.3552
            4   C1x C    26.1856  -18.6550
            5   C1x C    26.1856  -17.2548
            6   C1y C    24.9772  -16.5547
            7   C6a C    24.9789  -15.1545
            8   O6a O    26.1924  -14.4560
            9   O6a O    23.7673  -14.4529
            10  C1b C    24.9789  -20.7554
            11  N1a N    26.1924  -21.4540
BOND        11
            1     5   6 1
            2     6   1 1
            3     6   7 1
            4     1   2 1
            5     7   8 1
            6     2   3 1
            7     7   9 2
            8     3   4 1
            9     3  10 1 #Down
            10    4   5 1
            11   10  11 1