Tolterodine tartrate


Entry
D01148                      Drug                                   
Name
Tolterodine tartrate (JAN/USP);
Detrol (TN);
Detrusitol (TN)
Product
TOLTERODINE TARTRATE EXTENDED RELEASE (Greenstone LLC), DETROL (Pharmacia & Upjohn Company LLC), DETROL LA (Pharmacia and Upjohn Company LLC)
  Generic
TOLTERODINE TARTRATE (American Health Packaging), TOLTERODINE TARTRATE (Major Pharmaceuticals), TOLTERODINE TARTRATE (Torrent Pharmaceuticals Limited), TOLTERODINE TARTRATE (A-S Medication Solutions), TOLTERODINE TARTRATE (A-S Medication Solutions), TOLTERODINE TARTRATE (ANI Pharmaceuticals), TOLTERODINE TARTRATE (Ajanta Pharma USA), TOLTERODINE TARTRATE (Athem LLC), TOLTERODINE TARTRATE (Camber Pharmaceuticals), TOLTERODINE TARTRATE (Camber Pharmaceuticals), TOLTERODINE TARTRATE (Greenstone LLC), TOLTERODINE TARTRATE (Macleods Pharmaceuticals Limited), TOLTERODINE TARTRATE (Marlex Pharmaceuticals), TOLTERODINE TARTRATE (Proficient Rx LP), TOLTERODINE TARTRATE (REMEDYREPACK), TOLTERODINE TARTRATE (REMEDYREPACK), TOLTERODINE TARTRATE (Rising Pharma Holdings), TOLTERODINE TARTRATE (Slate Run Pharmaceuticals), TOLTERODINE TARTRATE (Teva Pharmaceuticals USA), TOLTERODINE TARTRATE (Teva Pharmaceuticals USA), TOLTERODINE TARTRATE (Unichem Pharmaceuticals (USA))
Formula
C22H31NO. C4H6O6
Exact mass
475.257
Mol weight
475.5745
Structure
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2590
ATC code: G04BD07
Chemical structure group: DG00480
Product (DG00480): D01148<JP/US>
Efficacy
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist
Comment
Treatment of urinary incontinence
Target
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD07 Tolterodine
      D01148  Tolterodine tartrate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Tolterodine
    D01148  Tolterodine tartrate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D01148  Tolterodine tartrate (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00480  Tolterodine
    D01148  Tolterodine tartrate
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00480  Tolterodine
    D01148  Tolterodine tartrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00480  Tolterodine
     D01148  Tolterodine tartrate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM3
     D01148  Tolterodine tartrate (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01148
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01148
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D01148
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00480  Tolterodine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00480  Tolterodine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00480  Tolterodine
Other DBs
CAS: 124937-52-6
PubChem: 7848211
ChEBI: 32245
LigandBox: D01148
NIKKAJI: J1.208.248G
KCF data

ATOM        34
            1   O6a O    22.5567  -17.4447
            2   C6a C    23.7680  -16.7435
            3   C1c C    24.9791  -17.4447
            4   C1c C    26.1905  -16.7435
            5   C6a C    27.4018  -17.4447
            6   O6a O    28.6130  -16.7435
            7   O6a O    23.7680  -15.3410
            8   O1a O    24.9791  -18.8472
            9   O1a O    26.1905  -15.3410
            10  O6a O    27.4018  -18.8472
            11  C1c C     9.8068  -16.8754
            12  N1c N    11.0205  -17.5762
            13  C1b C    12.2344  -16.8754
            14  C1b C    13.4481  -17.5762
            15  C1c C    14.6618  -16.8754
            16  C8y C    15.8756  -17.5762
            17  C8x C    17.0894  -16.8754
            18  C8y C    18.3032  -17.5762
            19  C1a C    19.5170  -16.8754
            20  C1a C     8.5930  -17.5762
            21  C1a C     9.8068  -15.4739
            22  C1c C    11.0205  -18.9775
            23  C1a C     9.7899  -19.6882
            24  C1a C    12.2175  -19.6687
            25  C8y C    14.6618  -15.4740
            26  C8y C    15.8756  -18.9774
            27  C8x C    18.3032  -18.9776
            28  C8x C    17.1102  -19.6905
            29  O1a O    14.6827  -19.6663
            30  C8x C    15.8607  -14.7817
            31  C8x C    15.8606  -13.3802
            32  C8x C    14.6468  -12.6795
            33  C8x C    13.4479  -13.3718
            34  C8x C    13.4480  -14.7733
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     2   7 2
            7     3   8 1 #Up
            8     4   9 1 #Up
            9     5  10 2
            10   11  12 1
            11   12  13 1
            12   13  14 1
            13   15  14 1 #Down
            14   15  16 1
            15   16  17 1
            16   17  18 2
            17   18  19 1
            18   11  20 1
            19   11  21 1
            20   12  22 1
            21   22  23 1
            22   22  24 1
            23   15  25 1
            24   16  26 2
            25   18  27 1
            26   26  28 1
            27   28  27 2
            28   26  29 1
            29   25  30 2
            30   30  31 1
            31   31  32 2
            32   32  33 1
            33   33  34 2
            34   25  34 1