Cefepime hydrochloride

Entry

D01157                      Drug

Name

Cefepime hydrochloride (USP);
Cefepime dihydrochloride hydrate (JP18);
Maxipime (TN)

Product

CEFEPIME (Baxter Healthcare Corporation), CEFEPIME HYDROCHLORIDE AND DEXTROSE (B. Braun Medical)

Generic

CEFEPIME (Apotex Corp.), CEFEPIME (Apotex Corp.), CEFEPIME (Apotex Corp.), CEFEPIME (Fresenius Kabi USA), CEFEPIME (Hospira), CEFEPIME (Piramal Critical Care), CEFEPIME (SAMSON MEDICAL TECHNOLOGIES LLC), CEFEPIME (WG Critical Care), CEFEPIME (WG Critical Care), CEFEPIME (Meitheal Pharmaceuticals), CEFEPIME (Meitheal Pharmaceuticals), CEFEPIME (Qilu Pharmaceutical), CEFEPIME (Sagent Pharmaceuticals), CEFEPIME (Sagent Pharmaceuticals), CEFEPIME HYDROCHLORIDE (Xellia Pharmaceuticals USA LLC)

Formula

C19H25N6O5S2. HCl. Cl. H2O

Exact mass

570.0889

Mol weight

571.4982

Structure

Simcomp

Class

Antibacterial
DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
DG01777  Fourth-generation cephalosporin
DG01804  Oxyimino beta-lactam

Remark

Same as:

C12557

Therapeutic category:

6132

ATC code:

J01DE01

Chemical structure group:

DG00586

Product (DG00586):

D01157<JP/US>

Efficacy

Antibacterial, Cell wall biosynthesis inhibitor

Disease

Uncomplicated and complicated urinary tract infections [DS:H01176]

Target

penicillin binding protein

Pathway

ko00550

Peptidoglycan biosynthesis

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DE Fourth-generation cephalosporins
     J01DE01 Cefepime
      D01157  Cefepime hydrochloride (USP) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
  Beta-lactam, Cephalosporins
   Cefepime
    D01157  Cefepime hydrochloride (USP)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D01157  Cefepime hydrochloride (USP); Cefepime dihydrochloride hydrate (JP18)
Drug groups [BR:br08330]
Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00586  Cefepime
      D01157  Cefepime hydrochloride
  DG01777  Fourth-generation cephalosporin
   DG00586  Cefepime
    D01157  Cefepime hydrochloride
  DG01804  Oxyimino beta-lactam
   DG00586  Cefepime
    D01157  Cefepime hydrochloride
Drug classes [BR:br08332]
Antibacterial
  DG01488  Cephem
   D01157  Cefepime hydrochloride
Antimicrobials [BR:br08307]
Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Fourth-generation cephalosporin
    D01157  Cefepime hydrochloride (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D01157  Cefepime dihydrochloride hydrate
  D01157  Cefepime dihydrochloride for injection
Drug groups [BR:br08330]
Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00586  Cefepime
  DG01777  Fourth-generation cephalosporin
   DG00586  Cefepime
  DG01804  Oxyimino beta-lactam
   DG00586  Cefepime
Antimicrobials abbreviations [BR:br08327]
Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Fourth-generation cephalosporin
    DG00586  Cefepime

Other DBs

CAS:	123171-59-5

PubChem:

7848220

ChEBI:

31368

LigandBox:

D01157

KCF data

ATOM        35
            1   X   Cl   19.3672  -22.6156
            2   X   Cl   29.6799  -18.2084 #-
            3   O0  O    22.4824  -22.5456
            4   C1y C    26.0672  -18.8627
            5   N1y N    26.0672  -20.2534
            6   C2y C    27.2717  -20.9487
            7   C2y C    28.4761  -20.2534
            8   C1x C    28.4761  -18.8627
            9   S2x S    27.2717  -18.1673
            10  C1y C    24.6764  -18.8627
            11  C5x C    24.6764  -20.2534
            12  N1b N    23.4722  -18.1673
            13  C5a C    22.2677  -18.8627
            14  O5a O    22.2677  -20.2534
            15  O5x O    23.4722  -20.9487
            16  C2c C    21.0633  -18.1673
            17  C1b C    29.6990  -20.9598
            18  C8y C    19.8396  -18.8743
            19  N2y N    30.9084  -20.2618 #+
            20  C8x C    18.7080  -18.0429
            21  S2x S    17.5629  -18.8608
            22  C8y C    17.9869  -20.2027
            23  N5x N    19.3940  -20.2140
            24  N2b N    21.0632  -16.7553
            25  C6a C    27.2717  -22.3560
            26  O6a O    28.4867  -23.0575
            27  O6a O    26.0583  -23.0567
            28  C1x C    30.9086  -18.8509
            29  C1x C    32.2501  -20.6980
            30  C1x C    33.0795  -19.5567
            31  C1x C    32.2504  -18.4151
            32  C1a C    30.9084  -21.6640
            33  N1a N    17.1436  -21.3437
            34  O2a O    22.2916  -16.0462
            35  C1a C    22.2922  -14.6304
BOND        35
            1     4   5 1
            2     5   6 1
            3     6   7 2
            4     7   8 1
            5     8   9 1
            6     4   9 1
            7     4  10 1
            8    10  11 1
            9     5  11 1
            10   10  12 1 #Up
            11   12  13 1
            12   13  14 2
            13   11  15 2
            14   13  16 1
            15    7  17 1
            16   16  18 1
            17   17  19 1
            18   18  20 2
            19   20  21 1
            20   21  22 1
            21   22  23 2
            22   18  23 1
            23   16  24 2
            24    6  25 1
            25   25  26 1
            26   25  27 2
            27   19  28 1
            28   19  29 1
            29   29  30 1
            30   30  31 1
            31   28  31 1
            32   19  32 1
            33   22  33 1
            34   24  34 1
            35   34  35 1