Entry

D01192                      Drug

Name

Olopatadine hydrochloride (JP18/USP);
Allelock (TN);
Patanol (TN);
Opatanol (TN)

Product

PATANASE (Novartis Pharmaceuticals Corporation)

Generic

OLOPATADINE (A-S Medication Solutions), OLOPATADINE HYDROCHLORIDE (A-S Medication Solutions), OLOPATADINE (A-S Medication Solutions), OLOPATADINE (Akorn), OLOPATADINE (Akorn), OLOPATADINE HYDROCHLORIDE (Alembic Pharmaceuticals), OLOPATADINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), OLOPATADINE HYDROCHLORIDE (Apotex Corp.), OLOPATADINE HYDROCHLORIDE (Apotex Corp.), OLOPATADINE HYDROCHLORIDE (Apotex Corp.), OLOPATADINE HYDROCHLORIDE (Asclemed USA), OLOPATADINE HYDROCHLORIDE (Bryant Ranch Prepack), OLOPATADINE HYDROCHLORIDE (Direct Rx), OLOPATADINE (Golden State Medical Supply), OLOPATADINE HYDROCHLORIDE (NuCare Pharmaceuticals), OLOPATADINE HYDROCHLORIDE (Padagis Israel Pharmaceuticals), OLOPATADINE HYDROCHLORIDE (Preferred Pharmaceuticals), OLOPATADINE HYDROCHLORIDE (Proficient Rx LP), OLOPATADINE HYDROCHLORIDE (RPK Pharmaceuticals), OLOPATADINE HYDROCHLORIDE (Sandoz), OLOPATADINE HYDROCHLORIDE (Sandoz), OLOPATADINE HYDROCHLORIDE (Sandoz), OLOPATADINE HYDROCHLORIDE (Somerset Therapeutics), OLOPATADINE HYDROCHLORIDE (Akorn), OLOPATADINE HYDROCHLORIDE (Rising Pharmaceuticals)

Formula

C21H23NO3. HCl

Exact mass

373.1445

Mol weight

373.8732

Structure

Simcomp

Class

Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist

Remark

Therapeutic category:

1319 4490

ATC code:

R01AC08 S01GX09

Chemical structure group:

DG01039

Product (DG01039):

D01192<JP/US>

Efficacy

Antiallergic, H1 receptor antagonist

Disease

Seasonal allergic rhinitis [DS:H01360]

Comment

Loratadine derivative

Target

HRH1 [HSA:3269] [KO:K04149]

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

Interaction

Structure map

map07212

Histamine H1 receptor antagonists

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AC Antiallergic agents, excl. corticosteroids
     R01AC08 Olopatadine
      D01192  Olopatadine hydrochloride (JP18/USP) <JP/US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GX Other antiallergics
     S01GX09 Olopatadine
      D01192  Olopatadine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Ophthalmic Agents
  Ophthalmic Anti-allergy Agents
   Antihistamine
    Olopatadine
     D01192  Olopatadine hydrochloride (JP18/USP)
Respiratory Tract/Pulmonary Agents
  Antihistamines
   Histamine (H1) Receptor Antagonists, Mildly/Non-sedating
    Olopatadine
     D01192  Olopatadine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D01192  Olopatadine hydrochloride (JP18/USP)
4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D01192  Olopatadine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01039  Olopatadine
     D01192  Olopatadine hydrochloride
Drug classes [BR:br08332]
Anti-allergic agent
  DG01482  Histamine receptor H1 antagonist
   D01192  Olopatadine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D01192  Olopatadine hydrochloride (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D01192  Olopatadine hydrochloride
  D01192  Olopatadine hydrochloride tablets
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D01192
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D01192
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D01192
Rx-to-OTC switch list in the USA [br08315.html]
D01192
Drug groups [BR:br08330]
Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01039  Olopatadine

Other DBs

CAS:	140462-76-6

PubChem:

7848255

ChEBI:

31933

LigandBox:

D01192

NIKKAJI:

J508.357E

KCF data

ATOM        26
            1   X   Cl   25.5488  -17.6013
            2   O2x O    18.4771  -20.2698
            3   C8y C    17.6355  -19.1476
            4   C8y C    17.9161  -17.7450
            5   C2y C    19.1785  -17.1839
            6   C1x C    19.8798  -20.2698
            7   C8y C    20.4409  -17.8151
            8   C8y C    20.7214  -19.2178
            9   C8x C    16.9341  -16.7630
            10  C8y C    15.6016  -17.1839
            11  C8x C    15.2509  -18.5165
            12  C8x C    16.2328  -19.4983
            13  C8x C    22.1241  -19.6385
            14  C8x C    23.1060  -18.6567
            15  C8x C    22.8254  -17.3241
            16  C8x C    21.4929  -16.9034
            17  C2b C    19.1785  -15.7812
            18  C1b C    14.5495  -16.2021
            19  C6a C    13.2170  -16.6228
            20  O6a O    12.2351  -15.6410
            21  O6a O    12.8664  -17.9554
            22  C1b C    17.9865  -15.0638
            23  C1b C    17.9865  -13.6646
            24  N1c N    16.7747  -12.9650
            25  C1a C    15.5841  -13.6522
            26  C1a C    16.7746  -11.5441
BOND        27
            1     4   5 1
            2     2   6 1
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     4   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    3  12 2
            13    8  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17    7  16 2
            18    5  17 2
            19   10  18 1
            20   18  19 1
            21   19  20 1
            22   19  21 2
            23   17  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   24  26 1