Acetazolamide sodium

Entry

D01196                      Drug

Name

Acetazolamide sodium (JAN);
Diamox (TN)

Product

Generic

ACETAZOLAMIDE (Cadila Healthcare Limited), ACETAZOLAMIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), ACETAZOLAMIDE (Hikma Pharmaceuticals USA), ACETAZOLAMIDE (Hikma Pharmaceuticals USA), ACETAZOLAMIDE (XGen Pharmaceuticals DJB), ACETAZOLAMIDE (Zydus Pharmaceuticals (USA)), ACETAZOLAMIDE (Mylan Institutional LLC)

Formula

C4H5N4O3S2. Na

Exact mass

243.9701

Mol weight

244.2273

Structure

Simcomp

Class

Cardiovascular agent
DG01534 Carbonic anhydrase inhibitor
Ophthalmic agent
DG03201 Intraocular pressure lowering agent

Remark

Therapeutic category:

2134

ATC code:

S01EC01

Chemical structure group:

DG01134

Product (DG01134):

D00218<JP/US> D01196<JP/US>

Efficacy

Antiglaucoma, Carbonic anhydrase inhibitor

Disease

Chronic simple (open-angle) glaucoma [DS:H00612]

Comment

Sulfonamide derivative
Diuretic action

Target

CA [HSA:759 760 761 762 763 11238 765 766 767 768 771 377677 23632] [KO:K01672 K18245 K18246]

Pathway

hsa04964

Proximal tubule bicarbonate reclamation

Interaction

Structure map

map07017

Sulfonamide derivatives - diuretics

map07033

Anticonvulsants

map07054

Antiglaucoma agents

map07055

Sulfonamide derivatives - overview

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EC Carbonic anhydrase inhibitors
     S01EC01 Acetazolamide
      D01196  Acetazolamide sodium (JAN) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
  Cardiovascular Agents, Other
   Acetazolamide
    D01196  Acetazolamide sodium (JAN)
Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Carbonic Anhydrase Inhibitors, Ophthalmic
    Acetazolamide
     D01196  Acetazolamide sodium (JAN)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2134  Carbonic anhydrase inhibitors
     D01196  Acetazolamide sodium (JAN)
Drug groups [BR:br08330]
Cardiovascular agent
  DG01534  Carbonic anhydrase inhibitor
   DG01134  Acetazolamide
    D01196  Acetazolamide sodium
Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG01134  Acetazolamide
    D01196  Acetazolamide sodium
Drug classes [BR:br08332]
Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D01196  Acetazolamide sodium
Target-based classification of drugs [BR:br08310]
Enzymes
  Lyases (EC4)
   Aldehyde-lyases
    CA
     D01196  Acetazolamide sodium (JAN) <JP/US>
Drug groups [BR:br08330]
Cardiovascular agent
  DG01534  Carbonic anhydrase inhibitor
   DG01134  Acetazolamide
Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG01134  Acetazolamide

Other DBs

CAS:

1424-27-7

PubChem:

7848259

ChEBI:

31163

LigandBox:

D01196

NIKKAJI:

J24.636K

KCF data

ATOM        14
            1   N5x N    25.5209  -16.3791
            2   C8y C    25.9582  -15.0505
            3   S2x S    24.8212  -14.2224
            4   C8y C    23.6844  -15.0505
            5   N5x N    24.1217  -16.3791
            6   N1b N    27.1654  -14.3451
            7   C5a C    28.3702  -15.0373
            8   C1a C    29.5819  -14.3378
            9   O5a O    28.3733  -16.4368
            10  S4a S    22.2790  -15.0465
            11  O3c O    22.2790  -13.6470
            12  O3c O    20.8795  -15.0465
            13  N1a N    22.2790  -16.4461 #-
            14  Z   Na   19.6199  -17.1459 #+
BOND        13
            1     6   7 1
            2     1   2 2
            3     7   8 1
            4     2   3 1
            5     7   9 2
            6     3   4 1
            7     4   5 2
            8     5   1 1
            9     2   6 1
            10    4  10 1
            11   10  11 2
            12   10  12 2
            13   10  13 1