Emtricitabine

Entry

D01199                      Drug

Name

Emtricitabine (JAN/USAN/INN);
Emtriva (TN)

Abbr

FTC

Product

EMTRIVA (Gilead Sciences), EMTRIVA (REMEDYREPACK)

Generic

EMTRICITABINE (Cipla USA), EMTRICITABINE (REMEDYREPACK)

Formula

C8H10FN3O3S

Exact mass

247.0427

Mol weight

247.2467

Structure

Simcomp

Class

Antiviral
DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
DG01440  Arabinofuranosyl type antiviral
DG03107  Anti-HIV agent
  DG01656  HIV reverse transcriptase inhibitor
Transporter substrate
DG02860  SLC22A8 substrate

Remark

Same as:

C12599

Therapeutic category:

6250

ATC code:

J05AF09

Product:

D01199<JP/US>

Product (mixture):

D02297<JP/US> D10571<US> D10755<JP/US> D10756<JP/US> D10835<JP/US> D10836<JP/US> D10851<US> D11039<JP/US> D11382<JP/US>

Efficacy

Antiviral, Reverse transcriptase inhibitor

Disease

HIV-1 infection [DS:H01563]

Target

HIV-1 reverse transcriptase [KO:K24802]

Pathway

ko03230

Viral genome structure

ko03240

Viral replication

ko03250

Viral life cycle - HIV-1

Metabolism

Transporter: SLC22A8 [HSA:9376]

Interaction

Structure map

map07053

Anti-HIV agents

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF09 Emtricitabine
      D01199  Emtricitabine (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Antivirals
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)
   Emtricitabine
    D01199  Emtricitabine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D01199  Emtricitabine (JAN/USAN/INN)
Drug groups [BR:br08330]
Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   D01199  Emtricitabine
  DG01440  Arabinofuranosyl type antiviral
   D01199  Emtricitabine
  DG03107  Anti-HIV agent
   DG01656  HIV reverse transcriptase inhibitor
    D01199  Emtricitabine
Transporter substrate
  DG02860  SLC22A8 substrate
   D01199  Emtricitabine
Drug classes [BR:br08332]
Antiviral
  DG03107  Anti-HIV agent
   D01199  Emtricitabine
Antimicrobials [BR:br08307]
Antivirals
  Genome replication inhibitor
   HIV reverse transcriptase inhibitor
    D01199  Emtricitabine (JAN/USAN/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antivirals
  Genome replication inhibitor
   HIV reverse transcriptase inhibitor
    D01199  Emtricitabine (JAN/USAN/INN)
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D01199
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D01199
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D01199
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D01199
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
  D01199

Other DBs

CAS:	143491-57-0

PubChem:

7848262

ChEBI:

31536

PDB-CCD:

ETV[PDBj]

LigandBox:

D01199

KCF data

ATOM        16
            1   N4y N    25.0103  -17.6390
            2   C1y C    23.6350  -18.1111
            3   C1y C    21.3970  -18.1111
            4   C1b C    20.1381  -17.4117
            5   O1a O    18.9492  -18.1111
            6   S2x S    21.8166  -19.4399
            7   O2x O    22.5160  -17.2718
            8   C1x C    23.2154  -19.4399
            9   C8x C    25.0206  -16.2402
            10  C8y C    26.2146  -15.5496
            11  C8y C    27.4684  -16.2582
            12  N5x N    27.4581  -17.6570
            13  C8y C    26.2641  -18.3476
            14  N1a N    28.6624  -15.5676
            15  X   F    26.1549  -14.1509
            16  O5x O    26.2538  -19.7463
BOND        17
            1     8   6 1
            2     4   5 1
            3     2   1 1 #Down
            4     3   4 1 #Down
            5     6   3 1
            6     1   9 1
            7     9  10 2
            8    10  11 1
            9    11  12 2
            10   12  13 1
            11   13   1 1
            12    3   7 1
            13   11  14 1
            14    7   2 1
            15   10  15 1
            16    2   8 1
            17   13  16 2