Difluprednate


Entry
D01266                      Drug                                   
Name
Difluprednate (JAN/USAN/INN);
Durezol (TN)
Product
DUREZOL (Novartis Pharmaceuticals Corporation), DUREZOL (Alcon Laboratories)
  Generic
DIFLUPREDNATE (Cipla USA), DIFLUPREDNATE (Exelan Pharmaceuticals), DIFLUPREDNATE (Amneal Pharmaceuticals NY LLC), DIFLUPREDNATE OPHTHALMIC (Sandoz)
Formula
C27H34F2O7
Exact mass
508.2273
Mol weight
508.5515
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Remark
Same as: C12695
Therapeutic category: 2646
ATC code: D07AC19
Product: D01266<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC19 Difluprednate
      D01266  Difluprednate (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Glucocorticoids, Ophthalmic
    Difluprednate
     D01266  Difluprednate (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01266  Difluprednate (JAN/USAN/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    D01266  Difluprednate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01266  Difluprednate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01266  Difluprednate (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01266
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01266
Topical steroids potency [br08317.html]
 Classification in Japan
  D01266
Other DBs
CAS: 23674-86-4
PubChem: 7848329
ChEBI: 31485
LigandBox: D01266
NIKKAJI: J15.820H
KCF data

ATOM        36
            1   C1z C    23.2566  -15.7189
            2   C1z C    22.0669  -16.3838
            3   C1x C    24.4349  -16.4188
            4   C5a C    23.2800  -14.0508
            5   O7a O    24.4523  -15.0131
            6   C1y C    22.0435  -17.7543
            7   C1x C    20.8770  -15.6956
            8   C1a C    22.0552  -14.9899
            9   C1x C    24.4173  -17.7894
            10  C1b C    22.0900  -13.3392
            11  O5a O    24.4930  -13.3742
            12  C7a C    25.8345  -15.0131
            13  C1y C    20.8536  -18.4252
            14  C1y C    19.6930  -16.3605
            15  O7a O    20.8829  -14.0274
            16  C1b C    26.5170  -13.8174
            17  O6a O    26.5286  -16.2147
            18  C1z C    19.6813  -17.7369
            19  C1x C    20.8536  -19.7900
            20  O1a O    18.5032  -15.6839
            21  C7a C    19.6813  -13.3334
            22  C1b C    27.8992  -13.8174
            23  C1z C    18.4916  -18.4135
            24  X   F    19.6696  -19.0958
            25  C1y C    19.6696  -20.4723
            26  C1a C    18.4857  -14.0274
            27  O6a O    19.6756  -11.9453
            28  C2y C    18.4857  -19.7840
            29  C2x C    17.3076  -17.7310
            30  C2x C    17.3076  -20.4665
            31  C2x C    16.1293  -18.4135
            32  C5x C    16.1293  -19.7840
            33  O5x O    14.9396  -20.4606
            34  X   F    19.6669  -21.8677
            35  C1a C    18.4784  -17.0159
            36  C1a C    28.5969  -12.6089
BOND        39
            1     1   4 1 #Up
            2     1   5 1 #Down
            3     2   6 1
            4     2   7 1
            5     2   8 1 #Up
            6     3   9 1
            7     4  10 1
            8     4  11 2
            9     5  12 1
            10    6  13 1
            11    7  14 1
            12   10  15 1
            13   12  16 1
            14   12  17 2
            15   13  18 1
            16   13  19 1
            17   14  20 1 #Up
            18   15  21 1
            19   16  22 1
            20   18  23 1
            21   18  24 1 #Down
            22   19  25 1
            23   21  26 1
            24   21  27 2
            25   23  28 1
            26   23  29 1
            27   28  30 2
            28   29  31 2
            29   30  32 1
            30   32  33 2
            31    6   9 1
            32   14  18 1
            33   25  28 1
            34   31  32 1
            35   25  34 1 #Down
            36    1   2 1
            37   23  35 1 #Up
            38    1   3 1
            39   22  36 1