Cloxazolam


Entry
D01268                      Drug                                   
Name
Cloxazolam (JP18/INN);
Sepazon (TN)
Formula
C17H14Cl2N2O2
Exact mass
348.0432
Mol weight
349.2113
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG01914  Anxiolytics, benzodiazepine derivatives
Remark
Therapeutic category: 1124
ATC code: N05BA22
Product: D01268<JP>
Efficacy
Antianxiety, Minor tranquilizer, Sedative-hypnotic
Comment
Benzodiazepine derivative
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Structure map
map07030  Anxiolytics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA22 Cloxazolam
      D01268  Cloxazolam (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01268  Cloxazolam (JP18/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01567  GABA-A receptor agonist
   D01268  Cloxazolam
  DG01914  Anxiolytics, benzodiazepine derivatives
   D01268  Cloxazolam
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D01268  Cloxazolam (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01268  Cloxazolam
Other DBs
CAS: 24166-13-0
PubChem: 7848331
ChEBI: 31426
LigandBox: D01268
NIKKAJI: J3.158E
KCF data

ATOM        23
            1   C1z C    29.3673  -18.9577
            2   C8y C    28.5306  -17.8552
            3   C8y C    28.8637  -16.5071
            4   N1x N    30.1166  -15.9327
            5   N1y N    30.7641  -18.9827
            6   C5x C    31.3621  -16.5510
            7   C1x C    31.6468  -17.9110
            8   C8x C    27.8630  -15.5449
            9   C8x C    26.5296  -15.9306
            10  C8y C    26.1966  -17.2786
            11  C8x C    27.1972  -18.2405
            12  O5x O    32.3995  -15.6226
            13  X   Cl   24.8406  -17.6705
            14  O2x O    28.9118  -20.2784
            15  C1x C    30.0272  -21.1197
            16  C1x C    31.1719  -20.3189
            17  C8y C    27.6759  -19.6654
            18  C8y C    27.6759  -21.0565
            19  C8x C    26.4712  -18.9699
            20  C8x C    25.2666  -19.6654
            21  C8x C    25.2666  -21.0565
            22  C8x C    26.4712  -21.7520
            23  X   Cl   28.8923  -21.7591
BOND        26
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    6  12 2
            14   10  13 1
            15    1  14 1
            16   14  15 1
            17   15  16 1
            18    5  16 1
            19    1  17 1
            20   17  18 1
            21   17  19 2
            22   19  20 1
            23   20  21 2
            24   21  22 1
            25   18  22 2
            26   18  23 1