Solifenacin succinate


Entry
D01269                      Drug                                   
Name
Solifenacin succinate (JAN/USAN/INN);
Vesicare (TN)
Product
VESICARE (Astellas Pharma US), VESICARE (Astellas Pharma US)
  Generic
SOLIFENACIN (Cadila Healthcare Limited), SOLIFENACIN SUCCINATE (AustarPharma LLC), SOLIFENACIN SUCCINATE (AvKARE), SOLIFENACIN SUCCINATE (Golden State Medical Supply), SOLIFENACIN SUCCINATE (Proficient Rx LP), SOLIFENACIN SUCCINATE (Proficient Rx LP), SOLIFENACIN SUCCINATE (Westminster Pharmaceuticals), SOLIFENACIN SUCCINATE (Actavis Pharma), SOLIFENACIN SUCCINATE (Ajanta Pharma USA), SOLIFENACIN SUCCINATE (Alembic Pharmaceuticals), SOLIFENACIN SUCCINATE (Alembic Pharmaceuticals Limited), SOLIFENACIN SUCCINATE (Amneal Pharmaceuticals NY LLC), SOLIFENACIN SUCCINATE (Apotex Corp.), SOLIFENACIN SUCCINATE (Ascend Laboratories), SOLIFENACIN SUCCINATE (Bryant Ranch Prepack), SOLIFENACIN SUCCINATE (Bryant Ranch Prepack), SOLIFENACIN SUCCINATE (Bryant Ranch Prepack), SOLIFENACIN SUCCINATE (Bryant Ranch Prepack), SOLIFENACIN SUCCINATE (Bryant Ranch Prepack), SOLIFENACIN SUCCINATE (Bryant Ranch Prepack), SOLIFENACIN SUCCINATE (Bryant Ranch Prepack), SOLIFENACIN SUCCINATE (CELLTRION USA), SOLIFENACIN SUCCINATE (Camber Pharmaceuticals), SOLIFENACIN SUCCINATE (Glenmark Pharmaceuticals), SOLIFENACIN SUCCINATE (Golden State Medical Supply), SOLIFENACIN SUCCINATE (Graviti Pharmaceuticals Private Limited), SOLIFENACIN SUCCINATE (MSN LABORATORIES PRIVATE LIMITED), SOLIFENACIN SUCCINATE (Novadoz Pharmaceuticals LLC), SOLIFENACIN SUCCINATE (Proficient Rx LP), SOLIFENACIN SUCCINATE (Proficient Rx LP), SOLIFENACIN SUCCINATE (Proficient Rx LP), SOLIFENACIN SUCCINATE (Proficient Rx LP), SOLIFENACIN SUCCINATE (Proficient Rx LP), SOLIFENACIN SUCCINATE (REMEDYREPACK), SOLIFENACIN SUCCINATE (ScieGen Pharmaceuticals), SOLIFENACIN SUCCINATE (Unichem Pharmaceuticals (USA)), SOLIFENACIN SUCCINATE (Westminster Pharmaceuticals), SOLIFENACINE SUCCINATE (Cipla USA)
Formula
C23H26N2O2. C4H6O4
Exact mass
480.226
Mol weight
480.5528
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2590
ATC code: G04BD08
Chemical structure group: DG00481
Product (DG00481): D01269<JP/US>
Efficacy
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist
Comment
Treatment for relief of symptoms of urinary frequency, urinary urgency, or urge urinary incontinence (UUI) associated with an overactive bladder
Target
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD08 Solifenacin
      D01269  Solifenacin succinate (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Genitourinary Agents
  Antispasmodics, Urinary
   Solifenacin
    D01269  Solifenacin succinate (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D01269  Solifenacin succinate (JAN/USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00481  Solifenacin
    D01269  Solifenacin succinate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00481  Solifenacin
     D01269  Solifenacin succinate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM3
     D01269  Solifenacin succinate (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01269
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01269
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01269
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01269
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00481  Solifenacin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00481  Solifenacin
Other DBs
CAS: 242478-38-2
PubChem: 7848332
ChEBI: 32151
LigandBox: D01269
NIKKAJI: J1.594.870A
KCF data

ATOM        35
            1   C6a C    27.3377  -15.6723
            2   C1b C    26.1211  -16.3800
            3   O6a O    28.5603  -16.3800
            4   O6a O    27.3377  -14.2742
            5   C1b C    24.9102  -15.6781
            6   C6a C    23.6994  -16.3858
            7   O6a O    22.4826  -15.6840
            8   O6a O    23.6994  -17.7839
            9   C1y C    18.3613  -14.7461
            10  C1x C    18.3613  -13.3364
            11  C1y C    17.1446  -15.4538
            12  C1x C    19.5662  -15.4538
            13  C1x C    19.0456  -14.5531
            14  C1x C    17.8349  -16.6589
            15  C1x C    20.2564  -16.6589
            16  N1y N    19.0398  -15.9627
            17  C1x C    12.3002  -12.6575
            18  C1x C    13.5080  -13.3573
            19  N1y N    13.5080  -14.7568
            20  C1y C    12.3002  -15.4565
            21  C8y C    11.0852  -13.3573
            22  C8y C    11.0852  -14.7568
            23  C8x C     9.8734  -15.4565
            24  C8x C     8.6613  -14.7568
            25  C8x C     8.6613  -13.3573
            26  C8x C     9.8734  -12.6575
            27  C8y C    12.3020  -16.8560
            28  C8x C    13.5154  -17.5532
            29  C8x C    13.5171  -18.9527
            30  C8x C    12.3061  -19.6540
            31  C8x C    11.0932  -18.9558
            32  C8x C    11.0913  -17.5563
            33  C7a C    14.7205  -15.4555
            34  O7a O    15.9321  -14.7549
            35  O6a O    14.7216  -16.8550
BOND        38
            1     6   7 1
            2     6   8 2
            3     1   2 1
            4     1   3 1
            5     1   4 2
            6     2   5 1
            7     5   6 1
            8    21  17 1
            9    17  18 1
            10   18  19 1
            11   19  20 1
            12   20  22 1
            13    9  10 1
            14   21  22 2
            15   22  23 1
            16   23  24 2
            17   24  25 1
            18   25  26 2
            19   26  21 1
            20    9  11 1
            21   20  27 1 #Up
            22    9  12 1
            23   10  13 1
            24   11  14 1
            25   12  15 1
            26   13  16 1
            27   27  28 2
            28   28  29 1
            29   29  30 2
            30   30  31 1
            31   31  32 2
            32   32  27 1
            33   14  16 1
            34   19  33 1
            35   15  16 1
            36   33  34 1
            37   33  35 2
            38   11  34 1 #Down