Flutazolam


Entry
D01286                      Drug                                   
Name
Flutazolam (JAN/INN);
Coreminal (TN)
Formula
C19H18ClFN2O3
Exact mass
376.099
Mol weight
376.8092
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
 DG01914  Anxiolytics, benzodiazepine derivatives
Remark
Therapeutic category: 1124
Product: D01286<JP>
Efficacy
Antianxiety, Sedative-hypnotic
Comment
Benzodiazepine derivative
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Structure map
map07030  Anxiolytics
map07230  GABA-A receptor agonists/antagonists
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01286  Flutazolam (JAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01835  Benzodiazepine sedative-hypnotics
   D01286  Flutazolam
  DG01567  GABA-A receptor agonist
   D01286  Flutazolam
  DG01914  Anxiolytics, benzodiazepine derivatives
   D01286  Flutazolam
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D01286  Flutazolam (JAN/INN) <JP>
Other DBs
CAS: 27060-91-9
PubChem: 7848349
ChEBI: 31628
LigandBox: D01286
NIKKAJI: J3.166F
KCF data

ATOM        26
            1   C1z C    17.9931  -13.2478
            2   C8y C    17.1504  -12.1374
            3   C8y C    17.4859  -10.7797
            4   N1y N    18.7477  -10.2011
            5   N1y N    19.3999  -13.2030
            6   C5x C    20.0022  -10.8239
            7   C1x C    20.2889  -12.1936
            8   C8x C    16.4780   -9.8106
            9   C8x C    15.1351  -10.1989
            10  C8y C    14.7997  -11.5567
            11  C8x C    15.8075  -12.5255
            12  O5x O    21.0471   -9.8888
            13  X   Cl   13.4339  -11.9514
            14  C1b C    18.7695   -8.8253
            15  C1b C    19.9878   -8.1473
            16  O1a O    20.0098   -6.7200
            17  O2x O    17.6010  -14.5996
            18  C1x C    18.7654  -15.3903
            19  C1x C    19.8772  -14.5271
            20  C8y C    16.2907  -13.9478
            21  C8x C    15.0782  -13.2478
            22  C8x C    13.8658  -13.9478
            23  C8x C    13.8658  -15.3478
            24  C8x C    15.0782  -16.0478
            25  C8y C    16.2907  -15.3478
            26  X   F    17.5096  -16.0517
BOND        29
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    6  12 2
            14   10  13 1
            15    4  14 1
            16   14  15 1
            17   15  16 1
            18    1  17 1
            19   17  18 1
            20   18  19 1
            21    5  19 1
            22    1  20 1
            23   20  21 2
            24   21  22 1
            25   22  23 2
            26   23  24 1
            27   24  25 2
            28   20  25 1
            29   25  26 1