Halcinonide


Entry
D01308                      Drug                                   
Name
Halcinonide (JAN/USP/INN);
Halog (TN)
Product
HALOG (Sun Pharmaceutical Industries), HALOG (Sun Pharmaceutical Industries), HALOG (Sun Pharmaceutical Industries)
  Generic
HALCINONIDE (Glasshouse Pharmaceuticals Limited Canada), HALCINONIDE (Mylan Pharmaceuticals), HALCINONIDE (Sun Pharmaceutical Industries)
Formula
C24H32ClFO5
Exact mass
454.1922
Mol weight
454.9593
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
Remark
ATC code: D07AD02
Product: D01308<US>
Efficacy
Anti-inflammatory (topical), Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AD Corticosteroids, very potent (group IV)
     D07AD02 Halcinonide
      D01308  Halcinonide (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, High Potency
    Halcinonide
     D01308  Halcinonide (JAN/USP/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01308  Halcinonide
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01308  Halcinonide
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01308  Halcinonide (JAN/USP/INN) <US>
Topical steroids potency [br08317.html]
 Classification in the USA
  D01308
 Classification in Japan
  D01308
Other DBs
CAS: 3093-35-4
PubChem: 7848371
ChEBI: 31663
LigandBox: D01308
NIKKAJI: J3.398G
KCF data

ATOM        31
            1   C1x C    18.9000  -29.3300
            2   C5x C    18.9000  -30.7300
            3   C2x C    20.0900  -31.4300
            4   C2y C    21.2800  -30.7300
            5   C1z C    21.2800  -29.3300
            6   C1x C    20.0900  -28.7000
            7   C1x C    22.4700  -31.4300
            8   C1x C    23.7300  -30.7300
            9   C1y C    23.7300  -29.3300
            10  C1z C    22.4700  -28.7000
            11  C1y C    24.9200  -28.7000
            12  C1z C    24.9200  -27.3000
            13  C1x C    23.7300  -26.6000
            14  C1y C    22.4700  -27.3000
            15  C1a C    21.2800  -28.0000
            16  O1a O    21.2800  -26.6000
            17  C1a C    24.9200  -25.9000
            18  X   F    22.4700  -30.0300
            19  O5x O    17.7100  -31.4300
            20  C1x C    27.3449  -28.7000
            21  C1y C    27.3449  -27.3000
            22  C1z C    26.1324  -26.6000
            23  C5a C    26.1324  -25.0602
            24  C1b C    24.9032  -24.3503
            25  O5a O    27.3280  -24.3698
            26  X   Cl   23.6992  -25.0454
            27  O2x O    27.3279  -25.9096
            28  O2x O    28.6704  -26.7814
            29  C1z C    28.7279  -25.9096
            30  C1a C    28.7279  -24.5096
            31  C1a C    30.1279  -25.9096
BOND        35
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   10  14 1
            17    5  15 1 #Up
            18   14  16 1 #Up
            19   12  17 1 #Up
            20   10  18 1 #Down
            21    2  19 2
            22   11  20 1
            23   20  21 1
            24   21  22 1
            25   12  22 1
            26   22  23 1 #Up
            27   23  24 1
            28   23  25 2
            29   24  26 1
            30   22  27 1 #Down
            31   21  28 1 #Down
            32   27  29 1
            33   29  28 1
            34   29  30 1
            35   29  31 1