Meclizine hydrochloride


Entry
D01317                      Drug                                   
Name
Meclizine hydrochloride (JAN/USP);
Meclizine dihydrochloride monohydrate;
Antivert (TN)
Product
ANTIVERT (Casper Pharma LLC)
  Generic
MECLIZINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), MECLIZINE HYDROCHLORIDE (AvPAK), MECLIZINE HYDROCHLORIDE (Bryant Ranch Prepack), MECLIZINE (DIRECT RX), MECLIZINE HYDROCHLORIDE (Major Pharmaceuticals), MECLIZINE HYDROCHLORIDE (NCS HealthCare of KY), MECLIZINE HYDROCHLORIDE (REMEDYREPACK), MECLIZINE HYDROCHLORIDE (A-S Medication Solutions), MECLIZINE HYDROCHLORIDE (A-S Medication Solutions), MECLIZINE HYDROCHLORIDE (A-S Medication Solutions), MECLIZINE HYDROCHLORIDE (ANI Pharmaceuticals), MECLIZINE HYDROCHLORIDE (American Health Packaging), MECLIZINE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), MECLIZINE HYDROCHLORIDE (AvKARE), MECLIZINE HYDROCHLORIDE (Bryant Ranch Prepack), MECLIZINE HYDROCHLORIDE (Bryant Ranch Prepack), MECLIZINE HYDROCHLORIDE (Bryant Ranch Prepack), MECLIZINE HYDROCHLORIDE (Bryant Ranch Prepack), MECLIZINE HYDROCHLORIDE (Bryant Ranch Prepack), MECLIZINE HYDROCHLORIDE (Bryant Ranch Prepack), MECLIZINE HYDROCHLORIDE (Cadila Healthcare Limited), MECLIZINE HYDROCHLORIDE (DIRECT RX), MECLIZINE HYDROCHLORIDE (Denton Pharma), MECLIZINE HYDROCHLORIDE (Denton Pharma), MECLIZINE HYDROCHLORIDE (DirectRx), MECLIZINE HYDROCHLORIDE (Direct_Rx), MECLIZINE HYDROCHLORIDE (Direct_Rx), MECLIZINE HYDROCHLORIDE (Direct_Rx), MECLIZINE HYDROCHLORIDE (Direct_Rx), MECLIZINE HYDROCHLORIDE (Direct_Rx), MECLIZINE HYDROCHLORIDE (Epic Pharma LLC), MECLIZINE HYDROCHLORIDE (Golden State Medical Supply), MECLIZINE HYDROCHLORIDE (NCS HealthCare of KY), MECLIZINE HYDROCHLORIDE (Northwind Pharmaceuticals), MECLIZINE HYDROCHLORIDE (Nortic Pharma), MECLIZINE HYDROCHLORIDE (NuCare Pharmaceuticals), MECLIZINE HYDROCHLORIDE (NuCare Pharmaceuticals), MECLIZINE HYDROCHLORIDE (NuCare Pharmaceuticals), MECLIZINE HYDROCHLORIDE (NuCare Pharmaceuticals), MECLIZINE HYDROCHLORIDE (NuCare Pharmaceuticals), MECLIZINE HYDROCHLORIDE (NuCare Pharmaceuticals), MECLIZINE HYDROCHLORIDE (Proficient Rx LP), MECLIZINE HYDROCHLORIDE (Proficient Rx LP), MECLIZINE HYDROCHLORIDE (Proficient Rx LP), MECLIZINE HYDROCHLORIDE (Proficient Rx LP), MECLIZINE HYDROCHLORIDE (QPharma), MECLIZINE HYDROCHLORIDE (Quality Care Products), MECLIZINE HYDROCHLORIDE (Quality Care Products), MECLIZINE HYDROCHLORIDE (Quality Care Products), MECLIZINE HYDROCHLORIDE (REMEDYREPACK), MECLIZINE HYDROCHLORIDE (RedPharm Drug), MECLIZINE HYDROCHLORIDE (RedPharm Drug), MECLIZINE HYDROCHLORIDE (RedPharm Drug), MECLIZINE HYDROCHLORIDE (Rising Pharmaceuticals), MECLIZINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), MECLIZINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), MECLIZINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy), MECLIZINE HYDROCHLORIDE (Wilshire Pharmaceuticals), MECLIZINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), MECLIZINE HYDROCHLORIDE (A-S Medication Solutions), MECLIZINE HYDROCHLORIDE (A-S Medication Solutions), MECLIZINE HYDROCHLORIDE (Asclemed USA), MECLIZINE HYDROCHLORIDE (Bryant Ranch Prepack), MECLIZINE HYDROCHLORIDE (Bryant Ranch Prepack), MECLIZINE HYDROCHLORIDE (DOH CENTRAL PHARMACY), MECLIZINE HYDROCHLORIDE (Denton Pharma), MECLIZINE HYDROCHLORIDE (JUBILANT CADISTA PHARMACEUTICALS), MECLIZINE HYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), MECLIZINE HYDROCHLORIDE (NuCare Pharmaceuticals), MECLIZINE HYDROCHLORIDE (NuCare Pharmaceuticals), MECLIZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), MECLIZINE HYDROCHLORIDE (Proficient Rx LP), MECLIZINE HYDROCLORIDE (QPharma), MECLIZINE HYDROCHLORIDE (RPK Pharmaceuticals), MECLIZINE HYDROCHLORIDE (St. Mary's Medical Park Pharmacy)
Formula
C25H27ClN2. 2HCl. H2O
Exact mass
480.1502
Mol weight
481.8854
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
ATC code: R06AE05
Chemical structure group: DG01106
Product (DG01106): D01317<US>
Efficacy
Anti-emetic, H1 receptor antagonist
Comment
Meclizine is called Meclozine in INN.
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AE Piperazine derivatives
     R06AE05 Meclozine
      D01317  Meclizine hydrochloride (JAN/USP) <US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Meclizine
    D01317  Meclizine hydrochloride (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D01317  Meclizine hydrochloride (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Meclizine hydrochloride
    D01317  Meclizine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01106  Meclozine
     D01317  Meclizine hydrochloride
Drug classes [BR:br08332]
 Anti-allergic agent
  DG01482  Histamine receptor H1 antagonist
   D01317  Meclizine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D01317  Meclizine hydrochloride (JAN/USP) <US>
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01106  Meclozine
Other DBs
CAS: 31884-77-2
PubChem: 7848380
ChEBI: 31805
LigandBox: D01317
KCF data

ATOM        31
            1   X   Cl   36.2600  -17.3418
            2   O0  O    36.9062  -20.2833
            3   C8x C    25.6200  -20.5100
            4   C8y C    25.6200  -21.9100
            5   C8x C    26.8324  -22.6100
            6   C8x C    28.0449  -21.9100
            7   C8y C    28.0449  -20.5100
            8   C8x C    26.8324  -19.8100
            9   C8x C    30.4697  -21.9100
            10  C8y C    30.4697  -20.5100
            11  C1c C    29.2573  -19.8100
            12  C8x C    31.6822  -22.6100
            13  C8x C    32.8946  -21.9100
            14  C8x C    32.8946  -20.5100
            15  C8x C    31.6822  -19.8100
            16  N1y N    29.2573  -18.4100
            17  C1x C    30.4718  -17.7088
            18  C1x C    30.4718  -16.3088
            19  N1y N    29.2593  -15.6088
            20  C1x C    28.0449  -16.3100
            21  C1x C    28.0449  -17.7100
            22  C1b C    29.2593  -14.2100
            23  C8y C    30.4723  -13.5097
            24  C8x C    31.6680  -14.2002
            25  C8y C    32.8805  -13.5004
            26  C8x C    32.8807  -12.1004
            27  C8x C    31.6849  -11.4098
            28  C8x C    30.4724  -12.1097
            29  C1a C    34.1116  -14.2114
            30  X   Cl   24.4076  -22.6100
            31  X   Cl   36.2600  -17.3418
BOND        31
            1     3   4 2
            2     4   5 1
            3     5   6 2
            4     6   7 1
            5     7   8 2
            6     3   8 1
            7     9  10 1
            8    10  11 1
            9     7  11 1
            10    9  12 2
            11   12  13 1
            12   13  14 2
            13   14  15 1
            14   10  15 2
            15   11  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   16  21 1
            22   19  22 1
            23   22  23 1
            24   23  24 2
            25   24  25 1
            26   25  26 2
            27   26  27 1
            28   27  28 2
            29   23  28 1
            30   25  29 1
            31    4  30 1
BRACKET     1    34.5100  -18.3400   34.5100  -16.2400
            1    37.2400  -16.2400   37.2400  -18.3400
            1  2
 ORIGINAL  1    1
 REPEAT    1   31