Diflorasone diacetate

Entry

D01327                      Drug

Name

Diflorasone diacetate (JP18/USP);
Florone (TN);
Psorcon (TN)

Product

Generic

DIFLORASONE DIACETATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), DIFLORASONE DIACETATE (Emerald Therapeutics), DIFLORASONE DIACETATE (Innovida Pharmaceutique Corporation), APEXICON E (PharmaDerm a division of Fougera Pharmaceuticals), DIFLORASONE DIACETATE (Rising Pharmaceuticals), DIFLORASONE DIACETATE (Taro Pharmaceuticals U.S.A.), DIFLORASONE DIACETATE (Taro Pharmaceuticals U.S.A.), PSORCON (Taro Pharmaceuticals U.S.A.), DIFLORASONE DIACETATE (Teligent Pharma), DIFLORASONE DIACETATE OINT (Sola Pharmaceuticals)

Formula

C26H32F2O7

Exact mass

494.2116

Mol weight

494.5249

Structure

Simcomp

Class

Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid

Remark

Therapeutic category:

2646

ATC code:

D07AC10

Chemical structure group:

DG00418

Product (DG00418):

D01327<JP/US>

Efficacy

Anti-inflammatory, Glucocorticoid receptor agonist

Target

NR3C1 (GR) [HSA:2908] [KO:K05771]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AC Corticosteroids, potent (group III)
     D07AC10 Diflorasone
      D01327  Diflorasone diacetate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, High Potency
    Diflorasone
     D01327  Diflorasone diacetate (JP18/USP)
   Glucocorticoids, Very High Potency
    Diflorasone
     D01327  Diflorasone diacetate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01327  Diflorasone diacetate (JP18/USP)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00418  Diflorasone
     D01327  Diflorasone diacetate
Drug classes [BR:br08332]
Anti-inflammatory
  DG01955  Corticosteroid
   D01327  Diflorasone diacetate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01327  Diflorasone diacetate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D01327  Diflorasone diacetate
Topical steroids potency [br08317.html]
Classification in the USA
  D01327
Classification in Japan
  D01327
Drug groups [BR:br08330]
Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00418  Diflorasone

Other DBs

CAS:	33564-31-7

PubChem:

7848390

ChEBI:

31483

LigandBox:

D01327

NIKKAJI:

J17.484J

KCF data

ATOM        35
            1   C1z C    32.0564  -14.3706
            2   C1z C    30.9003  -15.0167
            3   C1y C    33.2015  -15.0507
            4   C5a C    32.0791  -12.5453
            5   O7a O    34.3069  -13.4125
            6   C1y C    30.8775  -16.3486
            7   C1x C    29.7439  -14.3479
            8   C1a C    30.8889  -13.6621
            9   C1x C    33.1844  -16.3826
            10  C1b C    30.9227  -11.8538
            11  O5a O    33.2580  -11.8878
            12  C7a C    35.6502  -13.4125
            13  C1y C    29.7211  -17.0006
            14  C1y C    28.5932  -14.9941
            15  O7a O    29.7496  -12.5227
            16  C1a C    36.3134  -12.2505
            17  O6a O    36.3248  -14.5802
            18  C1z C    28.5818  -16.3317
            19  C1x C    29.7211  -18.3268
            20  O1a O    27.4370  -14.3365
            21  C7a C    28.5818  -11.8482
            22  C1z C    27.4257  -16.9892
            23  X   F    28.5706  -17.6523
            24  C1y C    28.5706  -18.9900
            25  C1a C    27.4199  -12.5227
            26  O6a O    28.5763  -10.4991
            27  C2y C    27.4199  -18.3211
            28  C2x C    26.2751  -16.3260
            29  C1a C    27.4144  -15.6571
            30  C2x C    26.2751  -18.9844
            31  C2x C    25.1300  -16.9892
            32  C5x C    25.1300  -18.3211
            33  O5x O    23.9738  -18.9786
            34  C1a C    34.5562  -15.0488
            35  X   F    28.5635  -20.3431
BOND        38
            1     1   4 1 #Up
            2     1   5 1 #Down
            3     2   6 1
            4     2   7 1
            5     2   8 1 #Up
            6     3   9 1
            7     4  10 1
            8     4  11 2
            9     5  12 1
            10    6  13 1
            11    7  14 1
            12   10  15 1
            13   12  16 1
            14   12  17 2
            15   13  18 1
            16   13  19 1
            17   14  20 1 #Up
            18   15  21 1
            19   18  22 1
            20   18  23 1 #Down
            21   19  24 1
            22   21  25 1
            23   21  26 2
            24   22  27 1
            25   22  28 1
            26   22  29 1 #Up
            27   27  30 2
            28   28  31 2
            29   30  32 1
            30   32  33 2
            31    6   9 1
            32   14  18 1
            33   24  27 1
            34   31  32 1
            35    3  34 1 #Up
            36    1   2 1
            37    1   3 1
            38   24  35 1 #Down