Carbinoxamine maleate


Entry
D01336                      Drug                                   
Name
Carbinoxamine maleate (JAN/USP);
Clistin (TN);
Karbinal er (TN)
Product
KARBINAL (Aytu Therapeutics)
  Generic
CARBINOXAMINE MALEATE (Biocomp Pharma), CARBINOXAMINE MALEATE (Breckenridge Pharmaceutical), RYVENT (Carwin Pharmaceutical Associates), CARBINOXAMINE MALEATE (Foxland Pharmaceuticals)
Formula
C16H19ClN2O. C4H4O4
Exact mass
406.1296
Mol weight
406.86
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
ATC code: R06AA08
Chemical structure group: DG01095
Product (DG01095): D01336<US>
Efficacy
Antiallergic, H1 receptor antagonist
  Disease
Allergic rhinitis [DS:H01360]
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AA Aminoalkyl ethers
     R06AA08 Carbinoxamine
      D01336  Carbinoxamine maleate (JAN/USP) <US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Histamine (H1) Receptor Antagonists, Sedating
    Carbinoxamine
     D01336  Carbinoxamine maleate (JAN/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D01336  Carbinoxamine maleate (JAN/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Carbinoxamine
    D01336  Carbinoxamine maleate (JAN/USP)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01095  Carbinoxamine
     D01336  Carbinoxamine maleate
Drug classes [BR:br08332]
 Anti-allergic agent
  DG01482  Histamine receptor H1 antagonist
   D01336  Carbinoxamine maleate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D01336  Carbinoxamine maleate (JAN/USP) <US>
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01095  Carbinoxamine
Other DBs
CAS: 3505-38-2
PubChem: 7848399
ChEBI: 31353
LigandBox: D01336
NIKKAJI: J383.157D
KCF data

ATOM        28
            1   C6a C    34.1191  -18.0091
            2   C2b C    33.4156  -16.8836
            3   O6a O    33.4156  -19.2049
            4   O6a O    35.4556  -18.0091
            5   C2b C    31.7977  -16.8836
            6   C6a C    31.0942  -18.0091
            7   O6a O    29.7577  -18.0091
            8   O6a O    31.7977  -19.2049
            9   C8x C    19.9093  -17.0242
            10  C8y C    19.9093  -18.4311
            11  C8x C    21.1277  -19.1346
            12  C8x C    22.3462  -18.4311
            13  C8y C    22.3462  -17.0242
            14  C8x C    21.1277  -16.3208
            15  C8x C    24.7830  -18.4311
            16  C8y C    24.7830  -17.0242
            17  C1c C    23.5646  -16.3208
            18  C8x C    26.0014  -19.1346
            19  C8x C    27.2198  -18.4311
            20  C8x C    27.2198  -17.0242
            21  N5x N    26.0014  -16.3208
            22  X   Cl   18.6910  -19.1346
            23  O2a O    23.5646  -14.9139
            24  C1b C    24.7851  -14.2092
            25  C1b C    25.9875  -14.9036
            26  N1c N    27.1801  -14.2151
            27  C1a C    28.3775  -14.9066
            28  C1a C    27.1803  -12.8037
BOND        28
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     5   6 1
            6     6   7 1
            7     6   8 2
            8     9  10 2
            9    10  11 1
            10   11  12 2
            11   12  13 1
            12   13  14 2
            13    9  14 1
            14   15  16 1
            15   16  17 1
            16   13  17 1
            17   15  18 2
            18   18  19 1
            19   19  20 2
            20   20  21 1
            21   16  21 2
            22   10  22 1
            23   17  23 1
            24   23  24 1
            25   24  25 1
            26   25  26 1
            27   26  27 1
            28   26  28 1