| Entry |
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| Name | Naloxone hydrochloride (JP18/USP); Evzio (TN); Narcan (TN) | ||||||||||
| Product | EVZIO(R) NALOXONE HCL (HF Acquisition Co LLC), NARCAN (A-S Medication Solutions), NARCAN (Emergent Devices), NALOXONE HYDROCHLORIDE INJECTION, USP, AUTO-INJECTOR (Kaleo), NARCAN (Lake Erie Medical DBA Quality Care Products LLC), NARCAN (Proficient Rx LP), ZIMHI (USWM), NARCAN NALOXONE HCI (HF Acquisition Co LLC) | ||||||||||
| Generic | NALOXONE HCI (HF Acquisition Co. LLC), NALOXONE HYDROCHLORIDE (A-S Medication Solutions), NALOXONE HYDROCHLORIDE (A-S Medication Solutions), NALOXONE HYDROCHLORIDE (Akorn), NALOXONE HYDROCHLORIDE (AuroMedics Pharma LLC), NALOXONE HYDROCHLORIDE (AuroMedics Pharma LLC), NALOXONE HYDROCHLORIDE (AuroMedics Pharma LLC), NALOXONE HYDROCHLORIDE (Bryant Ranch Prepack), NALOXONE HYDROCHLORIDE (General Injectables & Vaccines), NALOXONE HYDROCHLORIDE (General Injectables & Vaccines), NALOXONE HYDROCHLORIDE (General Injectables & Vaccines), NALOXONE HYDROCHLORIDE (General Injectables and Vaccines), NALOXONE HYDROCHLORIDE (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co. LLC), NALOXONE HYDROCHLORIDE (HF Acquisition Co. LLC), NALOXONE HYDROCHLORIDE (Henry Schein), NALOXONE HYDROCHLORIDE (Henry Schein), NALOXONE HYDROCHLORIDE (Henry Schein), NALOXONE HYDROCHLORIDE (Henry Schein), NALOXONE HYDROCHLORIDE (Hikma Pharmaceuticals USA), NALOXONE HYDROCHLORIDE (Hospira), NALOXONE HYDROCHLORIDE (Hospira), NALOXONE HYDROCHLORIDE (International Medication Systems), NALOXONE HYDROCHLORIDE (International Medication Systems), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Mylan Institutional LLC), NALOXONE HYDROCHLORIDE (Padagis Israel Pharmaceuticals), NALOXONE HYDROCHLORIDE (Somerset Therapeutics), NALOXONE HYDROCHLORIDE (Somerset Therapeutics), NALOXONE HYDROCHLORIDE (A-S Medication Solutions), NALOXONE HYDROCHLORIDE (Sandoz), NALOXONE HYDROCHLORIDE (Civica), NALOXONE HYDROCHLORIDE (Hikma Pharmaceuticals USA), NALOXONE HYDROCHLORIDE (Hikma Pharmaceuticals USA), NALOXONE HYDROCHLORIDE (Medical Purchasing Solutions) | ||||||||||
| Formula | C19H21NO4. HCl | ||||||||||
| Exact mass | 363.1237 | ||||||||||
| Mol weight | 363.8353 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Analgesic DG01586 Opioid receptor antagonist | ||||||||||
| Remark |
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| Efficacy | Respiratory stimulant, Opioid receptor antagonist | ||||||||||
| Comment | Normorphine derivative | ||||||||||
| Target | OPRM1 [HSA:4988] [KO:K04215] OPRK1 [HSA:4986] [KO:K04214] OPRD1 [HSA:4985] [KO:K04213] | ||||||||||
| Pathway |
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| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] A ALIMENTARY TRACT AND METABOLISM A06 DRUGS FOR CONSTIPATION A06A DRUGS FOR CONSTIPATION A06AH Peripheral opioid receptor antagonist A06AH04 Naloxone D01340 Naloxone hydrochloride (JP18/USP) <JP/US> V VARIOUS V03 ALL OTHER THERAPEUTIC PRODUCTS V03A ALL OTHER THERAPEUTIC PRODUCTS V03AB Antidotes V03AB15 Naloxone D01340 Naloxone hydrochloride (JP18/USP) <JP/US> USP drug classification [BR:br08302] Anti-Addiction/Substance Abuse Treatment Agents Opioid Reversal Agents Naloxone D01340 Naloxone hydrochloride (JP18/USP) Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 22 Respiratory organ agents 221 Respiratory stimulants 2219 Others D01340 Naloxone hydrochloride (JP18/USP) Drug groups [BR:br08330] Analgesic DG01586 Opioid receptor antagonist DG01155 Naloxone D01340 Naloxone hydrochloride Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Opioid OPRM1 D01340 Naloxone hydrochloride (JP18/USP) <JP/US> OPRK1 D01340 Naloxone hydrochloride (JP18/USP) <JP/US> OPRD1 D01340 Naloxone hydrochloride (JP18/USP) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D01340 Naloxone hydrochloride Drug groups [BR:br08330] Analgesic DG01586 Opioid receptor antagonist DG01155 Naloxone | ||||||||||
| Other DBs |
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| KCF data | ATOM 25 1 X Cl 21.7908 -14.2119 2 C1z C 14.0948 -15.5899 3 C8y C 14.0948 -14.2668 4 C1z C 15.2786 -16.2861 5 C1y C 12.9806 -16.2166 6 C1x C 15.2786 -14.9632 7 C8y C 12.9806 -13.6401 8 C8y C 15.2786 -13.6401 9 C1y C 16.3927 -15.5899 10 C1x C 15.2786 -17.5396 11 O2x O 11.6576 -14.8934 12 C5x C 12.9806 -17.5396 13 C1x C 17.5068 -14.9632 14 C8y C 12.9806 -12.3171 15 C1x C 16.3927 -14.3364 16 C8x C 15.2786 -12.3171 17 N1y N 17.5068 -16.2861 18 C1x C 14.0948 -18.2359 19 O5x O 11.8665 -18.2359 20 C8x C 14.1644 -11.6904 21 O1a O 11.8665 -11.6904 22 O1a O 16.5319 -17.1914 23 C1b C 18.9047 -16.2861 24 C2b C 19.6072 -17.5026 25 C2a C 21.0000 -17.5025 BOND 28 1 2 3 1 2 2 4 1 3 2 5 1 4 2 6 1 #Up 5 3 7 2 6 3 8 1 7 4 9 1 8 4 10 1 9 5 11 1 #Down 10 5 12 1 11 6 13 1 12 7 14 1 13 8 15 1 14 8 16 2 15 9 17 1 #Up 16 10 18 1 17 12 19 2 18 14 20 2 19 14 21 1 20 7 11 1 21 9 15 1 22 12 18 1 23 13 17 1 24 16 20 1 25 4 22 1 #Up 26 17 23 1 27 23 24 1 28 24 25 2 |