| Entry |
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| Name | Erythromycin ethylsuccinate (JP18/USP); E.E.S. (TN); Eryped (TN); Erythrocin W (TN) | ||||||||||
| Product | ERY-PED (Arbor Pharmaceuticals), E.E.S (Arbor Pharmaceuticals), ERYTHROMYCIN ETHYLSUCCINATE (Bryant Ranch Prepack), ERYTHROMYCIN ETHYLSUCCINATE (Wilshire Pharmaceuticals), ERYTHROMYCIN ETHYLSUCCINATE (Wilshire Pharmaceuticals) | ||||||||||
| Generic | ERYTHROMYCIN ETHYLSUCCINATE (Amneal Pharmaceuticals NY LLC), ERYTHROMYCIN ETHYLSUCCINATE (ANI Pharmaceuticals), ERYTHROMYCIN ETHYLSUCCINATE (ANI Pharmaceuticals), ERYTHROMYCIN ETHYLSUCCINATE (Arbor Pharmaceuticals) | ||||||||||
| Formula | C43H75NO16 | ||||||||||
| Exact mass | 861.5086 | ||||||||||
| Mol weight | 862.0527 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Antibacterial DG01551 Macrolide antibiotic DG01874 14-membered ring macrolide antibiotic Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate Metabolizing enzyme inhibitor DG02852 CYP3A/CYP3A4 inhibitor Transporter inhibitor DG01622 ABCB1 inhibitor | ||||||||||
| Remark |
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| Efficacy | Antibacterial, Protein biosynthesis inhibitor | ||||||||||
| Disease | Listeriosis [DS:H00332] Pertussis [DS:H00319] Diphtheria [DS:H00343] Amebiasis [DS:H00360] Syphilis [DS:H00354] Legionnaires' disease [DS:H00311] | ||||||||||
| Comment | Active form of prodrug: Erythromycin [DR:D00140] | ||||||||||
| Target | 50S ribosomal subunit | ||||||||||
| Pathway |
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| Metabolism | Enzyme: CYP3A [HSA:1576 1577 1551] | ||||||||||
| Interaction | CYP inhibition: CYP3A [HSA:1576 1577 1551] Transporter inhibition: ABCB1 [HSA:5243] | ||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] D DERMATOLOGICALS D10 ANTI-ACNE PREPARATIONS D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE D10AF Antiinfectives for treatment of acne D10AF02 Erythromycin D01361 Erythromycin ethylsuccinate (JP18/USP) <JP/US> J ANTIINFECTIVES FOR SYSTEMIC USE J01 ANTIBACTERIALS FOR SYSTEMIC USE J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS J01FA Macrolides J01FA01 Erythromycin D01361 Erythromycin ethylsuccinate (JP18/USP) <JP/US> S SENSORY ORGANS S01 OPHTHALMOLOGICALS S01A ANTIINFECTIVES S01AA Antibiotics S01AA17 Erythromycin D01361 Erythromycin ethylsuccinate (JP18/USP) <JP/US> USP drug classification [BR:br08302] Antibacterials Macrolides Erythromycin D01361 Erythromycin ethylsuccinate (JP18/USP) Dermatological Agents Topical Anti-infectives Antibacterials, dermatological Erythromycin D01361 Erythromycin ethylsuccinate (JP18/USP) Ophthalmic Agents Ophthalmic Anti-Infectives Antibacterials, Ophthalmic Erythromycin D01361 Erythromycin ethylsuccinate (JP18/USP) Therapeutic category of drugs in Japan [BR:br08301] 6 Agents against pathologic organisms and parasites 61 Antibiotics 614 Acting mainly on gram-positive bacteria and mycoplasma 6141 Erythromycins D01361 Erythromycin ethylsuccinate (JP18/USP) Drug groups [BR:br08330] Antibacterial DG01551 Macrolide antibiotic DG01874 14-membered ring macrolide antibiotic DG00436 Erythromycin D01361 Erythromycin ethylsuccinate Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG00436 Erythromycin D01361 Erythromycin ethylsuccinate Metabolizing enzyme inhibitor DG02852 CYP3A/CYP3A4 inhibitor DG00436 Erythromycin D01361 Erythromycin ethylsuccinate Transporter inhibitor DG01622 ABCB1 inhibitor DG00436 Erythromycin D01361 Erythromycin ethylsuccinate Drug classes [BR:br08332] Antibacterial DG01551 Macrolide antibiotic D01361 Erythromycin ethylsuccinate Antimicrobials [BR:br08307] Antibacterials Protein biosynthesis inhibitor Macrolide D01361 Erythromycin ethylsuccinate (JP18/USP) <JP/US> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D01361 Erythromycin ethylsuccinate Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D01361 Drug transporters D01361 Prodrugs [br08324.html] D01361 Drug groups [BR:br08330] Antibacterial DG01551 Macrolide antibiotic DG01874 14-membered ring macrolide antibiotic DG00436 Erythromycin Metabolizing enzyme substrate DG01633 CYP3A/CYP3A4 substrate DG00436 Erythromycin Metabolizing enzyme inhibitor DG02852 CYP3A/CYP3A4 inhibitor DG00436 Erythromycin Transporter inhibitor DG01622 ABCB1 inhibitor DG00436 Erythromycin Antimicrobials abbreviations [BR:br08327] Antibacterials Protein biosynthesis inhibitor Macrolide DG00436 Erythromycin | ||||||||||
| Other DBs |
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| KCF data | ATOM 60 1 C1y C 26.6685 -9.4688 2 C1z C 26.6685 -8.1507 3 C1y C 25.5236 -10.1224 4 O2a O 29.1257 -10.4999 5 C1x C 25.5236 -7.4916 6 O1a O 27.6627 -7.1957 7 C1a C 27.9085 -8.5695 8 C1y C 25.5236 -11.4405 9 C1a C 24.5850 -9.1345 10 C1y C 30.3129 -7.8458 11 C1y C 25.5236 -6.1679 12 O2a O 26.2385 -12.7531 13 C1y C 24.3898 -12.0997 14 C1y C 31.4424 -8.5142 15 O2x O 30.3246 -6.5282 16 C5x C 24.3898 -5.5143 17 C1a C 26.6685 -5.5143 18 C1y C 27.7044 -13.1571 19 C7x C 23.2448 -11.4405 20 C1a C 24.3898 -13.4176 21 C1y C 32.6564 -7.8745 22 O7a O 31.5013 -10.6489 23 C1y C 31.4756 -5.8858 24 C1y C 23.2448 -6.1679 25 O5x O 24.3898 -4.1962 26 C1x C 27.7044 -14.4698 27 O2x O 28.8495 -12.4982 28 O7x O 23.2448 -10.1224 29 O6a O 22.2226 -12.3565 30 C1x C 32.6027 -6.5617 31 N1c N 33.7229 -8.5401 32 C1a C 31.4946 -4.5703 33 C1y C 23.2448 -7.4916 34 C1a C 22.1055 -5.5143 35 C1z C 28.8495 -15.1344 36 C1y C 29.9831 -13.1571 37 C1y C 22.1055 -9.4688 38 C1z C 22.1055 -8.1507 39 O1a O 24.3898 -8.1507 40 C1y C 29.9831 -14.4698 41 O2a O 28.8495 -16.4135 42 C1a C 30.2457 -16.0840 43 C1a C 31.1282 -12.5038 44 C1b C 20.9659 -10.1224 45 C1a C 20.8990 -8.6979 46 O1a O 20.8990 -7.4861 47 O1a O 31.1282 -15.1344 48 C1a C 29.9106 -17.3407 49 C1a C 20.9998 -11.2059 50 C1a C 34.9280 -7.8560 51 C7a C 32.6580 -11.3274 52 O6a O 32.6580 -12.6811 53 C1b C 33.7987 -10.6741 54 C1b C 34.9498 -11.3443 55 C1a C 33.7229 -9.8938 56 C7a C 36.1516 -10.6561 57 O7a O 37.3309 -11.3426 58 O6a O 36.0870 -9.2405 59 C1b C 38.5311 -10.6552 60 C1a C 39.7112 -11.3421 BOND 62 1 1 2 1 2 1 3 1 3 1 4 1 #Down 4 2 5 1 5 2 6 1 #Up 6 2 7 1 #Down 7 3 8 1 8 3 9 1 #Down 9 10 4 1 #Down 10 5 11 1 11 8 12 1 #Down 12 8 13 1 13 10 14 1 14 10 15 1 15 11 16 1 16 11 17 1 #Down 17 18 12 1 #Down 18 13 19 1 19 13 20 1 #Up 20 14 21 1 21 14 22 1 #Up 22 15 23 1 23 16 24 1 24 16 25 2 25 18 26 1 26 18 27 1 27 19 28 1 28 19 29 2 29 21 30 1 30 21 31 1 #Down 31 23 32 1 #Down 32 24 33 1 33 24 34 1 #Up 34 26 35 1 35 27 36 1 36 28 37 1 37 33 38 1 38 33 39 1 #Up 39 35 40 1 40 35 41 1 #Down 41 35 42 1 42 36 43 1 #Up 43 37 44 1 #Down 44 38 45 1 #Down 45 38 46 1 #Up 46 40 47 1 #Down 47 41 48 1 48 44 49 1 49 23 30 1 50 36 40 1 51 37 38 1 52 31 50 1 53 22 51 1 54 51 52 2 55 51 53 1 56 53 54 1 57 31 55 1 58 54 56 1 59 56 57 1 60 56 58 2 61 57 59 1 62 59 60 1 |