| Entry |
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| Name | Ebastine (JP18/USAN/INN); Kestine (TN) | ||||||||||
| Formula | C32H39NO2 | ||||||||||
| Exact mass | 469.2981 | ||||||||||
| Mol weight | 469.6576 | ||||||||||
| Structure |  | ||||||||||
| Class | Anti-allergic agent DG01557 Histamine receptor antagonist DG01482 Histamine receptor H1 antagonist Metabolizing enzyme substrate DG02954 CYP2J2 substrate DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate | ||||||||||
| Remark |
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| Efficacy | Antiallergic, Antipruritic, H1 receptor antagonist | ||||||||||
| Target | HRH1 [HSA:3269] [KO:K04149] | ||||||||||
| Pathway |
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| Metabolism | Enzyme: CYP2J2 [HSA:1573], CYP3A4 [HSA:1576] | ||||||||||
| Interaction | |||||||||||
| Structure map |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] R RESPIRATORY SYSTEM R06 ANTIHISTAMINES FOR SYSTEMIC USE R06A ANTIHISTAMINES FOR SYSTEMIC USE R06AX Other antihistamines for systemic use R06AX22 Ebastine D01478 Ebastine (JP18/USAN/INN) <JP> Therapeutic category of drugs in Japan [BR:br08301] 4 Agents affecting cellular function 44 Allergic agents 449 Miscellaneous 4490 Miscellaneous D01478 Ebastine (JP18/USAN/INN) Classification of Japanese OTC drugs [BR:br08313] Agents for otolaryngologic use 69 Oral medicine for nasal inflammation D01478 Ebastine (JP18/USAN/INN) Risk category of Japanese OTC drugs [BR:br08312] Second-class OTC drugs Inorganic and organic chemicals Ebastine D01478 Ebastine (JP18/USAN/INN) Drug groups [BR:br08330] Anti-allergic agent DG01557 Histamine receptor antagonist DG01482 Histamine receptor H1 antagonist D01478 Ebastine Metabolizing enzyme substrate DG02954 CYP2J2 substrate D01478 Ebastine DG01633 CYP3A/CYP3A4 substrate DG02913 CYP3A4 substrate D01478 Ebastine Drug classes [BR:br08332] Anti-allergic agent DG01482 Histamine receptor H1 antagonist D01478 Ebastine Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Histamine HRH1 D01478 Ebastine (JP18/USAN/INN) <JP> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D01478 Ebastine D01478 Ebastine tablets D01478 Ebastine orally disintegrating tablets Drug metabolizing enzymes and transporters [br08309.html] Drug metabolizing enzymes D01478 Rx-to-OTC switch list in Japan [br08314.html] D01478 | ||||||||||
| Other DBs |
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| KCF data | ATOM 35 1 C8y C 34.2938 -13.6276 2 C8x C 35.5095 -14.3273 3 C8x C 36.7234 -13.6244 4 C8y C 36.7215 -12.2217 5 C8x C 35.5058 -11.5220 6 C8x C 34.2919 -12.2249 7 C1d C 37.9408 -11.5356 8 C8x C 20.9617 -18.5185 9 C8x C 20.9617 -19.9179 10 C8x C 22.1765 -20.6176 11 C8x C 23.3843 -19.9179 12 C8y C 23.3843 -18.5185 13 C8x C 22.1765 -17.8188 14 C1c C 24.5968 -17.8196 15 C8y C 25.8081 -18.5204 16 O2a O 24.5978 -16.4202 17 C8x C 25.8017 -19.9178 18 C8x C 27.0130 -20.6183 19 C8x C 28.2255 -19.9196 20 C8x C 28.2265 -18.5202 21 C8x C 27.0150 -17.8195 22 C1y C 25.8103 -15.7215 23 C1x C 27.0199 -16.4210 24 C1x C 28.2324 -15.7223 25 N1y N 28.2335 -14.3229 26 C1x C 27.0220 -13.6222 27 C1x C 25.8096 -14.3210 28 C1b C 29.4460 -13.6240 29 C1b C 30.6574 -14.3246 30 C1b C 31.8700 -13.6259 31 C5a C 33.0813 -14.3265 32 O5a O 33.0802 -15.7259 33 C1a C 39.1533 -10.8356 34 C1a C 38.6402 -12.7623 35 C1a C 37.2535 -10.3299 BOND 38 1 5 6 1 2 6 1 2 3 4 7 1 4 1 2 1 5 11 12 1 6 12 13 2 7 13 8 1 8 15 17 2 9 17 18 1 10 18 19 2 11 19 20 1 12 20 21 2 13 21 15 1 14 16 22 1 15 12 14 1 16 14 15 1 17 8 9 2 18 14 16 1 19 22 23 1 20 23 24 1 21 24 25 1 22 25 26 1 23 26 27 1 24 27 22 1 25 9 10 1 26 25 28 1 27 10 11 2 28 28 29 1 29 29 30 1 30 2 3 2 31 30 31 1 32 31 1 1 33 3 4 1 34 31 32 2 35 4 5 2 36 7 33 1 37 7 34 1 38 7 35 1 |