Lormetazepam


Entry
D01657                      Drug                                   
Name
Lormetazepam (JAN/USAN/INN);
Loramet (TN)
Formula
C16H12Cl2N2O2
Exact mass
334.0276
Mol weight
335.1847
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG03202  Hypnotic
 DG01567  GABA-A receptor agonist
Remark
Therapeutic category: 1124
ATC code: N05CD06
Product: D01657<JP>
Efficacy
Sedative-hypnotic
Comment
Benzodiazepine derivative
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Structure map
map07030  Anxiolytics
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD06 Lormetazepam
      D01657  Lormetazepam (JAN/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01657  Lormetazepam (JAN/USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01835  Benzodiazepine sedative-hypnotics
   D01657  Lormetazepam
  DG03202  Hypnotic
   D01657  Lormetazepam
  DG01567  GABA-A receptor agonist
   D01657  Lormetazepam
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03202  Hypnotic
   D01657  Lormetazepam
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D01657  Lormetazepam (JAN/USAN/INN) <JP>
Other DBs
CAS: 848-75-9
PubChem: 7848720
ChEBI: 52993
LigandBox: D01657
NIKKAJI: J7.142K
KCF data

ATOM        22
            1   C2y C    15.6571  -18.0408
            2   C8y C    14.8125  -16.9281
            3   C8y C    15.1487  -15.5674
            4   N1y N    16.4133  -14.9876
            5   N2x N    17.0669  -18.0661
            6   C5x C    17.6705  -15.6117
            7   C1y C    17.9578  -16.9843
            8   C8x C    14.1387  -14.5962
            9   C8x C    12.7928  -14.9854
            10  C8y C    12.4567  -16.3461
            11  C8x C    13.4667  -17.3170
            12  O1a O    19.2928  -17.4227
            13  O5x O    18.7176  -14.6746
            14  X   Cl   11.1039  -16.7371
            15  C8y C    14.9355  -19.2403
            16  C8x C    13.5358  -19.2403
            17  C8x C    12.8359  -20.4525
            18  C8x C    13.5358  -21.6648
            19  C8x C    14.9355  -21.6648
            20  C8y C    15.6354  -20.4525
            21  X   Cl   17.0059  -20.4522
            22  C1a C    16.3652  -13.5811
BOND        24
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 1
            14    6  13 2
            15   10  14 1
            16    1  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   15  20 2
            23   20  21 1
            24    4  22 1