Darifenacin hydrobromide

Entry

D01699                      Drug

Name

Darifenacin hydrobromide (JAN/USAN);
Enablex (TN)

Product

Generic

DARIFENACIN (Alembic Pharmaceuticals), DARIFENACIN (Alembic Pharmaceuticals Limited), DARIFENACIN (Aurobindo Pharma Limited), DARIFENACIN (Macleods Pharmaceuticals Limited), DARIFENACIN (Rising Pharma Holdings), DARIFENACIN (Torrent Pharmaceuticals Limited), DARIFENACIN (Cipla USA), DARIFENACIN (Polygen Pharmaceuticals), DARIFENACIN HYDROBROMIDE (Proficient Rx LP), DARIFENACIN HYDROBROMIDE (Xiromed)

Formula

C28H30N2O2. HBr

Exact mass

506.1569

Mol weight

507.4619

Structure

Simcomp

Class

Neuropsychiatric agent
DG01491  Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
DG01644  CYP2D6 substrate
DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate

Remark

ATC code:

G04BD10

Chemical structure group:

DG00482

Product (DG00482):

D01699<US>

Efficacy

Overactive bladder agent, Muscarinic acetylcholine receptor antagonist

Target

CHRM3 [HSA:1131] [KO:K04131]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04725

Cholinergic synapse

Metabolism

Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD10 Darifenacin
      D01699  Darifenacin hydrobromide (JAN/USAN) <US>
USP drug classification [BR:br08302]
Genitourinary Agents
  Antispasmodics, Urinary
   Darifenacin
    D01699  Darifenacin hydrobromide (JAN/USAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00482  Darifenacin
    D01699  Darifenacin hydrobromide
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00482  Darifenacin
    D01699  Darifenacin hydrobromide
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00482  Darifenacin
     D01699  Darifenacin hydrobromide
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM3
     D01699  Darifenacin hydrobromide (JAN/USAN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D01699
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D01699
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D01699
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D01699
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D01699
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01491  Muscarinic cholinergic receptor antagonist
   DG00482  Darifenacin
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00482  Darifenacin
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00482  Darifenacin

Other DBs

CAS:	133099-07-7

PubChem:

7848762

ChEBI:

31455

LigandBox:

D01699

KCF data

ATOM        33
            1   X   Br   23.8000  -21.2800
            2   C1x C    14.9100  -22.2600
            3   C1x C    16.3100  -22.2600
            4   C1y C    16.7426  -20.9285
            5   C1x C    15.6100  -20.1056
            6   N1y N    14.4774  -20.9285
            7   C1b C    13.2776  -20.2300
            8   C1b C    12.0651  -20.9300
            9   C8y C    10.8527  -20.2300
            10  C8x C     9.6403  -20.9300
            11  C8y C     8.4278  -20.2300
            12  C1d C    17.9424  -20.2300
            13  C8y C    19.1549  -20.9300
            14  C8y C    17.9399  -18.8301
            15  C8x C    19.1361  -18.1365
            16  C8x C    19.1335  -16.7365
            17  C8x C    17.9197  -16.0388
            18  C8x C    16.7235  -16.7324
            19  C8x C    16.7261  -18.1324
            20  C8x C    19.1549  -22.3300
            21  C8x C    20.3673  -23.0300
            22  C8x C    21.5797  -22.3300
            23  C8x C    21.5797  -20.9300
            24  C8x C    20.3673  -20.2300
            25  C8x C    10.8527  -18.8300
            26  C8x C     9.6403  -18.1300
            27  C8y C     8.4278  -18.8300
            28  O2x O     7.0963  -18.3974
            29  C1x C     6.2734  -19.5300
            30  C1x C     7.0963  -20.6626
            31  C5a C    20.9749  -18.6200
            32  O5a O    22.1796  -19.3741
            33  N1a N    21.0247  -17.2202
BOND        36
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     2   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11    4  12 1 #Down
            12   12  13 1
            13   12  14 1
            14   14  15 1
            15   15  16 2
            16   16  17 1
            17   17  18 2
            18   18  19 1
            19   14  19 2
            20   13  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   13  24 1
            26    9  25 1
            27   25  26 2
            28   26  27 1
            29   27  11 2
            30   27  28 1
            31   28  29 1
            32   29  30 1
            33   11  30 1
            34   12  31 1
            35   31  32 2
            36   31  33 1