Isoxsuprine hydrochloride


Entry
D01748                      Drug                                   
Name
Isoxsuprine hydrochloride (JP18/USP);
Duvadilan (TN)
Formula
C18H23NO3. HCl
Exact mass
337.1445
Mol weight
337.8411
Structure
Simcomp
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01455  beta-Adrenergic receptor agonist
   DG01452  beta2-Adrenergic receptor agonist
Remark
Therapeutic category: 1249 2172
ATC code: C04AA01
Chemical structure group: DG00277
Product (DG00277): D01748<JP>
Efficacy
Vasodilator, beta2-Adrenergic receptor agonist
  Disease
Arteriosclerosis obliterans [DS:H01626]
Thromboangiitis obliterans; Buerger's disease [DS:H01625]
Raynaud's disease [DS:H01620]
Target
ADRB2 [HSA:154] [KO:K04142]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C04 PERIPHERAL VASODILATORS
   C04A PERIPHERAL VASODILATORS
    C04AA 2-amino-1-phenylethanol derivatives
     C04AA01 Isoxsuprine
      D01748  Isoxsuprine hydrochloride (JP18/USP) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   124  Antispasmodics
    1249  Others
     D01748  Isoxsuprine hydrochloride (JP18/USP)
 2  Agents affecting individual organs
  21  Cardiovascular agents
   217  Vasodilators
    2172  Peripheral artery dilators
     D01748  Isoxsuprine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01455  beta-Adrenergic receptor agonist
    DG01452  beta2-Adrenergic receptor agonist
     DG00277  Isoxsuprine
      D01748  Isoxsuprine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB2
     D01748  Isoxsuprine hydrochloride (JP18/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01748  Isoxsuprine hydrochloride
  D01748  Isoxsuprine hydrochloride tablets
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01456  Adrenergic receptor agonist
   DG01455  beta-Adrenergic receptor agonist
    DG01452  beta2-Adrenergic receptor agonist
     DG00277  Isoxsuprine
Other DBs
CAS: 579-56-6
PubChem: 7848811
ChEBI: 31735
LigandBox: D01748
NIKKAJI: J529.160G
KCF data

ATOM        23
            1   C8y C    17.0800  -15.8200
            2   C1c C    18.3400  -16.5200
            3   C1c C    19.5300  -15.8200
            4   N1b N    20.7200  -16.5200
            5   C1c C    21.9800  -15.8200
            6   C1b C    23.1700  -16.5200
            7   O2a O    24.3600  -15.8200
            8   C1a C    19.5300  -14.4200
            9   C1a C    21.9800  -14.4200
            10  C8y C    25.6200  -16.5200
            11  C8x C    25.6200  -17.9200
            12  C8x C    26.8100  -18.6200
            13  C8x C    28.0000  -17.9200
            14  C8x C    28.0000  -16.5200
            15  C8x C    26.8100  -15.8200
            16  O1a O    18.3400  -17.9200
            17  C8x C    17.0800  -14.4900
            18  C8x C    15.8900  -13.7900
            19  C8y C    14.7000  -14.4900
            20  C8x C    14.7000  -15.8900
            21  C8x C    15.8900  -16.5900
            22  O1a O    13.4400  -13.7900
            23  X   Cl   30.8000  -17.0800
BOND        23
            1     5   6 1
            2     2   3 1
            3     6   7 1
            4    10  11 2
            5    11  12 1
            6    12  13 2
            7    13  14 1
            8    14  15 2
            9    15  10 1
            10    2  16 1
            11    3   8 1
            12    3   4 1
            13    5   9 1
            14    1   2 1
            15    7  10 1
            16    1  17 2
            17   17  18 1
            18   18  19 2
            19   19  20 1
            20   20  21 2
            21   21   1 1
            22    4   5 1
            23   19  22 1