| Entry |
| ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Name | Diflucortolone valerate (JP18); Afusona (TN) | ||||||||||
| Formula | C27H36F2O5 | ||||||||||
| Exact mass | 478.2531 | ||||||||||
| Mol weight | 478.5685 | ||||||||||
| Structure |  | ||||||||||
| Simcomp | |||||||||||
| Class | Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid | ||||||||||
| Remark |
| ||||||||||
| Efficacy | Anti-inflammatory, Glucocorticoid receptor agonist | ||||||||||
| Target | NR3C1 (GR) [HSA:2908] [KO:K05771] | ||||||||||
| Pathway |
| ||||||||||
| Interaction | |||||||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] D DERMATOLOGICALS D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS D07A CORTICOSTEROIDS, PLAIN D07AC Corticosteroids, potent (group III) D07AC06 Diflucortolone D01764 Diflucortolone valerate (JP18) <JP> D07X CORTICOSTEROIDS, OTHER COMBINATIONS D07XC Corticosteroids, potent, other combinations D07XC04 Diflucortolone D01764 Diflucortolone valerate (JP18) <JP> Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 26 Epidermides 264 Analgesics, anti-itchings, astringents, anti-inflammatory agents 2646 Adrenocorticotropic hormones D01764 Diflucortolone valerate (JP18) Drug groups [BR:br08330] Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid DG00417 Diflucortolone D01764 Diflucortolone valerate Drug classes [BR:br08332] Anti-inflammatory DG01955 Corticosteroid D01764 Diflucortolone valerate Target-based classification of drugs [BR:br08310] Nuclear receptors Estrogen like receptors 3-Ketosteroid receptor NR3C1 (GR) D01764 Diflucortolone valerate (JP18) <JP> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D01764 Diflucortolone valerate Topical steroids potency [br08317.html] Classification in Japan D01764 Drug groups [BR:br08330] Anti-inflammatory DG01955 Corticosteroid DG02068 Glucocorticoid DG00417 Diflucortolone | ||||||||||
| Other DBs |
| ||||||||||
| KCF data | ATOM 34 1 C1b C 31.8654 -12.1970 2 O7a O 30.7091 -12.8841 3 C7a C 29.5392 -12.2312 4 C1b C 28.3829 -12.9181 5 O6a O 29.5211 -10.8846 6 C5a C 33.0353 -12.8500 7 C2x C 26.0133 -17.3146 8 C5x C 26.0133 -18.6613 9 C2x C 27.1823 -19.3347 10 C2x C 27.1823 -16.6413 11 C1z C 28.3446 -17.3146 12 C2y C 28.3387 -18.6613 13 C1y C 29.5022 -19.3398 14 C1x C 30.6714 -18.6713 15 C1z C 29.5138 -16.6464 16 C1y C 30.6714 -17.3275 17 C1x C 30.6935 -14.6412 18 C1y C 29.5247 -15.3033 19 C1z C 31.8512 -15.3221 20 C1y C 31.8351 -16.6614 21 C1x C 34.1542 -16.6895 22 C1y C 34.1706 -15.3504 23 C1y C 33.0189 -14.6668 24 C1a C 31.8422 -13.9751 25 O1a O 28.3641 -14.6202 26 C1a C 28.3325 -15.9679 27 C1a C 35.3449 -14.6911 28 X F 29.5026 -17.9880 29 X F 29.4887 -20.6814 30 O5x O 24.8473 -19.3354 31 O5a O 34.2023 -12.1923 32 C1b C 27.1512 -12.2268 33 C1b C 25.9439 -12.9435 34 C1a C 24.7458 -12.2709 BOND 37 1 3 4 1 2 1 2 1 3 6 1 1 4 15 16 1 5 16 20 1 6 19 17 1 7 17 18 1 8 18 15 1 9 7 8 1 10 8 9 1 11 9 12 2 12 11 10 1 13 19 20 1 14 21 22 1 15 22 23 1 16 23 19 1 17 20 21 1 18 23 6 1 #Up 19 10 7 2 20 19 24 1 #Up 21 2 3 1 22 3 5 2 23 18 25 1 #Up 24 11 26 1 #Up 25 22 27 1 #Down 26 11 12 1 27 12 13 1 28 15 28 1 #Down 29 13 14 1 30 13 29 1 #Down 31 14 16 1 32 8 30 2 33 15 11 1 34 6 31 2 35 4 32 1 36 32 33 1 37 33 34 1 |