Bromhexine hydrochloride


Entry
D01778                      Drug                                   
Name
Bromhexine hydrochloride (JP18/USAN);
Bisolvon (TN)
Formula
C14H20Br2N2. HCl
Exact mass
409.976
Mol weight
412.5909
Structure
Simcomp
Remark
Therapeutic category: 2234
ATC code: R05CB02
Chemical structure group: DG01070
Product (DG01070): D01778<JP>
Efficacy
Expectorant, Mucolytic
Comment
Bromhexine derivative
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R05 COUGH AND COLD PREPARATIONS
   R05C EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS
    R05CB Mucolytics
     R05CB02 Bromhexine
      D01778  Bromhexine hydrochloride (JP18/USAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   223  Expectorants
    2234  Bromhexines
     D01778  Bromhexine hydrochloride (JP18/USAN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for respiratory organs
  26 Antitussives and expectorants
   D01778  Bromhexine hydrochloride (JP18/USAN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Bromhexine
    D01778  Bromhexine hydrochloride (JP18/USAN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01778  Bromhexine hydrochloride
Rx-to-OTC switch list in Japan [br08314.html]
 D01778
Other DBs
CAS: 611-75-6
PubChem: 7848840
ChEBI: 31303
LigandBox: D01778
NIKKAJI: J402.609H
KCF data

ATOM        19
            1   X   Cl   33.5857  -19.6940
            2   C8y C    22.6800  -17.9900
            3   C8x C    22.6800  -19.3900
            4   C8y C    23.9400  -20.0900
            5   C8y C    25.1300  -19.3900
            6   C8y C    25.1300  -17.9900
            7   C8x C    23.9400  -17.2900
            8   N1a N    26.3900  -20.0900
            9   X   Br   23.9400  -21.4900
            10  X   Br   21.4900  -17.2900
            11  C1b C    26.3900  -17.2900
            12  N1c N    27.5800  -17.9900
            13  C1y C    28.7700  -17.2900
            14  C1x C    29.9600  -17.9900
            15  C1x C    31.1500  -17.2900
            16  C1x C    31.1500  -15.8900
            17  C1x C    29.9600  -15.1900
            18  C1x C    28.7700  -15.8900
            19  C1a C    27.5800  -19.3900
BOND        19
            1     2   3 1
            2     3   4 2
            3     4   5 1
            4     5   6 2
            5     6   7 1
            6     2   7 2
            7     5   8 1
            8     4   9 1
            9     2  10 1
            10    6  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   13  18 1
            19   12  19 1