Triprolidine hydrochloride


Entry
D01782                      Drug                                   
Name
Triprolidine hydrochloride (USP);
Triprolidine hydrochloride hydrate (JAN);
Venen (TN)
Formula
C19H22N2. HCl. H2O
Exact mass
332.1655
Mol weight
332.8676
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Remark
ATC code: R06AX07
Chemical structure group: DG01111
Efficacy
Antiallergic, Antipruritic, H1 receptor antagonist
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX07 Triprolidine
      D01782  Triprolidine hydrochloride (USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D01782  Triprolidine hydrochloride (USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Triprolidine
    D01782  Triprolidine hydrochloride (USP)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01111  Triprolidine
     D01782  Triprolidine hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D01782  Triprolidine hydrochloride (USP)
Rx-to-OTC switch list in the USA [br08315.html]
 D01782
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01111  Triprolidine
Other DBs
CAS: 6138-79-0
PubChem: 7848844
ChEBI: 32265
LigandBox: D01782
NIKKAJI: J1.591.795D
KCF data

ATOM        23
            1   X   Cl   29.7575  -15.7912
            2   C2b C    23.9165  -17.9663
            3   C1b C    22.7028  -17.2667
            4   N1y N    22.7018  -15.8660
            5   C1x C    21.5661  -15.0520
            6   C1x C    21.9980  -13.7193
            7   C1x C    23.3986  -13.7185
            8   C1x C    23.8326  -15.0503
            9   C8x C    20.2769  -20.0664
            10  C8y C    20.2769  -21.4672
            11  C8x C    21.4929  -22.1676
            12  C8x C    22.7018  -21.4672
            13  C8y C    22.7018  -20.0664
            14  C8x C    21.4929  -19.3660
            15  C2c C    23.9153  -19.3671
            16  C8y C    25.1280  -20.0683
            17  C8x C    25.1213  -21.4670
            18  C8x C    26.3340  -22.1684
            19  C8x C    27.5477  -21.4689
            20  C8x C    27.5487  -20.0681
            21  N5x N    26.3360  -19.3669
            22  C1a C    19.0641  -22.1683
            23  O0  O    30.1596  -17.6328
BOND        23
            1     4   5 1
            2     9  10 2
            3    10  11 1
            4    11  12 2
            5    12  13 1
            6    13  14 2
            7    14   9 1
            8     5   6 1
            9    13  15 1
            10    6   7 1
            11   15  16 1
            12    7   8 1
            13    8   4 1
            14    3   4 1
            15   16  17 2
            16   17  18 1
            17   18  19 2
            18   19  20 1
            19   20  21 2
            20   21  16 1
            21    2   3 1
            22   10  22 1
            23   15   2 2