Ufenamate

Entry

D01823                      Drug

Name

Ufenamate (JAN/INN);
Flufenamic acid butyl ester;
Combec (TN)

Formula

C18H18F3NO2

Exact mass

337.129

Mol weight

337.3362

Structure

Simcomp

Class

Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01911 Anti-inflammatory drug, fenamic acid derivatives

Remark

Therapeutic category:

2649

ATC code:

M01AG03

Chemical structure group:

DG00757

Product (DG00757):

D01823<JP> D03254<JP>

Efficacy

Analgesic, Anti-inflammatory (topical), COX inhibitor

Comment

Fenamic acid derivative

Target

PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]

Pathway

hsa00590

Arachidonic acid metabolism

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AG Fenamates
     M01AG03 Flufenamic acid
      D01823  Ufenamate (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D01823  Ufenamate (JAN/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D01823  Ufenamate (JAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
  Inorganic and organic chemicals
   Ufenamate
    D01823  Ufenamate (JAN/INN)
Drug groups [BR:br08330]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01911  Anti-inflammatory drug, fenamic acid derivatives
    DG00757  Flufenamic acid
     D01823  Ufenamate
Drug classes [BR:br08332]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D01823  Ufenamate
Target-based classification of drugs [BR:br08310]
Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D01823  Ufenamate (JAN/INN) <JP>
    PTGS2 (COX2)
     D01823  Ufenamate (JAN/INN) <JP>
Rx-to-OTC switch list in Japan [br08314.html]
D01823
Drug groups [BR:br08330]
Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01911  Anti-inflammatory drug, fenamic acid derivatives
    DG00757  Flufenamic acid

Other DBs

CAS:	67330-25-0

PubChem:

7848885

ChEBI:

32276

LigandBox:

D01823

NIKKAJI:

J22.205D

KCF data

ATOM        24
            1   C8x C    11.6200  -22.0500
            2   C8x C    11.6200  -23.4500
            3   C8x C    12.8800  -24.2200
            4   C8x C    14.0700  -23.4500
            5   C8y C    14.0700  -22.0500
            6   C8y C    12.8800  -21.3500
            7   C8x C    16.5200  -23.4500
            8   C8y C    16.5200  -22.0500
            9   N1b N    15.2600  -21.3500
            10  C8x C    17.7100  -24.2200
            11  C8x C    18.9000  -23.4500
            12  C8y C    18.9000  -22.0500
            13  C8x C    17.7100  -21.3500
            14  C7a C    12.8800  -19.9500
            15  O6a O    11.6200  -19.2500
            16  O7a O    14.0700  -19.2500
            17  C1b C    14.0700  -17.8500
            18  C1b C    15.2824  -17.1500
            19  C1b C    16.4779  -17.8404
            20  C1a C    17.6653  -17.1549
            21  C1d C    20.1153  -21.3549
            22  X   F    19.4153  -20.1425
            23  X   F    20.8153  -22.5674
            24  X   F    21.3277  -20.6549
BOND        25
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 2
            8     8   9 1
            9     5   9 1
            10    7  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    6  14 1
            16   14  15 2
            17   14  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   12  21 1
            23   21  22 1
            24   21  23 1
            25   21  24 1