Eptazocine hydrobromide

Entry

D01879                      Drug

Name

Eptazocine hydrobromide (JAN);
Sedapain (TN)

Formula

C15H21NO. HBr

Exact mass

311.0885

Mol weight

312.2453

Structure

Simcomp

Class

Neuropsychiatric agent
DG01564  Opioid receptor agonist
  DG01562  kappa-Opioid receptor agonist
Analgesic
DG01984  Opioid analgesics
DG01586  Opioid receptor antagonist

Remark

Therapeutic category:

1149

Chemical structure group:

DG01340

Efficacy

Analgesic, Opioid receptor agonist/antagonist

Comment

Benzomorphan derivative

Target

OPRK1 [HSA:4986] [KO:K04214]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

Interaction

Structure map

map07224

Opioid receptor agonists/antagonists

Brite

Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D01879  Eptazocine hydrobromide (JAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01562  kappa-Opioid receptor agonist
    DG01340  Eptazocine
     D01879  Eptazocine hydrobromide
Analgesic
  DG01984  Opioid analgesics
   DG01340  Eptazocine
    D01879  Eptazocine hydrobromide
  DG01586  Opioid receptor antagonist
   DG01340  Eptazocine
    D01879  Eptazocine hydrobromide
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRK1
     D01879  Eptazocine hydrobromide (JAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG01564  Opioid receptor agonist
   DG01562  kappa-Opioid receptor agonist
    DG01340  Eptazocine
Analgesic
  DG01984  Opioid analgesics
   DG01340  Eptazocine
  DG01586  Opioid receptor antagonist
   DG01340  Eptazocine

Other DBs

CAS:	72150-17-5

PubChem:

7848941

ChEBI:

31553

LigandBox:

D01879

NIKKAJI:

J358.594H

KCF data

ATOM        18
            1   X   Br   23.8750  -20.2320
            2   C1z C    19.9500  -23.3100
            3   C8y C    19.9500  -21.9800
            4   C1x C    21.2100  -24.0100
            5   C1a C    18.8300  -23.9400
            6   C1x C    21.2100  -22.6800
            7   C8x C    18.8300  -21.3500
            8   C8y C    21.2100  -21.3500
            9   C1y C    22.3300  -23.3100
            10  C8y C    18.8300  -20.0200
            11  C1x C    22.3300  -22.0500
            12  C8x C    21.2100  -20.0200
            13  C8x C    20.0200  -19.3200
            14  O1a O    17.7100  -19.3200
            15  C1x C    23.5545  -23.9887
            16  N1y N    24.9545  -23.9887
            17  C1x C    24.9545  -22.6587
            18  C1a C    25.9373  -24.9718
BOND        19
            1     2   3 1
            2     2   4 1
            3     2   5 1
            4     2   6 1 #Up
            5     3   7 2
            6     3   8 1
            7     4   9 1
            8     7  10 1
            9     8  11 1
            10    8  12 2
            11   10  13 2
            12   10  14 1
            13    9  11 1
            14   12  13 1
            15    9  15 1 #Up
            16   15  16 1
            17   16  17 1
            18   17   6 1
            19   16  18 1