Rosuvastatin calcium


Entry
D01915                      Drug                                   
Name
Rosuvastatin calcium (JP18/USP);
ZD 4522;
Crestor (TN)
Product
EZALLOR SPRINKLE (Sun Pharmaceutical Industries), CRESTOR (A-S Medication Solutions), CRESTOR (AstraZeneca Pharmaceuticals LP), CRESTOR (AstraZeneca Pharmaceuticals LP), CRESTOR (Bryant Ranch Prepack), CRESTOR (Bryant Ranch Prepack)
  Generic
ROSUVASTATIN (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN (A-S Medication Solutions), ROSUVASTATIN (Accord Healthcare), ROSUVASTATIN (Amneal Pharmaceuticals NY LLC), ROSUVASTATIN (AvPAK), ROSUVASTATIN (Bryant Ranch Prepack), ROSUVASTATIN (Bryant Ranch Prepack), ROSUVASTATIN (Bryant Ranch Prepack), ROSUVASTATIN (Camber Pharmaceuticals), ROSUVASTATIN (DIRECT RX), ROSUVASTATIN (Direct_Rx), ROSUVASTATIN (NuCare Pharmaceuticals), ROSUVASTATIN (NuCare Pharmaceuticals), ROSUVASTATIN (Preferred Pharmaceuticals), ROSUVASTATIN (Preferred Pharmaceuticals), ROSUVASTATIN (Proficient Rx LP), ROSUVASTATIN (Quality Care Products), ROSUVASTATIN (Quality Care Products), ROSUVASTATIN (REMEDYREPACK), ROSUVASTATIN (REMEDYREPACK), ROSUVASTATIN (ScieGen Pharmaceuticals), ROSUVASTATIN (Zydus Lifesciences Limited), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (A-S Medication Solutions), ROSUVASTATIN CALCIUM (American Health Packaging), ROSUVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ROSUVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ROSUVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ROSUVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ROSUVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ROSUVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ROSUVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ROSUVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ROSUVASTATIN CALCIUM (Ascend Laboratories), ROSUVASTATIN CALCIUM (Aurobindo Pharma Limited), ROSUVASTATIN CALCIUM (Biocon Pharma), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Bryant Ranch Prepack), ROSUVASTATIN CALCIUM (Cadila Pharmaceuticals Limited), ROSUVASTATIN CALCIUM (Cardinal Health), ROSUVASTATIN CALCIUM (Denton Pharma), ROSUVASTATIN CALCIUM (Denton Pharma), ROSUVASTATIN CALCIUM (EMC PHARMA), ROSUVASTATIN CALCIUM (Glenmark Pharmaceutials), ROSUVASTATIN CALCIUM (Golden State Medical Supply), ROSUVASTATIN CALCIUM (Jubilant Cadista Pharmaceuticals), ROSUVASTATIN CALCIUM (MSN LABORATORIES PRIVATE LIMITED), ROSUVASTATIN CALCIUM (Major Pharmaceuticals), ROSUVASTATIN CALCIUM (NorthStar RxLLC), ROSUVASTATIN CALCIUM (Northwind Pharmaceuticals), ROSUVASTATIN CALCIUM (Novadoz Pharmaceuticals LLC), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (NuCare Pharmaceuticals), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals), ROSUVASTATIN CALCIUM (Preferred Pharmaceuticals), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (Proficient Rx LP), ROSUVASTATIN CALCIUM (QUALLENT), ROSUVASTATIN CALCIUM (Quality Care Products), ROSUVASTATIN CALCIUM (Quality Care Products), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (REMEDYREPACK), ROSUVASTATIN CALCIUM (Rising Health), ROSUVASTATIN CALCIUM (Sandoz), ROSUVASTATIN CALCIUM (Shandong New Time Pharmaceutical), ROSUVASTATIN CALCIUM (Solco Healthcare LLC), ROSUVASTATIN CALCIUM (Sun Pharmaceutical Industries), ROSUVASTATIN CALCIUM (Torrent Pharmaceuticals Limited), ROSUVASTATIN CALCIUM (Tris Pharma)
Formula
(C22H27FN3O6S)2. Ca
Exact mass
1000.2835
Mol weight
1001.1374
Structure
Class
Hypolipidemic agent
 DG01946  Hypolipidemic agent
  DG01660  HMG-CoA reductase inhibitor
Transporter substrate
 DG01913  ABCG2 substrate
 DG02856  SLCO1B1 substrate
Remark
Therapeutic category: 2189
ATC code: C10AA07
Chemical structure group: DG00357
Product (DG00357): D01915<JP/US>
Product (mixture): D11520<JP/US>
Efficacy
Antihyperlipidemic, HMG-CoA reductase inhibitor
  Disease
Hypertriglyceridemia [DS:H01637]
Primary dysbetalipoproteinemia; type III hyperlipoproteinemia [DS:H01637]
Homozygous familial hypercholesterolemia [DS:H00155]
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Metabolism
Transporter: SLCO1B1 [HSA:10599], ABCG2 [HSA:9429]
Interaction
Structure map
map07024  HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA07 Rosuvastatin
      D01915  Rosuvastatin calcium (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Rosuvastatin
    D01915  Rosuvastatin calcium (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D01915  Rosuvastatin calcium (JP18/USP)
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG01660  HMG-CoA reductase inhibitor
    DG00357  Rosuvastatin
     D01915  Rosuvastatin calcium
 Transporter substrate
  DG01913  ABCG2 substrate
   DG00357  Rosuvastatin
    D01915  Rosuvastatin calcium
  DG02856  SLCO1B1 substrate
   DG00357  Rosuvastatin
    D01915  Rosuvastatin calcium
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01946  Hypolipidemic agent
   D01915  Rosuvastatin calcium
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    HMGCR
     D01915  Rosuvastatin calcium (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01915  Rosuvastatin calcium
  D01915  Rosuvastatin calcium tablets
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01915
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01915
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01915
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D01915
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D01915
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG01660  HMG-CoA reductase inhibitor
    DG00357  Rosuvastatin
 Transporter substrate
  DG01913  ABCG2 substrate
   DG00357  Rosuvastatin
  DG02856  SLCO1B1 substrate
   DG00357  Rosuvastatin
Other DBs
CAS: 147098-20-2
PubChem: 7848977
ChEBI: 77249
LigandBox: D01915
KCF data

ATOM        67
            1   C8y C    24.4367  -20.6549
            2   N5x N    24.4367  -22.0555
            3   C8y C    25.6498  -22.7558
            4   N5x N    26.8627  -22.0555
            5   C8y C    26.8627  -20.6549
            6   C8y C    25.6498  -19.9546
            7   C1c C    28.0770  -19.9538
            8   C1a C    29.2913  -20.6549
            9   C1a C    28.0770  -18.5540
            10  C2b C    25.6498  -18.5540
            11  C2b C    26.8634  -17.8533
            12  C1c C    26.8634  -16.4531
            13  O1a O    28.0772  -15.7523
            14  C1b C    25.6513  -15.7533
            15  C1c C    25.6507  -14.3522
            16  O1a O    24.4373  -13.6524
            17  C1b C    26.8633  -13.6514
            18  C6a C    28.2651  -13.6519
            19  O6a O    28.9659  -12.4392
            20  O6a O    28.9649  -14.8651 #-
            21  N1c N    25.6498  -24.1565
            22  S4a S    26.8634  -24.8572
            23  C1a C    24.4374  -24.8564
            24  C1a C    28.0773  -24.1563
            25  O3c O    25.8841  -25.8373
            26  O3c O    27.8449  -25.8373
            27  C8y C    23.2238  -19.9546
            28  C8x C    23.2238  -18.5540
            29  C8x C    22.0108  -17.8537
            30  C8y C    20.7978  -18.5540
            31  C8x C    20.7978  -19.9546
            32  C8x C    22.0108  -20.6549
            33  X   F    19.5828  -17.8525
            34  Z   Ca   33.4941  -14.9124 #2+
            35  C8y C    24.4367  -20.6549
            36  N5x N    24.4367  -22.0555
            37  C8y C    25.6498  -22.7558
            38  N5x N    26.8627  -22.0555
            39  C8y C    26.8627  -20.6549
            40  C8y C    25.6498  -19.9546
            41  C2b C    25.6498  -18.5540
            42  C2b C    26.8634  -17.8533
            43  C1c C    26.8634  -16.4531
            44  O1a O    28.0772  -15.7523
            45  C1b C    25.6513  -15.7533
            46  C1c C    25.6507  -14.3522
            47  O1a O    24.4373  -13.6524
            48  C1b C    26.8633  -13.6514
            49  C6a C    28.2651  -13.6519
            50  O6a O    28.9659  -12.4392
            51  O6a O    28.9649  -14.8651 #-
            52  C1c C    28.0770  -19.9538
            53  C1a C    29.2913  -20.6549
            54  C1a C    28.0770  -18.5540
            55  N1c N    25.6498  -24.1565
            56  S4a S    26.8634  -24.8572
            57  C1a C    28.0773  -24.1563
            58  O3c O    25.8841  -25.8373
            59  O3c O    27.8449  -25.8373
            60  C1a C    24.4374  -24.8564
            61  C8y C    23.2238  -19.9546
            62  C8x C    23.2238  -18.5540
            63  C8x C    22.0108  -17.8537
            64  C8y C    20.7978  -18.5540
            65  C8x C    20.7978  -19.9546
            66  C8x C    22.0108  -20.6549
            67  X   F    19.5828  -17.8525
BOND        68
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     7   9 1
            10    6  10 1
            11   10  11 2
            12   12  11 1 #Down
            13   12  13 1
            14   12  14 1
            15   14  15 1
            16   15  16 1 #Up
            17   15  17 1
            18   17  18 1
            19   18  19 2
            20   18  20 1
            21    3  21 1
            22   21  22 1
            23   21  23 1
            24   22  24 1
            25   22  25 2
            26   22  26 2
            27    1  27 1
            28   27  28 2
            29   28  29 1
            30   29  30 2
            31   30  31 1
            32   31  32 2
            33   27  32 1
            34   30  33 1
            35   35  36 2
            36   36  37 1
            37   37  38 2
            38   38  39 1
            39   39  40 2
            40   35  40 1
            41   39  52 1
            42   52  53 1
            43   52  54 1
            44   40  41 1
            45   41  42 2
            46   43  42 1 #Down
            47   43  44 1
            48   43  45 1
            49   45  46 1
            50   46  47 1 #Up
            51   46  48 1
            52   48  49 1
            53   49  50 2
            54   49  51 1
            55   37  55 1
            56   55  56 1
            57   55  60 1
            58   56  57 1
            59   56  58 2
            60   56  59 2
            61   35  61 1
            62   61  62 2
            63   62  63 1
            64   63  64 2
            65   64  65 1
            66   65  66 2
            67   61  66 1
            68   64  67 1
BRACKET     1    18.4100  -26.5300   18.4100  -11.4100
            1    31.4300  -11.4100   31.4300  -26.5300
            1  2
 ORIGINAL  1    1   2   3   4   5   6  10  11  12  13  14  15  16  17  18  19
            1   20   7   8   9  21  22  24  25  26  23  27  28  29  30  31  32
            1   33
 REPEAT    1   35  36  37  38  39  40  41  42  43  44  45  46  47  48  49  50
            1   51  52  53  54  55  56  57  58  59  60  61  62  63  64  65  66
            1   67